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Elapor1 endosome-lysosome associated apoptosis and autophagy regulator 1 [ Mus musculus (house mouse) ]

Gene ID: 229722, updated on 9-Dec-2024

Summary

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Official Symbol
Elapor1provided by MGI
Official Full Name
endosome-lysosome associated apoptosis and autophagy regulator 1provided by MGI
Primary source
MGI:MGI:1923930
See related
Ensembl:ENSMUSG00000040412 AllianceGenome:MGI:1923930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Iir; Inceptor; 5330417C22Rik
Summary
Predicted to be involved in autophagosome assembly; cellular response to starvation; and positive regulation of autophagosome assembly. Predicted to be located in Golgi apparatus; bounding membrane of organelle; and endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Predicted to colocalize with late endosome; lysosome; and trans-Golgi network. Orthologous to human ELAPOR1 (endosome-lysosome associated apoptosis and autophagy regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in testis adult (RPKM 38.0), colon adult (RPKM 28.0) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Elapor1 in Genome Data Viewer
Location:
3 F3; 3 47.14 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108362995..108444064, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108455679..108536745, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 2 Neighboring gene predicted gene, 52630 Neighboring gene STARR-seq mESC enhancer starr_08687 Neighboring gene seryl-tRNA synthetase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:108248013-108248314 Neighboring gene STARR-seq mESC enhancer starr_08688 Neighboring gene predicted gene, 22942 Neighboring gene predicted gene, 23336 Neighboring gene STARR-seq mESC enhancer starr_08689 Neighboring gene STARR-positive B cell enhancer ABC_E4574 Neighboring gene cilia and flagella associated protein 276 Neighboring gene small Cajal body-specific RNA 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis. Cho CJ, et al. Am J Physiol Gastrointest Liver Physiol, 2022 Jan 1. PMID 34816763, Free PMC Article
  2. Inceptor facilitates acrosomal vesicle formation in spermatids and is required for male fertility. Bilekova S, et al. Front Cell Dev Biol, 2023. PMID 37691832, Free PMC Article
  3. A single transcription factor is sufficient to induce and maintain secretory cell architecture. Lo HG, et al. Genes Dev, 2017 Jan 15. PMID 28174210, Free PMC Article
  4. RREB1 regulates neuronal proteostasis and the microtubule network. Griffin EN, et al. Sci Adv, 2024 Jan 12. PMID 38198538, Free PMC Article
  5. Inceptor counteracts insulin signalling in β-cells to control glycaemia. Ansarullah, et al. Nature, 2021 Feb. PMID 33505018

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis.
    Title: ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (5)  1 citation

General gene information

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Markers

Homology

Clone Names

  • KIAA1324

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vacuole organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of vacuole organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with lysosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endosome/lysosome-associated apoptosis and autophagy regulator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033304.2 → NP_001028476.1  endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 2

    See identical proteins and their annotated locations for NP_001028476.1

    Status: VALIDATED

    Source sequence(s)
    AK139330, AL672200, AL683823, BP763374
    Consensus CDS
    CCDS17761.1
    UniProtKB/Swiss-Prot
    A2AFS2, A2AFS3, Q3UTM2, Q69ZL9, Q7TS96, Q8R215
    Related
    ENSMUSP00000040128.7, ENSMUST00000048012.13
    Conserved Domains (2) summary
    pfam07562
    Location:279 → 315
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl22855
    Location:163 → 295
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  2. NM_001346518.1 → NP_001333447.1  endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL672200, AL683823, BP763374
    Consensus CDS
    CCDS84664.1
    UniProtKB/Swiss-Prot
    A2AFS2, A2AFS3, Q3UTM2, Q69ZL9, Q7TS96, Q8R215
    UniProtKB/TrEMBL
    A0A0A0MQC6
    Related
    ENSMUSP00000102236.4, ENSMUST00000106625.10

  3. NM_001358063.1 → NP_001344992.1  endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL672200, AL683823, BP763374
    UniProtKB/Swiss-Prot
    A2AFS2, A2AFS3, Q3UTM2, Q69ZL9, Q7TS96, Q8R215
    Conserved Domains (1) summary
    cl22855
    Location:265 → 397
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  4. NM_001358064.1 → NP_001344993.1  endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AL672200, AL683823, BP763374
    UniProtKB/Swiss-Prot
    A2AFS2, A2AFS3, Q3UTM2, Q69ZL9, Q7TS96, Q8R215
    Conserved Domains (1) summary
    cl22855
    Location:265 → 397
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  5. NM_001358065.1 → NP_001344994.1  endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL672200, AL683823, BP763374
    UniProtKB/Swiss-Prot
    A2AFS2, A2AFS3, Q3UTM2, Q69ZL9, Q7TS96, Q8R215
    Conserved Domains (1) summary
    cl22855
    Location:163 → 295
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    108362995..108444064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252595.2 → XP_030108455.1  endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform X2

    UniProtKB/Swiss-Prot
    A2AFS2, A2AFS3, Q3UTM2, Q69ZL9, Q7TS96, Q8R215
    Conserved Domains (3) summary
    cd00185
    Location:193 → 228
    TNFRSF; CRD2 [structural motif]
    pfam07562
    Location:279 → 315
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl22855
    Location:163 → 295
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  2. XM_006501415.4 → XP_006501478.1  endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform X1

    See identical proteins and their annotated locations for XP_006501478.1

    UniProtKB/Swiss-Prot
    A2AFS2, A2AFS3, Q3UTM2, Q69ZL9, Q7TS96, Q8R215
    Conserved Domains (2) summary
    pfam07562
    Location:279 → 315
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl22855
    Location:163 → 295
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  3. XM_006501414.5 → XP_006501477.1  endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform X1

    See identical proteins and their annotated locations for XP_006501477.1

    UniProtKB/Swiss-Prot
    A2AFS2, A2AFS3, Q3UTM2, Q69ZL9, Q7TS96, Q8R215
    Conserved Domains (2) summary
    pfam07562
    Location:279 → 315
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl22855
    Location:163 → 295
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RNA

  1. XR_004941314.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AFS3.1 GenPept UniProtKB/Swiss-Prot:A2AFS3

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