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PLA2R1 phospholipase A2 receptor 1 [ Homo sapiens (human) ]

Gene ID: 22925, updated on 2-Nov-2024

Summary

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Official Symbol
PLA2R1provided by HGNC
Official Full Name
phospholipase A2 receptor 1provided by HGNC
Primary source
HGNC:HGNC:9042
See related
Ensembl:ENSG00000153246 MIM:604939; AllianceGenome:HGNC:9042
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLA2R; PLA2-R; PLA2IR; CLEC13C; PLA2G1R
Summary
This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Expression
Broad expression in thyroid (RPKM 11.6), kidney (RPKM 5.9) and 16 other tissues See more
Orthologs
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Genomic context

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See PLA2R1 in Genome Data Viewer
Location:
2q24.2
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (159923933..160062615, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (160390236..160520476, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (160788517..160919126, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene LY75-CD302 readthrough Neighboring gene uncharacterized LOC124906083 Neighboring gene CD302 molecule Neighboring gene lymphocyte antigen 75 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16695 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:160761228-160761469 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16696 Neighboring gene uncharacterized LOC105373717 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:160911725-160912406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16697 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:160982362-160982960 Neighboring gene integrin subunit beta 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:161037195-161037767 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:161037768-161038339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16701 Neighboring gene ITGB6-RBMS1 intergenic CAGE-defined low expression enhancer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53984 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:161126614-161127223 Neighboring gene long intergenic non-protein coding RNA 2478

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Phospholipase A(2) Receptor Gene Polymorphisms Alter its Functions and Present a Genetic Risk of an Increased Intima-Media Thickness of the Carotid Artery. Si NV, et al. J Atheroscler Thromb, 2016 Oct 1. PMID 27025682, Free PMC Article
  2. Phospholipase A2 receptor (PLA2R1) sequence variants in idiopathic membranous nephropathy. Coenen MJ, et al. J Am Soc Nephrol, 2013 Mar. PMID 23431073, Free PMC Article
  3. Clinical and Histological Features of Phospholipase A2 Receptor-Associated and Thrombospondin Type-I Domain-containing 7A-Associated Idiopathic Membranous Nephropathy: A Single Center Retrospective Study from China. Zhang D, et al. Med Sci Monit, 2018 Jul 22. PMID 30032157, Free PMC Article
  4. Human soluble phospholipase A(2) receptor is an inhibitor of the integrin-mediated cell migratory response to collagen-I. Watanabe K, et al. Am J Physiol Cell Physiol, 2018 Sep 1. PMID 29791208
  5. Phospholipase A2 receptor staining in pediatric idiopathic membranous glomerulopathy. Cossey LN, et al. Pediatr Nephrol, 2013 Dec. PMID 23903693

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phospholipid metabolism-related genotypes of PLA2R1 and CERS4 contribute to nonobese MASLD.
    Title: Phospholipid metabolism-related genotypes of PLA2R1 and CERS4 contribute to nonobese MASLD.
  2. Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17.
    Title: Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17.
  3. Organelle resolved proteomics uncovers PLA2R1 as a novel cell surface marker required for chordoma growth.
    Title: Organelle resolved proteomics uncovers PLA2R1 as a novel cell surface marker required for chordoma growth.
  4. The Role of PLA2R in Primary Membranous Nephropathy: Do We Still Need a Kidney Biopsy?
    Title: The Role of PLA2R in Primary Membranous Nephropathy: Do We Still Need a Kidney Biopsy?
  5. [Mechanism of podocyte pyroptosis aggravated by up-regulation of phospholipase A2 receptor by hepatitis B virus X protein].
    Title: [Mechanism of podocyte pyroptosis aggravated by up-regulation of phospholipase A(2) receptor by hepatitis B virus X protein].
  6. Comprehensively characterizing cellular changes and the expression of THSD7A and PLA2R1 under multiple in vitro models of podocyte injury.
    Title: Comprehensively characterizing cellular changes and the expression of THSD7A and PLA2R1 under multiple in vitro models of podocyte injury.
  7. Association of serum mannose-binding lectin, anti-phospholipase A2 receptor antibody and renal outcomes in idiopathic membranous nephropathy and atypical membranous nephropathy: a single center retrospective cohort study.
    Title: Association of serum mannose-binding lectin, anti-phospholipase A2 receptor antibody and renal outcomes in idiopathic membranous nephropathy and atypical membranous nephropathy: a single center retrospective cohort study.
  8. Associations between m-type phospholipase A2 receptor,human leukocyte antigen gene polymorphisms and idiopathic membranous nephropathy.
    Title: Associations between m-type phospholipase A2 receptor,human leukocyte antigen gene polymorphisms and idiopathic membranous nephropathy.
  9. Seropositive PLA2R-associated membranous nephropathy but biopsy-negative PLA2R staining.
    Title: Seropositive PLA2R-associated membranous nephropathy but biopsy-negative PLA2R staining.
  10. Single-Cell Profiling Reveals Transcriptional Signatures and Cell-Cell Crosstalk in Anti-PLA2R Positive Idiopathic Membranous Nephropathy Patients.
    Title: Single-Cell Profiling Reveals Transcriptional Signatures and Cell-Cell Crosstalk in Anti-PLA2R Positive Idiopathic Membranous Nephropathy Patients.
Submit: New GeneRIF Correction See all GeneRIFs (91)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association of serum bilirubin levels in Korean population.
EBI GWAS Catalog
Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of arachidonate secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of phospholipase A2 activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in oxidative stress-induced premature senescence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of arachidonate secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of podocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in replicative senescence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
secretory phospholipase A2 receptor
Names
180 kDa secretory phospholipase A2 receptor
C-type lectin domain family 13 member C
M-type receptor
phospholipase A2 receptor 1, 180kD
phospholipase A2 receptor 1, 180kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007267.3 → NP_001007268.1  secretory phospholipase A2 receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001007268.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein. It encodes a secreted isoform (2), which lacks a C-terminal transmembrane region found in isoform 1.
    Source sequence(s)
    AC080166, AC093873, AI672072, AL598405, BC140823, BP351340, W15508
    Consensus CDS
    CCDS42767.1
    UniProtKB/Swiss-Prot
    Q13018
    Related
    ENSP00000376524.1, ENST00000392771.1
    Conserved Domains (5) summary
    smart00059
    Location:171 → 219
    FN2; Fibronectin type 2 domain
    cd00037
    Location:242 → 356
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:378 → 502
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:43 → 151
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:39 → 119
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

  2. NM_001195641.2 → NP_001182570.1  secretory phospholipase A2 receptor isoform 3 precursor

    See identical proteins and their annotated locations for NP_001182570.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC080166, AC093873, BC144631, BP351340, U17033
    UniProtKB/TrEMBL
    B7ZML4
    Conserved Domains (5) summary
    smart00059
    Location:171 → 219
    FN2; Fibronectin type 2 domain
    cd00037
    Location:242 → 356
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:378 → 502
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:43 → 151
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:39 → 119
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

  3. NM_007366.5 → NP_031392.3  secretory phospholipase A2 receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_031392.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC080166, AC093873, BC140823, BP351340, U17033
    Consensus CDS
    CCDS33309.1
    UniProtKB/Swiss-Prot
    B2RTU9, D3DPB1, Q13018, Q13019, Q15095, Q53R45, Q53RR7
    Related
    ENSP00000283243.7, ENST00000283243.13
    Conserved Domains (5) summary
    smart00059
    Location:171 → 219
    FN2; Fibronectin type 2 domain
    cd00037
    Location:242 → 356
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:378 → 502
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:43 → 151
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:39 → 119
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    159923933..160062615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443729.1 → XP_047299685.1  secretory phospholipase A2 receptor isoform X1

    UniProtKB/Swiss-Prot
    B2RTU9, D3DPB1, Q13018, Q13019, Q15095, Q53R45, Q53RR7

  2. XM_047443730.1 → XP_047299686.1  secretory phospholipase A2 receptor isoform X2

    UniProtKB/TrEMBL
    B7ZML4

  3. XM_011510820.4 → XP_011509122.1  secretory phospholipase A2 receptor isoform X1

    See identical proteins and their annotated locations for XP_011509122.1

    UniProtKB/Swiss-Prot
    B2RTU9, D3DPB1, Q13018, Q13019, Q15095, Q53R45, Q53RR7
    Conserved Domains (5) summary
    smart00059
    Location:171 → 219
    FN2; Fibronectin type 2 domain
    cd00037
    Location:242 → 356
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:378 → 502
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:43 → 151
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:39 → 119
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

  4. XM_005246392.5 → XP_005246449.1  secretory phospholipase A2 receptor isoform X1

    See identical proteins and their annotated locations for XP_005246449.1

    UniProtKB/Swiss-Prot
    B2RTU9, D3DPB1, Q13018, Q13019, Q15095, Q53R45, Q53RR7
    Conserved Domains (5) summary
    smart00059
    Location:171 → 219
    FN2; Fibronectin type 2 domain
    cd00037
    Location:242 → 356
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:378 → 502
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:43 → 151
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:39 → 119
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

  5. XM_017003598.2 → XP_016859087.1  secretory phospholipase A2 receptor isoform X1

    UniProtKB/Swiss-Prot
    B2RTU9, D3DPB1, Q13018, Q13019, Q15095, Q53R45, Q53RR7
    Conserved Domains (5) summary
    smart00059
    Location:171 → 219
    FN2; Fibronectin type 2 domain
    cd00037
    Location:242 → 356
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:378 → 502
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:43 → 151
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:39 → 119
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

  6. XM_017003599.2 → XP_016859088.1  secretory phospholipase A2 receptor isoform X3

  7. XM_047443731.1 → XP_047299687.1  secretory phospholipase A2 receptor isoform X4

  8. XM_017003601.3 → XP_016859090.1  secretory phospholipase A2 receptor isoform X5

RNA

  1. XR_922892.4 RNA Sequence

  2. XR_007071491.1 RNA Sequence

  3. XR_001738672.3 RNA Sequence

  4. XR_001738671.3 RNA Sequence

  5. XR_007071492.1 RNA Sequence

  6. XR_007071494.1 RNA Sequence

  7. XR_007071493.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    160390236..160520476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341041.1 → XP_054197016.1  secretory phospholipase A2 receptor isoform X3

  2. XM_054341042.1 → XP_054197017.1  secretory phospholipase A2 receptor isoform X4

  3. XM_054341043.1 → XP_054197018.1  secretory phospholipase A2 receptor isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13018.2 GenPept UniProtKB/Swiss-Prot:Q13018

Gene LinkOut

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