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NT5C2 5'-nucleotidase, cytosolic II [ Homo sapiens (human) ]

Gene ID: 22978, updated on 10-Dec-2024

Summary

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Official Symbol
NT5C2provided by HGNC
Official Full Name
5'-nucleotidase, cytosolic IIprovided by HGNC
Primary source
HGNC:HGNC:8022
See related
Ensembl:ENSG00000076685 MIM:600417; AllianceGenome:HGNC:8022
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GMP; NT5B; PNT5; SPG45; SPG65; cN-II
Summary
This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in thyroid (RPKM 20.3), esophagus (RPKM 12.5) and 25 other tissues See more
Orthologs
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Genomic context

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See NT5C2 in Genome Data Viewer
Location:
10q24.32-q24.33
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (103088017..103193272, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (103974258..104079521, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (104847774..104953029, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BORCS7-ASMT readthrough (NMD candidate) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104657816-104658316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104658317-104658817 Neighboring gene uncharacterized LOC107984265 Neighboring gene arsenite methyltransferase Neighboring gene ribosomal protein L22 pseudogene 17 Neighboring gene Sharpr-MPRA regulatory region 3077 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:104677004-104677690 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:104677691-104678377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2775 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 2 Neighboring gene MPRA-validated peak1082 silencer Neighboring gene Sharpr-MPRA regulatory region 2614 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3953 Neighboring gene ribosomal protein S15a pseudogene 29 Neighboring gene MARCKS like 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104946667-104947166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104946165-104946666 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:104951770-104952458 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:104952459-104953145 Neighboring gene CRISPRi-validated cis-regulatory element chr10.3946 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:104962099-104962305 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:104964236-104964895 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:104964896-104965554 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:104990595-104991592 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:104991593-104992590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2777 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3955 Neighboring gene ST13, Hsp70 interacting protein pseudogene 13 Neighboring gene ribulose-5-phosphate-3-epimerase like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. NT5C2 novel splicing variant expands the phenotypic spectrum of Spastic Paraplegia (SPG45): case report of a new member of thin corpus callosum SPG-Subgroup. Elsaid MF, et al. BMC Med Genet, 2017 Mar 21. PMID 28327087, Free PMC Article
  2. Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia. Jiang C, et al. Clin Pharmacol Ther, 2021 Jun. PMID 33124053, Free PMC Article
  3. Association between NT5C2 rs11191580 and autism spectrum disorder in the Chinese Han population. Xie X, et al. Asian J Psychiatr, 2020 Oct. PMID 32590138
  4. NT5C2 Gene Polymorphisms and the Risk of Coronary Heart Disease. Chen X, et al. Public Health Genomics, 2020. PMID 32541135
  5. Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia. Barz MJ, et al. Blood, 2020 Mar 19. PMID 31971569, Free PMC Article

See all (120) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neurons.
    Title: Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neurons.
  2. Silencing of circ-NT5C2 retards the progression of IL-1beta-induced osteoarthritis in an in vitro cell model by targeting the miR-142-5p/NAMPT axis.
    Title: Silencing of circ-NT5C2 retards the progression of IL-1β-induced osteoarthritis in an in vitro cell model by targeting the miR-142-5p/NAMPT axis.
  3. Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants.
    Title: Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants.
  4. NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells.
    Title: NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells.
  5. Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation.
    Title: Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation.
  6. Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia.
    Title: Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia.
  7. Cytosolic 5'-Nucleotidase II Silencing in Lung Tumor Cells Regulates Metabolism through Activation of the p53/AMPK Signaling Pathway.
    Title: Cytosolic 5'-Nucleotidase II Silencing in Lung Tumor Cells Regulates Metabolism through Activation of the p53/AMPK Signaling Pathway.
  8. Association between NT5C2 rs11191580 and autism spectrum disorder in the Chinese Han population.
    Title: Association between NT5C2 rs11191580 and autism spectrum disorder in the Chinese Han population.
  9. CD73 and cN-II regulate the cellular response to chemotherapeutic and hypoxic stress in lung adenocarcinoma cells.
    Title: CD73 and cN-II regulate the cellular response to chemotherapeutic and hypoxic stress in lung adenocarcinoma cells.
  10. NT5C2 Gene Polymorphisms and the Risk of Coronary Heart Disease.
    Title: NT5C2 Gene Polymorphisms and the Risk of Coronary Heart Disease.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Hereditary spastic paraplegia 45
MedGen: C3888209 OMIM: 613162 GeneReviews: Not available
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EBI GWAS Catalog

Description
A comprehensive family-based replication study of schizophrenia genes.
EBI GWAS Catalog
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
EBI GWAS Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
EBI GWAS Catalog
Genome-wide association study identifies eight loci associated with blood pressure.
EBI GWAS Catalog
Genome-wide association study identifies five new schizophrenia loci.
EBI GWAS Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
EBI GWAS Catalog
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
EBI GWAS Catalog
Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci.
EBI GWAS Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
EBI GWAS Catalog
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of 5'-nucleotidase, cytosolic II (NT5C2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-nucleotidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GMP 5'-nucleotidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables IMP 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables XMP 5'-nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside phosphotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in GMP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in IMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in IMP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in IMP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in allantoin metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dGMP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of defense response to virus by host IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
cytosolic purine 5'-nucleotidase
Names
5'-nucleotidase (purine), cytosolic type B
IMP-specific 5'-NT
cytosolic IMP/GMP-specific 5'-nucleotidase
cytosolic nucleoside phosphotransferase 5'N
epididymis secretory sperm binding protein
high Km 5'-nucleotidase
spastic paraplegia 45 (autosomal recessive)
NP_001127845.1
NP_001338098.1
NP_001338099.1
NP_001338100.1
NP_001338101.1
NP_001338102.1
NP_001338103.1
NP_001338104.1
NP_001338105.1
NP_001338106.1
NP_001338107.1
NP_001338108.1
NP_001338109.1
NP_001338110.1
NP_001338111.1
NP_001338112.1
NP_001338113.1
NP_001338114.1
NP_001338115.1
NP_001338116.1
NP_001338117.1
NP_001338118.1
NP_001338119.1
NP_001338120.1
NP_001338121.1
NP_001338122.1
NP_001338123.1
NP_001338124.1
NP_001338125.1
NP_001338126.1
NP_036361.1
XP_005269694.1
XP_011537839.1
XP_016871436.1
XP_024303669.1
XP_024303670.1
XP_024303671.1
XP_047280800.1
XP_047280801.1
XP_047280802.1
XP_047280803.1
XP_047280804.1
XP_047280805.1
XP_047280806.1
XP_047280807.1
XP_047280808.1
XP_047280809.1
XP_047280810.1
XP_047280811.1
XP_047280812.1
XP_047280813.1
XP_047280814.1
XP_047280815.1
XP_054221213.1
XP_054221214.1
XP_054221215.1
XP_054221216.1
XP_054221217.1
XP_054221218.1
XP_054221219.1
XP_054221220.1
XP_054221221.1
XP_054221222.1
XP_054221223.1
XP_054221224.1
XP_054221225.1
XP_054221226.1
XP_054221227.1
XP_054221228.1
XP_054221229.1
XP_054221230.1
XP_054221231.1
XP_054221232.1
XP_054221233.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042272.1 RefSeqGene

    Range
    5001..110290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001134373.3 → NP_001127845.1  cytosolic purine 5'-nucleotidase isoform 1

    See identical proteins and their annotated locations for NP_001127845.1

    Status: REVIEWED

    Source sequence(s)
    AL139817, AL360001
    Consensus CDS
    CCDS7544.1
    UniProtKB/Swiss-Prot
    B7Z382, D3DR91, P49902, Q5JUV5
    UniProtKB/TrEMBL
    A0A384MED8, A8K6K2
    Related
    ENSP00000339479.5, ENST00000343289.9
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 488
    5_nucleotid; 5' nucleotidase family

  2. NM_001351169.2 → NP_001338098.1  cytosolic purine 5'-nucleotidase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL139817, AL360001
    Consensus CDS
    CCDS7544.1
    UniProtKB/Swiss-Prot
    B7Z382, D3DR91, P49902, Q5JUV5
    UniProtKB/TrEMBL
    A0A384MED8, A8K6K2
    Related
    ENSP00000383960.3, ENST00000404739.8
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 488
    5_nucleotid; 5' nucleotidase family

  3. NM_001351170.2 → NP_001338099.1  cytosolic purine 5'-nucleotidase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BU618027, DB077941, DB169780
    Consensus CDS
    CCDS91340.1
    UniProtKB/TrEMBL
    A0A6Q8PHP0, A8K6K2
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 496
    5_nucleotid; 5' nucleotidase family

  4. NM_001351171.2 → NP_001338100.1  cytosolic purine 5'-nucleotidase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BP241199, BU618027, DB077941
    Consensus CDS
    CCDS91340.1
    UniProtKB/TrEMBL
    A0A6Q8PHP0, A8K6K2
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 496
    5_nucleotid; 5' nucleotidase family

  5. NM_001351172.2 → NP_001338101.1  cytosolic purine 5'-nucleotidase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BU618027, DB077941, DB164777
    Consensus CDS
    CCDS91340.1
    UniProtKB/TrEMBL
    A0A6Q8PHP0, A8K6K2
    Related
    ENSP00000502816.1, ENST00000674860.1
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 496
    5_nucleotid; 5' nucleotidase family

  6. NM_001351173.2 → NP_001338102.1  cytosolic purine 5'-nucleotidase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BU618027, BU622015, DB077941, DB164777
    Consensus CDS
    CCDS91340.1
    UniProtKB/TrEMBL
    A0A6Q8PHP0, A8K6K2
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 496
    5_nucleotid; 5' nucleotidase family

  7. NM_001351174.1 → NP_001338103.1  cytosolic purine 5'-nucleotidase isoform 3

    Status: REVIEWED

    Source sequence(s)
    AK295593, BC001595, BU618027, DC348363
    Consensus CDS
    CCDS91339.1
    UniProtKB/TrEMBL
    A8K6K2
    Related
    ENSP00000502215.1, ENST00000675985.1
    Conserved Domains (1) summary
    pfam05761
    Location:14 → 459
    5_nucleotid; 5' nucleotidase family

  8. NM_001351175.2 → NP_001338104.1  cytosolic purine 5'-nucleotidase isoform 4

    Status: REVIEWED

    Source sequence(s)
    AK291667, AL360001, BC001595, BU618027, DB164777
    UniProtKB/TrEMBL
    A8K6K2
    Conserved Domains (1) summary
    pfam05761
    Location:27 → 457
    5_nucleotid; 5' nucleotidase family

  9. NM_001351176.2 → NP_001338105.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BU618027, DA724300
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  10. NM_001351177.2 → NP_001338106.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BU618027, DA201591, DB169780
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  11. NM_001351178.2 → NP_001338107.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BU618027, DA343552, DA408606, DB169780
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  12. NM_001351179.2 → NP_001338108.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BE936228, BU618027, BU622015, BX648078, DA215274
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  13. NM_001351180.2 → NP_001338109.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, AL040624, BC001595, BU618027, BX648078, DA493263, DB169780, DB178099
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  14. NM_001351181.2 → NP_001338110.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BU618027, DB127914, DB169780, DB443441
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  15. NM_001351182.2 → NP_001338111.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BE936228, BU618027, BX648078, DA184708, DA724300
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  16. NM_001351183.2 → NP_001338112.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BU618027, DA208418, DB169780, DB178099, DB261846
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  17. NM_001351184.2 → NP_001338113.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BE936228, BU618027, BX648078, DA724300, DB169780
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  18. NM_001351185.2 → NP_001338114.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BE936228, BU618027, BX648078, DA724300, DB169780
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  19. NM_001351186.2 → NP_001338115.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BE936228, BU618027, BX648078, DA223605, DA724300, DB169780
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  20. NM_001351187.2 → NP_001338116.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BE936228, BU618027, BX648078, DA223605, DA408606, DA724300, DB169780
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  21. NM_001351188.2 → NP_001338117.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BE936228, BU618027, BX648078, DA335453, DB169780
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  22. NM_001351189.2 → NP_001338118.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BE936228, BU618027, BU622015, BX648078, DA746739, DB178099, DB261846
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  23. NM_001351190.2 → NP_001338119.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BU618027, BU622015, BX648078, DB178099, DB261846, DB287849
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  24. NM_001351191.1 → NP_001338120.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BU618027, DA201591, DB127914, DC348363
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  25. NM_001351192.1 → NP_001338121.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BU618027, DB097637, DB127914, DC348363
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  26. NM_001351193.1 → NP_001338122.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BP212875, BU618027, DB097637, DB127914, DC348363
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  27. NM_001351194.2 → NP_001338123.1  cytosolic purine 5'-nucleotidase isoform 6

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BU618027, DA208418, DB169780, DB178099, DB261846
    Conserved Domains (1) summary
    cl17687
    Location:1 → 250
    5_nucleotid; 5' nucleotidase family

  28. NM_001351195.2 → NP_001338124.1  cytosolic purine 5'-nucleotidase isoform 6

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BU618027, DA184708, DA208418, DB178099, DB261846
    Conserved Domains (1) summary
    cl17687
    Location:1 → 250
    5_nucleotid; 5' nucleotidase family

  29. NM_001351196.2 → NP_001338125.1  cytosolic purine 5'-nucleotidase isoform 6

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BU618027, DA208418, DA223605, DB169780, DB178099, DB261846
    Conserved Domains (1) summary
    cl17687
    Location:1 → 250
    5_nucleotid; 5' nucleotidase family

  30. NM_001351197.2 → NP_001338126.1  cytosolic purine 5'-nucleotidase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AK291667, BC001595, BU618027, DA408606, DA724300, DB169780
    Conserved Domains (1) summary
    cl17687
    Location:1 → 297
    5_nucleotid; 5' nucleotidase family

  31. NM_012229.5 → NP_036361.1  cytosolic purine 5'-nucleotidase isoform 1

    See identical proteins and their annotated locations for NP_036361.1

    Status: REVIEWED

    Source sequence(s)
    BC001595, BU618027, DA879821
    Consensus CDS
    CCDS7544.1
    UniProtKB/Swiss-Prot
    B7Z382, D3DR91, P49902, Q5JUV5
    UniProtKB/TrEMBL
    A0A384MED8, A8K6K2
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 488
    5_nucleotid; 5' nucleotidase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    103088017..103193272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424854.1 → XP_047280810.1  cytosolic purine 5'-nucleotidase isoform X8

    UniProtKB/TrEMBL
    A8K6K2

  2. XM_047424852.1 → XP_047280808.1  cytosolic purine 5'-nucleotidase isoform X7

    UniProtKB/TrEMBL
    A8K6K2

  3. XM_047424856.1 → XP_047280812.1  cytosolic purine 5'-nucleotidase isoform X8

    UniProtKB/TrEMBL
    A8K6K2

  4. XM_047424853.1 → XP_047280809.1  cytosolic purine 5'-nucleotidase isoform X7

    UniProtKB/TrEMBL
    A8K6K2

  5. XM_047424855.1 → XP_047280811.1  cytosolic purine 5'-nucleotidase isoform X8

    UniProtKB/TrEMBL
    A8K6K2

  6. XM_011539537.2 → XP_011537839.1  cytosolic purine 5'-nucleotidase isoform X7

    UniProtKB/TrEMBL
    A8K6K2
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 439
    5_nucleotid; 5' nucleotidase family

  7. XM_047424845.1 → XP_047280801.1  cytosolic purine 5'-nucleotidase isoform X1

    UniProtKB/TrEMBL
    A0A6Q8PHP0, A8K6K2

  8. XM_047424847.1 → XP_047280803.1  cytosolic purine 5'-nucleotidase isoform X2

    UniProtKB/Swiss-Prot
    B7Z382, D3DR91, P49902, Q5JUV5
    UniProtKB/TrEMBL
    A0A384MED8, A8K6K2

  9. XM_024447901.2 → XP_024303669.1  cytosolic purine 5'-nucleotidase isoform X1

    UniProtKB/TrEMBL
    A0A6Q8PHP0, A8K6K2
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 496
    5_nucleotid; 5' nucleotidase family

  10. XM_047424850.1 → XP_047280806.1  cytosolic purine 5'-nucleotidase isoform X2

    UniProtKB/Swiss-Prot
    B7Z382, D3DR91, P49902, Q5JUV5
    UniProtKB/TrEMBL
    A0A384MED8, A8K6K2

  11. XM_047424846.1 → XP_047280802.1  cytosolic purine 5'-nucleotidase isoform X1

    UniProtKB/TrEMBL
    A0A6Q8PHP0, A8K6K2

  12. XM_047424849.1 → XP_047280805.1  cytosolic purine 5'-nucleotidase isoform X2

    UniProtKB/Swiss-Prot
    B7Z382, D3DR91, P49902, Q5JUV5
    UniProtKB/TrEMBL
    A0A384MED8, A8K6K2

  13. XM_047424844.1 → XP_047280800.1  cytosolic purine 5'-nucleotidase isoform X1

    UniProtKB/TrEMBL
    A0A6Q8PHP0, A8K6K2

  14. XM_047424848.1 → XP_047280804.1  cytosolic purine 5'-nucleotidase isoform X2

    UniProtKB/Swiss-Prot
    B7Z382, D3DR91, P49902, Q5JUV5
    UniProtKB/TrEMBL
    A0A384MED8, A8K6K2

  15. XM_024447902.2 → XP_024303670.1  cytosolic purine 5'-nucleotidase isoform X2

    UniProtKB/Swiss-Prot
    B7Z382, D3DR91, P49902, Q5JUV5
    UniProtKB/TrEMBL
    A0A384MED8, A8K6K2
    Conserved Domains (1) summary
    pfam05761
    Location:43 → 488
    5_nucleotid; 5' nucleotidase family

  16. XM_005269637.6 → XP_005269694.1  cytosolic purine 5'-nucleotidase isoform X3

    See identical proteins and their annotated locations for XP_005269694.1

    UniProtKB/TrEMBL
    A8K6K2
    Conserved Domains (1) summary
    pfam05761
    Location:14 → 467
    5_nucleotid; 5' nucleotidase family

  17. XM_047424851.1 → XP_047280807.1  cytosolic purine 5'-nucleotidase isoform X5

    UniProtKB/TrEMBL
    A8K6K2

  18. XM_047424857.1 → XP_047280813.1  cytosolic purine 5'-nucleotidase isoform X9

  19. XM_047424858.1 → XP_047280814.1  cytosolic purine 5'-nucleotidase isoform X9

  20. XM_017015947.3 → XP_016871436.1  cytosolic purine 5'-nucleotidase isoform X4

    UniProtKB/TrEMBL
    A8K6K2
    Conserved Domains (1) summary
    pfam05761
    Location:27 → 465
    5_nucleotid; 5' nucleotidase family

  21. XM_024447903.2 → XP_024303671.1  cytosolic purine 5'-nucleotidase isoform X6

    UniProtKB/TrEMBL
    A8K6K2
    Conserved Domains (1) summary
    pfam05761
    Location:24 → 452
    5_nucleotid; 5' nucleotidase family

  22. XM_047424859.1 → XP_047280815.1  cytosolic purine 5'-nucleotidase isoform X9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    103974258..104079521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365254.1 → XP_054221229.1  cytosolic purine 5'-nucleotidase isoform X8

    UniProtKB/TrEMBL
    A8K6K2

  2. XM_054365252.1 → XP_054221227.1  cytosolic purine 5'-nucleotidase isoform X7

    UniProtKB/TrEMBL
    A8K6K2

  3. XM_054365256.1 → XP_054221231.1  cytosolic purine 5'-nucleotidase isoform X8

    UniProtKB/TrEMBL
    A8K6K2

  4. XM_054365253.1 → XP_054221228.1  cytosolic purine 5'-nucleotidase isoform X7

    UniProtKB/TrEMBL
    A8K6K2

  5. XM_054365255.1 → XP_054221230.1  cytosolic purine 5'-nucleotidase isoform X8

    UniProtKB/TrEMBL
    A8K6K2

  6. XM_054365251.1 → XP_054221226.1  cytosolic purine 5'-nucleotidase isoform X7

    UniProtKB/TrEMBL
    A8K6K2

  7. XM_054365240.1 → XP_054221215.1  cytosolic purine 5'-nucleotidase isoform X1

    UniProtKB/TrEMBL
    A0A6Q8PHP0, A8K6K2

  8. XM_054365243.1 → XP_054221218.1  cytosolic purine 5'-nucleotidase isoform X2

    UniProtKB/Swiss-Prot
    B7Z382, D3DR91, P49902, Q5JUV5
    UniProtKB/TrEMBL
    A0A384MED8, A8K6K2

  9. XM_054365239.1 → XP_054221214.1  cytosolic purine 5'-nucleotidase isoform X1

    UniProtKB/TrEMBL
    A0A6Q8PHP0, A8K6K2

  10. XM_054365246.1 → XP_054221221.1  cytosolic purine 5'-nucleotidase isoform X2

    UniProtKB/Swiss-Prot
    B7Z382, D3DR91, P49902, Q5JUV5
    UniProtKB/TrEMBL
    A0A384MED8, A8K6K2

  11. XM_054365241.1 → XP_054221216.1  cytosolic purine 5'-nucleotidase isoform X1

    UniProtKB/TrEMBL
    A0A6Q8PHP0, A8K6K2

  12. XM_054365245.1 → XP_054221220.1  cytosolic purine 5'-nucleotidase isoform X2

    UniProtKB/Swiss-Prot
    B7Z382, D3DR91, P49902, Q5JUV5
    UniProtKB/TrEMBL
    A0A384MED8, A8K6K2

  13. XM_054365238.1 → XP_054221213.1  cytosolic purine 5'-nucleotidase isoform X1

    UniProtKB/TrEMBL
    A0A6Q8PHP0, A8K6K2

  14. XM_054365244.1 → XP_054221219.1  cytosolic purine 5'-nucleotidase isoform X2

    UniProtKB/Swiss-Prot
    B7Z382, D3DR91, P49902, Q5JUV5
    UniProtKB/TrEMBL
    A0A384MED8, A8K6K2

  15. XM_054365242.1 → XP_054221217.1  cytosolic purine 5'-nucleotidase isoform X2

    UniProtKB/Swiss-Prot
    B7Z382, D3DR91, P49902, Q5JUV5
    UniProtKB/TrEMBL
    A0A384MED8, A8K6K2

  16. XM_054365247.1 → XP_054221222.1  cytosolic purine 5'-nucleotidase isoform X3

    UniProtKB/TrEMBL
    A8K6K2

  17. XM_054365249.1 → XP_054221224.1  cytosolic purine 5'-nucleotidase isoform X5

    UniProtKB/TrEMBL
    A8K6K2

  18. XM_054365257.1 → XP_054221232.1  cytosolic purine 5'-nucleotidase isoform X9

  19. XM_054365248.1 → XP_054221223.1  cytosolic purine 5'-nucleotidase isoform X4

    UniProtKB/TrEMBL
    A8K6K2

  20. XM_054365250.1 → XP_054221225.1  cytosolic purine 5'-nucleotidase isoform X6

    UniProtKB/TrEMBL
    A8K6K2

  21. XM_054365258.1 → XP_054221233.1  cytosolic purine 5'-nucleotidase isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49902.1 GenPept UniProtKB/Swiss-Prot:P49902

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