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CD93 CD93 molecule [ Homo sapiens (human) ]

Gene ID: 22918, updated on 12-Nov-2024

Summary

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Official Symbol
CD93provided by HGNC
Official Full Name
CD93 moleculeprovided by HGNC
Primary source
HGNC:HGNC:15855
See related
Ensembl:ENSG00000125810 MIM:120577; AllianceGenome:HGNC:15855
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1QR1; C1qRP; CDw93; ECSM3; MXRA4; C1qR(P); dJ737E23.1
Summary
The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 64.0), lung (RPKM 47.5) and 21 other tissues See more
Orthologs
mouse all
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Genomic context

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See CD93 in Genome Data Viewer
Location:
20p11.21
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (23079360..23086324, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (23120610..23145801, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (23059997..23066961, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene thrombomodulin Neighboring gene Sharpr-MPRA regulatory region 8459 Neighboring gene uncharacterized LOC124904964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17629 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:23097446-23097628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17630 Neighboring gene long intergenic non-protein coding RNA 656 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:23117070-23118269 Neighboring gene Sharpr-MPRA regulatory region 14145 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:23128189-23129388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:23130883-23131866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12722 Neighboring gene long intergenic non-protein coding RNA 3125 Neighboring gene RNA, 5S ribosomal pseudogene 478

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Whole Transcriptome Profiling Identifies CD93 and Other Plasma Cell Survival Factor Genes Associated with Measles-Specific Antibody Response after Vaccination. Haralambieva IH, et al. PLoS One, 2016. PMID 27529750, Free PMC Article
  2. C1qRp defines a new human stem cell population with hematopoietic and hepatic potential. Danet GH, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12140365, Free PMC Article
  3. Cell surface expression of C1qRP/CD93 is stabilized by O-glycosylation. Park M, et al. J Cell Physiol, 2003 Sep. PMID 12891708
  4. Decrease in CD93 (C1qRp) expression in a human monocyte-like cell line (U937) treated with various apoptosis-inducing chemical substances. Ikewaki N, et al. Microbiol Immunol, 2007. PMID 18094537
  5. A hantavirus causing hemorrhagic fever with renal syndrome requires gC1qR/p32 for efficient cell binding and infection. Choi Y, et al. Virology, 2008 Nov 25. PMID 18834607

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Relationship of cerebrospinal fluid and serum levels of SIL-2R, eNOS, and CD93 with the progression and prognosis of viral encephalitis in children].
    Title: [Relationship of cerebrospinal fluid and serum levels of SIL-2R, eNOS, and CD93 with the progression and prognosis of viral encephalitis in children].
  2. Clinicopathological association of CD93 expression in gastric adenocarcinoma.
    Title: Clinicopathological association of CD93 expression in gastric adenocarcinoma.
  3. CD93 regulates breast cancer growth and vasculogenic mimicry through the PI3K/AKT/SP2 signaling pathway activated by integrin beta1.
    Title: CD93 regulates breast cancer growth and vasculogenic mimicry through the PI3K/AKT/SP2 signaling pathway activated by integrin β1.
  4. Structural insight into CD93 recognition by IGFBP7.
    Title: Structural insight into CD93 recognition by IGFBP7.
  5. Blockade of CD93 in pleural mesothelial cells fuels anti-lung tumor immune responses.
    Title: Blockade of CD93 in pleural mesothelial cells fuels anti-lung tumor immune responses.
  6. The analysis of multiple omics and examination of pathological images revealed the prognostic and therapeutic significances of CD93 in lung squamous cell carcinoma.
    Title: The analysis of multiple omics and examination of pathological images revealed the prognostic and therapeutic significances of CD93 in lung squamous cell carcinoma.
  7. First Trimester CD93 as a Novel Marker of Preeclampsia and Its Complications: A Pilot Study.
    Title: First Trimester CD93 as a Novel Marker of Preeclampsia and Its Complications: A Pilot Study.
  8. CD93 Ameliorates Diabetic Wounds by Promoting Angiogenesis via the p38MAPK/MK2/HSP27 Axis.
    Title: CD93 Ameliorates Diabetic Wounds by Promoting Angiogenesis via the p38MAPK/MK2/HSP27 Axis.
  9. Diagnostic and Prognostic Role of CD93 in Cardiovascular Disease: A Systematic Review.
    Title: Diagnostic and Prognostic Role of CD93 in Cardiovascular Disease: A Systematic Review.
  10. Multi-omics profiling and digital image analysis reveal the potential prognostic and immunotherapeutic properties of CD93 in stomach adenocarcinoma.
    Title: Multi-omics profiling and digital image analysis reveal the potential prognostic and immunotherapeutic properties of CD93 in stomach adenocarcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (53)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of liver enzymes in korean children.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables complement component C1q complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in macrophage activation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in phagocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in secretory granule membrane TAS
Traceable Author Statement
more info
  
located_in specific granule membrane TAS
Traceable Author Statement
more info
  
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
complement component C1q receptor
Names
C1q receptor 1
C1q/MBL/SPA receptor
C1qR
CD93 antigen
complement component 1 q subcomponent receptor 1
matrix-remodeling-associated protein 4
matrix-remodelling associated 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012072.4 → NP_036204.2  complement component C1q receptor precursor

    See identical proteins and their annotated locations for NP_036204.2

    Status: REVIEWED

    Source sequence(s)
    AL118508, BC028075, U94333
    Consensus CDS
    CCDS13149.1
    UniProtKB/Swiss-Prot
    O00274, Q9NPY3
    UniProtKB/TrEMBL
    Q8IXK1
    Related
    ENSP00000246006.4, ENST00000246006.5
    Conserved Domains (6) summary
    cd03600
    Location:31 → 184
    CLECT_thrombomodulin_like; C-type lectin-like domain (CTLD) of the type found in human thrombomodulin(TM), Endosialin, C14orf27, and C1qR
    smart00179
    Location:427 → 468
    EGF_CA; Calcium-binding EGF-like domain
    pfam07645
    Location:385 → 425
    EGF_CA; Calcium-binding EGF domain
    pfam09422
    Location:464 → 549
    WTX; WTX protein
    pfam12662
    Location:326 → 348
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:264 → 300
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    23079360..23086324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    23120610..23145801 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008485242.1 RNA Sequence

  2. XR_008485243.1 RNA Sequence

  3. XR_008485244.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NPY3.3 GenPept UniProtKB/Swiss-Prot:Q9NPY3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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