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WDFY3 WD repeat and FYVE domain containing 3 [ Homo sapiens (human) ]

Gene ID: 23001, updated on 3-Nov-2024

Summary

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Official Symbol
WDFY3provided by HGNC
Official Full Name
WD repeat and FYVE domain containing 3provided by HGNC
Primary source
HGNC:HGNC:20751
See related
Ensembl:ENSG00000163625 MIM:617485; AllianceGenome:HGNC:20751
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALFY; BCHS; MCPH18; ZFYVE25
Summary
This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in kidney (RPKM 8.6), brain (RPKM 8.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See WDFY3 in Genome Data Viewer
Location:
4q21.23
Exon count:
74
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (84669597..84966690, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (87999582..88296708, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (85590750..85887843, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:85504073-85505026 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:85517394-85518371 Neighboring gene Sharpr-MPRA regulatory region 8979 Neighboring gene uncharacterized LOC124900854 Neighboring gene CDP-diacylglycerol synthase 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:85612241-85613440 Neighboring gene RNA, 7SL, cytoplasmic 552, pseudogene Neighboring gene WDFY3 antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:85777520-85778150 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:85791021-85791555 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:85791556-85792089 Neighboring gene RNA, U6 small nuclear 469, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:85848560-85849074 Neighboring gene WDFY3 antisense RNA 2 Neighboring gene RN7SK pseudogene 48 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:86087809-86088309 Neighboring gene quinone oxidoreductase-like protein 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The autophagy scaffold protein ALFY is critical for the granulocytic differentiation of AML cells. Schläfli AM, et al. Sci Rep, 2017 Oct 11. PMID 29021535, Free PMC Article
  2. Alfy-dependent elimination of aggregated proteins by macroautophagy: can there be too much of a good thing? Yamamoto A, et al. Autophagy, 2011 Mar. PMID 21150266, Free PMC Article
  3. ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration. Søreng K, et al. J Cell Sci, 2022 Feb 15. PMID 35099014, Free PMC Article
  4. A master conductor for aggregate clearance by autophagy. Deretic V. Dev Cell, 2010 May 18. PMID 20493804, Free PMC Article
  5. Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size. Le Duc D, et al. Brain, 2019 Sep 1. PMID 31327001, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis.
    Title: A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis.
  2. ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration.
    Title: ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration.
  3. A highly conserved glutamic acid in ALFY inhibits membrane binding to aid in aggregate clearance.
    Title: A highly conserved glutamic acid in ALFY inhibits membrane binding to aid in aggregate clearance.
  4. Alfy is required in the adult brain for the autophagy-dependent clearance of proteinaceous deposits, and its depletion in neurons derived from Huntington's disease patient fibroblasts accelerates the aberrant accumulation of this pathological hallmark shared across adult-onset neurodegenerative diseases.
    Title: Huntington's Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3 and Selective Macroautophagy.
  5. Proliferating cortical neural progenitors of human embryonic brain regions highly express WDFY3.
    Title: Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size.
  6. a crucial role for ALFY in retinoid triggered maturation of acute myeloid leukemia cells, is reported.
    Title: The autophagy scaffold protein ALFY is critical for the granulocytic differentiation of AML cells.
  7. The Autophagy linked FYVE protein (Alfy), also known as WDFY3, is required for development of the central nervous system (CNS) in mice.
    Title: Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain.
  8. we demonstrate that normally ALFY attenuates the canonical Wnt signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 or Dvl2.
    Title: ALFY-Controlled DVL3 Autophagy Regulates Wnt Signaling, Determining Human Brain Size.
  9. ALFY binds selectively to LC3C and the GABARAPs through a LC3-interacting region in its WD40 domain.
    Title: Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.
  10. increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others
    Title: Alfy-dependent elimination of aggregated proteins by macroautophagy: can there be too much of a good thing?
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Microcephaly 18, primary, autosomal dominant
MedGen: C4479608 OMIM: 617520 GeneReviews: Not available
not available

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2023-10-10)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2023-10-10)

ClinGen Genome Curation PagePubMed

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0993, MGC16461

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in aggrephagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aggrephagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Atg12-Atg5-Atg16 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in PML body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in autophagosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in autophagosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in inclusion body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
WD repeat and FYVE domain-containing protein 3
Names
autophagy-linked FYVE protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046917.1 RefSeqGene

    Range
    4702..301795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014991.6 → NP_055806.2  WD repeat and FYVE domain-containing protein 3

    See identical proteins and their annotated locations for NP_055806.2

    Status: REVIEWED

    Source sequence(s)
    AC095046, AC104082, AC108021
    Consensus CDS
    CCDS3609.1
    UniProtKB/Swiss-Prot
    Q4W5K5, Q6P0Q5, Q8IZQ1, Q8N1T2, Q8NAV6, Q96BS7, Q96D33, Q96N85, Q9Y2J7
    UniProtKB/TrEMBL
    H0Y9T6
    Related
    ENSP00000295888.4, ENST00000295888.9
    Conserved Domains (7) summary
    smart01026
    Location:2695 → 2976
    Beach; Beige/BEACH domain
    COG2319
    Location:3044 → 3247
    WD40; WD40 repeat [General function prediction only]
    cd01201
    Location:2534 → 2657
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    cd15719
    Location:3449 → 3513
    FYVE_WDFY3; FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar proteins
    pfam15787
    Location:1434 → 1554
    DUF4704; Domain of unknown function (DUF4704)
    sd00039
    Location:3084 → 3125
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3084 → 3246
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    84669597..84966690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531759.3 → XP_011530061.1  WD repeat and FYVE domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011530061.1

    UniProtKB/TrEMBL
    H0Y9T6
    Conserved Domains (7) summary
    smart01026
    Location:2713 → 2994
    Beach; Beige/BEACH domain
    COG2319
    Location:3062 → 3265
    WD40; WD40 repeat [General function prediction only]
    cd01201
    Location:2552 → 2675
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    cd15719
    Location:3467 → 3531
    FYVE_WDFY3; FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar proteins
    pfam15787
    Location:1452 → 1572
    DUF4704; Domain of unknown function (DUF4704)
    sd00039
    Location:3102 → 3143
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3102 → 3264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_047449858.1 → XP_047305814.1  WD repeat and FYVE domain-containing protein 3 isoform X10

  3. XM_011531763.4 → XP_011530065.1  WD repeat and FYVE domain-containing protein 3 isoform X4

    See identical proteins and their annotated locations for XP_011530065.1

    UniProtKB/Swiss-Prot
    Q4W5K5, Q6P0Q5, Q8IZQ1, Q8N1T2, Q8NAV6, Q96BS7, Q96D33, Q96N85, Q9Y2J7
    UniProtKB/TrEMBL
    H0Y9T6
    Conserved Domains (7) summary
    smart01026
    Location:2695 → 2976
    Beach; Beige/BEACH domain
    COG2319
    Location:3044 → 3247
    WD40; WD40 repeat [General function prediction only]
    cd01201
    Location:2534 → 2657
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    cd15719
    Location:3449 → 3513
    FYVE_WDFY3; FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar proteins
    pfam15787
    Location:1434 → 1554
    DUF4704; Domain of unknown function (DUF4704)
    sd00039
    Location:3084 → 3125
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3084 → 3246
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_011531760.4 → XP_011530062.1  WD repeat and FYVE domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011530062.1

    UniProtKB/TrEMBL
    H0Y9T6
    Conserved Domains (7) summary
    smart01026
    Location:2713 → 2994
    Beach; Beige/BEACH domain
    COG2319
    Location:3062 → 3265
    WD40; WD40 repeat [General function prediction only]
    cd01201
    Location:2552 → 2675
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    cd15719
    Location:3467 → 3531
    FYVE_WDFY3; FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar proteins
    pfam15787
    Location:1452 → 1572
    DUF4704; Domain of unknown function (DUF4704)
    sd00039
    Location:3102 → 3143
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3102 → 3264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_047449859.1 → XP_047305815.1  WD repeat and FYVE domain-containing protein 3 isoform X11

  6. XM_047449857.1 → XP_047305813.1  WD repeat and FYVE domain-containing protein 3 isoform X10

  7. XM_047449854.1 → XP_047305810.1  WD repeat and FYVE domain-containing protein 3 isoform X7

    Related
    ENSP00000424987.2, ENST00000514711.2

  8. XM_047449855.1 → XP_047305811.1  WD repeat and FYVE domain-containing protein 3 isoform X8

  9. XM_047449856.1 → XP_047305812.1  WD repeat and FYVE domain-containing protein 3 isoform X9

  10. XM_011531764.4 → XP_011530066.1  WD repeat and FYVE domain-containing protein 3 isoform X5

    UniProtKB/TrEMBL
    H0Y9T6
    Conserved Domains (7) summary
    smart01026
    Location:2685 → 2966
    Beach; Beige/BEACH domain
    COG2319
    Location:3034 → 3237
    WD40; WD40 repeat [General function prediction only]
    cd01201
    Location:2524 → 2647
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    cd15719
    Location:3439 → 3503
    FYVE_WDFY3; FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar proteins
    pfam15787
    Location:1424 → 1544
    DUF4704; Domain of unknown function (DUF4704)
    sd00039
    Location:3074 → 3115
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3074 → 3236
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  11. XM_047449853.1 → XP_047305809.1  WD repeat and FYVE domain-containing protein 3 isoform X6

  12. XM_011531761.4 → XP_011530063.1  WD repeat and FYVE domain-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    H0Y9T6
    Conserved Domains (7) summary
    smart01026
    Location:2698 → 2979
    Beach; Beige/BEACH domain
    COG2319
    Location:3047 → 3250
    WD40; WD40 repeat [General function prediction only]
    cd01201
    Location:2537 → 2660
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    cd15719
    Location:3452 → 3516
    FYVE_WDFY3; FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar proteins
    pfam15787
    Location:1452 → 1572
    DUF4704; Domain of unknown function (DUF4704)
    sd00039
    Location:3087 → 3128
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3087 → 3249
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  13. XM_011531762.4 → XP_011530064.1  WD repeat and FYVE domain-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    H0Y9T6
    Conserved Domains (7) summary
    smart01026
    Location:2696 → 2977
    Beach; Beige/BEACH domain
    COG2319
    Location:3045 → 3248
    WD40; WD40 repeat [General function prediction only]
    cd01201
    Location:2535 → 2658
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    cd15719
    Location:3450 → 3514
    FYVE_WDFY3; FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar proteins
    pfam15787
    Location:1452 → 1572
    DUF4704; Domain of unknown function (DUF4704)
    sd00039
    Location:3085 → 3126
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3085 → 3247
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  14. XM_011531757.4 → XP_011530059.1  WD repeat and FYVE domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011530059.1

    UniProtKB/TrEMBL
    H0Y9T6
    Conserved Domains (7) summary
    smart01026
    Location:2713 → 2994
    Beach; Beige/BEACH domain
    COG2319
    Location:3062 → 3265
    WD40; WD40 repeat [General function prediction only]
    cd01201
    Location:2552 → 2675
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    cd15719
    Location:3467 → 3531
    FYVE_WDFY3; FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar proteins
    pfam15787
    Location:1452 → 1572
    DUF4704; Domain of unknown function (DUF4704)
    sd00039
    Location:3102 → 3143
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3102 → 3264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  15. XM_047449851.1 → XP_047305807.1  WD repeat and FYVE domain-containing protein 3 isoform X4

    UniProtKB/Swiss-Prot
    Q4W5K5, Q6P0Q5, Q8IZQ1, Q8N1T2, Q8NAV6, Q96BS7, Q96D33, Q96N85, Q9Y2J7

  16. XM_005262858.6 → XP_005262915.1  WD repeat and FYVE domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005262915.1

    UniProtKB/TrEMBL
    H0Y9T6
    Conserved Domains (7) summary
    smart01026
    Location:2713 → 2994
    Beach; Beige/BEACH domain
    COG2319
    Location:3062 → 3265
    WD40; WD40 repeat [General function prediction only]
    cd01201
    Location:2552 → 2675
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    cd15719
    Location:3467 → 3531
    FYVE_WDFY3; FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar proteins
    pfam15787
    Location:1452 → 1572
    DUF4704; Domain of unknown function (DUF4704)
    sd00039
    Location:3102 → 3143
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3102 → 3264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  17. XM_017007908.3 → XP_016863397.1  WD repeat and FYVE domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    H0Y9T6
    Conserved Domains (7) summary
    smart01026
    Location:2713 → 2994
    Beach; Beige/BEACH domain
    COG2319
    Location:3062 → 3265
    WD40; WD40 repeat [General function prediction only]
    cd01201
    Location:2552 → 2675
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    cd15719
    Location:3467 → 3531
    FYVE_WDFY3; FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar proteins
    pfam15787
    Location:1452 → 1572
    DUF4704; Domain of unknown function (DUF4704)
    sd00039
    Location:3102 → 3143
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3102 → 3264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  18. XM_047449850.1 → XP_047305806.1  WD repeat and FYVE domain-containing protein 3 isoform X1

  19. XM_047449846.1 → XP_047305802.1  WD repeat and FYVE domain-containing protein 3 isoform X1

  20. XM_047449847.1 → XP_047305803.1  WD repeat and FYVE domain-containing protein 3 isoform X1

  21. XM_047449848.1 → XP_047305804.1  WD repeat and FYVE domain-containing protein 3 isoform X1

  22. XM_047449849.1 → XP_047305805.1  WD repeat and FYVE domain-containing protein 3 isoform X1

  23. XM_017007907.3 → XP_016863396.1  WD repeat and FYVE domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    H0Y9T6
    Conserved Domains (7) summary
    smart01026
    Location:2713 → 2994
    Beach; Beige/BEACH domain
    COG2319
    Location:3062 → 3265
    WD40; WD40 repeat [General function prediction only]
    cd01201
    Location:2552 → 2675
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    cd15719
    Location:3467 → 3531
    FYVE_WDFY3; FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar proteins
    pfam15787
    Location:1452 → 1572
    DUF4704; Domain of unknown function (DUF4704)
    sd00039
    Location:3102 → 3143
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3102 → 3264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  24. XM_017007906.3 → XP_016863395.1  WD repeat and FYVE domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    H0Y9T6
    Conserved Domains (7) summary
    smart01026
    Location:2713 → 2994
    Beach; Beige/BEACH domain
    COG2319
    Location:3062 → 3265
    WD40; WD40 repeat [General function prediction only]
    cd01201
    Location:2552 → 2675
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    cd15719
    Location:3467 → 3531
    FYVE_WDFY3; FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar proteins
    pfam15787
    Location:1452 → 1572
    DUF4704; Domain of unknown function (DUF4704)
    sd00039
    Location:3102 → 3143
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3102 → 3264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  25. XM_047449852.1 → XP_047305808.1  WD repeat and FYVE domain-containing protein 3 isoform X4

    UniProtKB/Swiss-Prot
    Q4W5K5, Q6P0Q5, Q8IZQ1, Q8N1T2, Q8NAV6, Q96BS7, Q96D33, Q96N85, Q9Y2J7

  26. XM_047449860.1 → XP_047305816.1  WD repeat and FYVE domain-containing protein 3 isoform X1

  27. XM_011531766.3 → XP_011530068.1  WD repeat and FYVE domain-containing protein 3 isoform X12

    Conserved Domains (2) summary
    pfam15787
    Location:1452 → 1572
    DUF4704; Domain of unknown function (DUF4704)
    cl22861
    Location:1209 → 1268
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  28. XM_011531767.3 → XP_011530069.1  WD repeat and FYVE domain-containing protein 3 isoform X13

    Conserved Domains (2) summary
    pfam15787
    Location:1452 → 1572
    DUF4704; Domain of unknown function (DUF4704)
    cl22861
    Location:1209 → 1268
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    87999582..88296708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349317.1 → XP_054205292.1  WD repeat and FYVE domain-containing protein 3 isoform X1

  2. XM_054349334.1 → XP_054205309.1  WD repeat and FYVE domain-containing protein 3 isoform X10

  3. XM_054349326.1 → XP_054205301.1  WD repeat and FYVE domain-containing protein 3 isoform X4

    UniProtKB/Swiss-Prot
    Q4W5K5, Q6P0Q5, Q8IZQ1, Q8N1T2, Q8NAV6, Q96BS7, Q96D33, Q96N85, Q9Y2J7

  4. XM_054349336.1 → XP_054205311.1  WD repeat and FYVE domain-containing protein 3 isoform X1

  5. XM_054349333.1 → XP_054205308.1  WD repeat and FYVE domain-containing protein 3 isoform X10

  6. XM_054349316.1 → XP_054205291.1  WD repeat and FYVE domain-containing protein 3 isoform X1

  7. XM_054349325.1 → XP_054205300.1  WD repeat and FYVE domain-containing protein 3 isoform X4

    UniProtKB/Swiss-Prot
    Q4W5K5, Q6P0Q5, Q8IZQ1, Q8N1T2, Q8NAV6, Q96BS7, Q96D33, Q96N85, Q9Y2J7

  8. XM_054349327.1 → XP_054205302.1  WD repeat and FYVE domain-containing protein 3 isoform X4

    UniProtKB/Swiss-Prot
    Q4W5K5, Q6P0Q5, Q8IZQ1, Q8N1T2, Q8NAV6, Q96BS7, Q96D33, Q96N85, Q9Y2J7

  9. XM_054349330.1 → XP_054205305.1  WD repeat and FYVE domain-containing protein 3 isoform X7

  10. XM_054349331.1 → XP_054205306.1  WD repeat and FYVE domain-containing protein 3 isoform X8

  11. XM_054349332.1 → XP_054205307.1  WD repeat and FYVE domain-containing protein 3 isoform X9

  12. XM_054349328.1 → XP_054205303.1  WD repeat and FYVE domain-containing protein 3 isoform X5

  13. XM_054349329.1 → XP_054205304.1  WD repeat and FYVE domain-containing protein 3 isoform X6

  14. XM_054349323.1 → XP_054205298.1  WD repeat and FYVE domain-containing protein 3 isoform X2

  15. XM_054349324.1 → XP_054205299.1  WD repeat and FYVE domain-containing protein 3 isoform X3

  16. XM_054349320.1 → XP_054205295.1  WD repeat and FYVE domain-containing protein 3 isoform X1

  17. XM_054349322.1 → XP_054205297.1  WD repeat and FYVE domain-containing protein 3 isoform X1

  18. XM_054349319.1 → XP_054205294.1  WD repeat and FYVE domain-containing protein 3 isoform X1

  19. XM_054349318.1 → XP_054205293.1  WD repeat and FYVE domain-containing protein 3 isoform X1

  20. XM_054349335.1 → XP_054205310.1  WD repeat and FYVE domain-containing protein 3 isoform X11

  21. XM_054349321.1 → XP_054205296.1  WD repeat and FYVE domain-containing protein 3 isoform X1

  22. XM_054349337.1 → XP_054205312.1  WD repeat and FYVE domain-containing protein 3 isoform X12

  23. XM_054349338.1 → XP_054205313.1  WD repeat and FYVE domain-containing protein 3 isoform X13

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178583.2: Suppressed sequence

    Description
    NM_178583.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_178585.2: Suppressed sequence

    Description
    NM_178585.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZQ1.2 GenPept UniProtKB/Swiss-Prot:Q8IZQ1

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