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Kiz kizuna centrosomal protein [ Mus musculus (house mouse) ]

Gene ID: 228730, updated on 9-Dec-2024

Summary

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Official Symbol
Kizprovided by MGI
Official Full Name
kizuna centrosomal proteinprovided by MGI
Primary source
MGI:MGI:2684960
See related
Ensembl:ENSMUSG00000074749 AllianceGenome:MGI:2684960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm114; Plk1s1; Ncrna00153
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in spindle organization. Located in cytoplasm. Is expressed in central nervous system; gonad; sensory organ; and thyroid gland. Human ortholog(s) of this gene implicated in retinitis pigmentosa 69. Orthologous to human KIZ (kizuna centrosomal protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in testis adult (RPKM 20.8), bladder adult (RPKM 4.3) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Kiz in Genome Data Viewer
Location:
2 G2; 2 72.63 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (146697743..146812018)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (146855825..146970098)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 35433 Neighboring gene STARR-seq mESC enhancer starr_05952 Neighboring gene predicted gene 14114 Neighboring gene predicted gene, 34978 Neighboring gene STARR-positive B cell enhancer ABC_E11165 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene Mki67 (FHA domain) interacting nucleolar phosphoprotein pseudogene Neighboring gene STARR-seq mESC enhancer starr_05954 Neighboring gene STARR-seq mESC enhancer starr_05956 Neighboring gene STARR-seq mESC enhancer starr_05957 Neighboring gene 5'-3' exoribonuclease 2 Neighboring gene NK2 homeobox 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KIZ/GM114 Balances the NF-ĸB Signaling by Antagonizing the Association of TRAF2/6 With Their Upstream Adaptors. Sun J, et al. Front Cell Dev Biol, 2022. PMID 35433693, Free PMC Article
  2. Whole-exome sequencing identifies KIZ as a ciliary gene associated with autosomal-recessive rod-cone dystrophy. El Shamieh S, et al. Am J Hum Genet, 2014 Apr 3. PMID 24680887, Free PMC Article
  3. Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam. Tang H, et al. Dev Biol, 2008 Jun 1. PMID 18423593, Free PMC Article
  4. Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background. Cook MS, et al. Development, 2011 Jan. PMID 21115610, Free PMC Article
  5. The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency. Krentz AD, et al. Proc Natl Acad Sci U S A, 2009 Dec 29. PMID 20007774, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results describe the expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam.
    Title: Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle organization ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
centrosomal protein kizuna
Names
polo-like kinase 1 substrate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033298.4 → NP_001028470.1  centrosomal protein kizuna

    See identical proteins and their annotated locations for NP_001028470.1

    Status: VALIDATED

    Source sequence(s)
    AK135486, AL929215
    Consensus CDS
    CCDS16832.1
    UniProtKB/Swiss-Prot
    A2AUS7, B2RX19, Q3UXL4
    Related
    ENSMUSP00000096884.3, ENSMUST00000099278.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    146697743..146812018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161421.1 → XP_036017314.1  centrosomal protein kizuna isoform X1

  2. XM_036161424.1 → XP_036017317.1  centrosomal protein kizuna isoform X3

  3. XM_006499298.4 → XP_006499361.1  centrosomal protein kizuna isoform X2

  4. XM_030250542.2 → XP_030106402.1  centrosomal protein kizuna isoform X4

RNA

  1. XR_004940113.1 RNA Sequence

  2. XR_004940114.1 RNA Sequence

  3. XR_004940116.1 RNA Sequence

  4. XR_003952536.2 RNA Sequence

  5. XR_004940115.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UXL4.1 GenPept UniProtKB/Swiss-Prot:Q3UXL4

Gene LinkOut

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