Gpr171 G protein-coupled receptor 171 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr171provided by MGI
Official Full Name: G protein-coupled receptor 171provided by MGI
Primary source: MGI:MGI:2442043
See related: Ensembl:ENSMUSG00000050075 AllianceGenome:MGI:2442043
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H963; A630006E05; F730001G15Rik
Summary: Enables neuropeptide binding activity and neuropeptide receptor activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway; regulation of feeding behavior; and regulation of sensory perception of pain. Acts upstream of or within negative regulation of myeloid cell differentiation. Located in plasma membrane. Orthologous to human GPR171 (G protein-coupled receptor 171). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in thymus adult (RPKM 4.5), spleen adult (RPKM 2.7) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 D; 3 28.94 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (59003869..59009242, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (59096448..59101821, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A small molecule ligand for the novel pain target, GPR171, produces minimal reward in mice.
Title: A small molecule ligand for the novel pain target, GPR171, produces minimal reward in mice.
GPR171 activation regulates morphine tolerance but not withdrawal in a test-dependent manner in mice.
Title: GPR171 activation regulates morphine tolerance but not withdrawal in a test-dependent manner in mice.
The GPR171 pathway suppresses T cell activation and limits antitumor immunity.
Title: The GPR171 pathway suppresses T cell activation and limits antitumor immunity.
GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding.
Title: GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding.
findings indicate that the orphan receptor Gpr171 negatively regulates myeloid differentiation
Title: Gpr171, a putative P2Y-like receptor, negatively regulates myeloid differentiation in murine hematopoietic progenitors.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled purinergic nucleotide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide binding	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of myeloid cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G-protein coupled receptor 171

Names: probable G-protein coupled receptor 171

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.