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Glis1 GLIS family zinc finger 1 [ Mus musculus (house mouse) ]

Gene ID: 230587, updated on 13-Jan-2025

Summary

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Official Symbol
Glis1provided by MGI
Official Full Name
GLIS family zinc finger 1provided by MGI
Primary source
MGI:MGI:2386723
See related
Ensembl:ENSMUSG00000034762 AllianceGenome:MGI:2386723
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gli5; Gli6; GliH1
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including fat cell differentiation; osteoblast differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; heart and pericardium; sensory organ; and skin. Orthologous to human GLIS1 (GLIS family zinc finger 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in kidney adult (RPKM 4.5), limb E14.5 (RPKM 2.5) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Glis1 in Genome Data Viewer
Location:
4 C7; 4 50.18 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (107283840..107492258)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107426636..107635061)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Yip1 domain family, member 1 Neighboring gene replication factor C (activator 1) 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_11024 Neighboring gene STARR-positive B cell enhancer ABC_E10245 Neighboring gene NDC1 transmembrane nucleoporin Neighboring gene RIKEN cDNA 4930552P06 gene Neighboring gene STARR-seq mESC enhancer starr_11025 Neighboring gene predicted gene, 52673 Neighboring gene RIKEN cDNA 1700047F07 gene Neighboring gene STARR-seq mESC enhancer starr_11026 Neighboring gene DMRT-like family B with proline-rich C-terminal, 1 Neighboring gene predicted gene 12899 Neighboring gene predicted gene, 57502

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans. Nair KS, et al. Nat Commun, 2021 Aug 12. PMID 34385434, Free PMC Article
  2. Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade. Li L, et al. Nat Metab, 2020 Sep. PMID 32839595
  3. GLIS1 intervention enhances anti-PD1 therapy for hepatocellular carcinoma by targeting SGK1-STAT3-PD1 pathway. Rong D, et al. J Immunother Cancer, 2023 Feb. PMID 36787938, Free PMC Article
  4. Genome-Wide Association Study-Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse. Yu M, et al. Circ Genom Precis Med, 2019 May. PMID 31112420, Free PMC Article
  5. Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells. Tosic M, et al. Nat Commun, 2018 Jan 25. PMID 29371665, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GLIS1 intervention enhances anti-PD1 therapy for hepatocellular carcinoma by targeting SGK1-STAT3-PD1 pathway.
    Title: GLIS1 intervention enhances anti-PD1 therapy for hepatocellular carcinoma by targeting SGK1-STAT3-PD1 pathway.
  2. GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans.
    Title: GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans.
  3. RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6.
    Title: RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6.
  4. Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade.
    Title: Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade.
  5. Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation.
    Title: Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation.
  6. Glis1 is expressed during embryonic development predominantly in nuclei of endothelial and interstitial cells of mitral valves in mouse.
    Title: Genome-Wide Association Study-Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse.
  7. Identification of aryl hydrocarbon receptor and Glis family zinc finger 1 as mesenchymal key transcription factors controlled by dynamic cell type-specific super-enhancers that become repressed during differentiation toward adipocytes and osteoblasts.
    Title: Temporal enhancer profiling of parallel lineages identifies AHR and GLIS1 as regulators of mesenchymal multipotency.
  8. Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells into myocytes while preventing brown adipocyte differentiation of satellite cells via repressing expression of the novel pro-adipogenic transcription factor Glis1.
    Title: Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells.
  9. results therefore show that Glis1 effectively promotes the direct reprogramming of somatic cells during iPSC generation.
    Title: Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1.
  10. GliH1 has homology to the Gli zinc finger domain but is not required for mouse development
    Title: A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein GLIS1
Names
GLI-Kruppel family member GLI6
GLI-similar 1
Glis1 Kruppel-like zinc finger protein
gli homologous protein 1
zinc finger transcription factor Gli5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_147221.2 → NP_671754.2  zinc finger protein GLIS1

    See identical proteins and their annotated locations for NP_671754.2

    Status: VALIDATED

    Source sequence(s)
    AK145342, AL626784, AL627259, BC066157
    Consensus CDS
    CCDS38831.1
    UniProtKB/Swiss-Prot
    Q6NZF6, Q8K1M4, Q8R4Z3
    UniProtKB/TrEMBL
    H6WAT1
    Related
    ENSMUSP00000035650.3, ENSMUST00000046005.9
    Conserved Domains (2) summary
    COG5048
    Location:431 → 510
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:435 → 457
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    107283840..107492258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502972.4 → XP_006503035.1  zinc finger protein GLIS1 isoform X2

    UniProtKB/TrEMBL
    H6WAT1
    Conserved Domains (2) summary
    COG5048
    Location:446 → 525
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:450 → 472
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006502973.5 → XP_006503036.1  zinc finger protein GLIS1 isoform X3

    See identical proteins and their annotated locations for XP_006503036.1

    UniProtKB/Swiss-Prot
    Q6NZF6, Q8K1M4, Q8R4Z3
    UniProtKB/TrEMBL
    H6WAT1
    Conserved Domains (2) summary
    COG5048
    Location:431 → 510
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:435 → 457
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_030253436.2 → XP_030109296.1  zinc finger protein GLIS1 isoform X4

    UniProtKB/TrEMBL
    H6WAT1
    Conserved Domains (2) summary
    COG5048
    Location:431 → 525
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:435 → 457
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_006502974.5 → XP_006503037.1  zinc finger protein GLIS1 isoform X3

    See identical proteins and their annotated locations for XP_006503037.1

    UniProtKB/Swiss-Prot
    Q6NZF6, Q8K1M4, Q8R4Z3
    UniProtKB/TrEMBL
    H6WAT1
    Conserved Domains (2) summary
    COG5048
    Location:431 → 510
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:435 → 457
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_006502975.2 → XP_006503038.1  zinc finger protein GLIS1 isoform X3

    See identical proteins and their annotated locations for XP_006503038.1

    UniProtKB/Swiss-Prot
    Q6NZF6, Q8K1M4, Q8R4Z3
    UniProtKB/TrEMBL
    H6WAT1
    Conserved Domains (2) summary
    COG5048
    Location:431 → 510
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:435 → 457
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_036164022.1 → XP_036019915.1  zinc finger protein GLIS1 isoform X1

    UniProtKB/TrEMBL
    H6WAT1
    Conserved Domains (1) summary
    sd00017
    Location:372 → 391
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1M4.2 GenPept UniProtKB/Swiss-Prot:Q8K1M4

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