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Nrsn2 neurensin 2 [ Mus musculus (house mouse) ]

Gene ID: 228777, updated on 30-Apr-2024

Summary

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Official Symbol
Nrsn2provided by MGI
Official Full Name
neurensin 2provided by MGI
Primary source
MGI:MGI:2684969
See related
Ensembl:ENSMUSG00000059361 AllianceGenome:MGI:2684969
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm123; Neurensin-2
Summary
Predicted to be involved in nervous system development. Located in neuronal cell body and transport vesicle. Is expressed in brain. Orthologous to human NRSN2 (neurensin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 18.9), frontal lobe adult (RPKM 14.9) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Nrsn2 in Genome Data Viewer
Location:
2 G3; 2 74.89 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152210675..152218560, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152368755..152376625, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11172 Neighboring gene tribbles pseudokinase 3 Neighboring gene STARR-seq mESC enhancer starr_06055 Neighboring gene predicted gene 14164 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06057 Neighboring gene VISTA enhancer mm271 Neighboring gene SRY (sex determining region Y)-box 12 Neighboring gene STARR-positive B cell enhancer mm9_chr2:152231818-152232119 Neighboring gene zinc finger, CCHC domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Activation of the p11/SMARCA3/Neurensin-2 pathway in parvalbumin interneurons mediates the response to chronic antidepressants. Umschweif G, et al. Mol Psychiatry, 2021 Jul. PMID 33723417, Free PMC Article
  2. Molecular characterization of a transport vesicle protein Neurensin-2, a homologue of Neurensin-1, expressed in neural cells. Nakanishi K, et al. Brain Res, 2006 Apr 7. PMID 16527258
  3. Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development. Tiklová K, et al. Nat Commun, 2019 Feb 4. PMID 30718509, Free PMC Article
  4. The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex. Schilling K, et al. Cerebellum, 2009 Dec. PMID 19554387
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activation of the p11/SMARCA3/Neurensin-2 pathway in parvalbumin interneurons mediates the response to chronic antidepressants.
    Title: Activation of the p11/SMARCA3/Neurensin-2 pathway in parvalbumin interneurons mediates the response to chronic antidepressants.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Clone Names

  • MGC113772

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in transport vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neurensin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009948.2 → NP_001009948.1  neurensin-2 isoform 1

    See identical proteins and their annotated locations for NP_001009948.1

    Status: VALIDATED

    Source sequence(s)
    AL928568
    Consensus CDS
    CCDS16882.1
    UniProtKB/Swiss-Prot
    A2AS81, Q3USR0, Q5HZK2
    Related
    ENSMUSP00000078260.5, ENSMUST00000079278.5
    Conserved Domains (1) summary
    pfam14927
    Location:21 → 154
    Neurensin; Neurensin

  2. NM_001370749.1 → NP_001357678.1  neurensin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL928568
    Conserved Domains (1) summary
    pfam14927
    Location:2 → 93
    Neurensin

  3. NM_001370750.1 → NP_001357679.1  neurensin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL928568
    Conserved Domains (1) summary
    pfam14927
    Location:21 → 116
    Neurensin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152210675..152218560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499311.2 → XP_006499374.1  neurensin-2 isoform X1

    See identical proteins and their annotated locations for XP_006499374.1

    Conserved Domains (1) summary
    pfam14927
    Location:69 → 203
    Neurensin

  2. XM_006499312.5 → XP_006499375.1  neurensin-2 isoform X1

    See identical proteins and their annotated locations for XP_006499375.1

    Conserved Domains (1) summary
    pfam14927
    Location:69 → 203
    Neurensin

  3. XM_030250574.1 → XP_030106434.1  neurensin-2 isoform X2

    Conserved Domains (1) summary
    pfam14927
    Location:2 → 93
    Neurensin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HZK2.1 GenPept UniProtKB/Swiss-Prot:Q5HZK2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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