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Nrdc nardilysin convertase [ Mus musculus (house mouse) ]

Gene ID: 230598, updated on 27-May-2024

Summary

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Official Symbol
Nrdcprovided by MGI
Official Full Name
nardilysin convertaseprovided by MGI
Primary source
MGI:MGI:1201386
See related
Ensembl:ENSMUSG00000053510 AllianceGenome:MGI:1201386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nrd1; NRD-C; 2600011I06Rik
Summary
Predicted to enable peptidase activity. Involved in negative regulation of cold-induced thermogenesis. Located in mitochondrion. Is expressed in brain. Orthologous to human NRDC (nardilysin convertase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 91.8), CNS E11.5 (RPKM 25.7) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Nrdc in Genome Data Viewer
Location:
4 C7; 4 50.77 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108857852..108918974)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (109000655..109061777)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:108520274-108520575 Neighboring gene thioredoxin domain containing 12 (endoplasmic reticulum) Neighboring gene KTI12 homolog, chromatin associated Neighboring gene RAB3B, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_11058 Neighboring gene RIKEN cDNA 8030443G20 gene Neighboring gene STARR-seq mESC enhancer starr_11059 Neighboring gene STARR-positive B cell enhancer ABC_E520 Neighboring gene STARR-seq mESC enhancer starr_11060 Neighboring gene microRNA 761 Neighboring gene STARR-seq mESC enhancer starr_11061 Neighboring gene STARR-seq mESC enhancer starr_11062 Neighboring gene oxysterol binding protein-like 9 Neighboring gene predicted gene, 32581 Neighboring gene STARR-positive B cell enhancer mm9_chr4:108777798-108778099 Neighboring gene STARR-positive B cell enhancer ABC_E521 Neighboring gene STARR-positive B cell enhancer ABC_E6198 Neighboring gene STARR-seq mESC enhancer starr_11065 Neighboring gene predicted gene, 52703

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deficiency of Nardilysin in the Liver Reduces Serum Cholesterol Levels. Yasuda D, et al. Biol Pharm Bull, 2021. PMID 33642545
  2. Genome-wide profiling of nardilysin target genes reveals its role in epigenetic regulation and cell cycle progression. Morita Y, et al. Sci Rep, 2017 Nov 1. PMID 29093577, Free PMC Article
  3. Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach. Kimura Y, et al. Sci Rep, 2017 Feb 23. PMID 28230087, Free PMC Article
  4. Nardilysin Is Required for Maintaining Pancreatic β-Cell Function. Nishi K, et al. Diabetes, 2016 Oct. PMID 27385158
  5. Deletion of nardilysin prevents the development of steatohepatitis and liver fibrotic changes. Ishizu-Higashi S, et al. PLoS One, 2014. PMID 24849253, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nardilysin in vascular smooth muscle cells controls blood pressure via the regulation of calcium dynamics.
    Title: Nardilysin in vascular smooth muscle cells controls blood pressure via the regulation of calcium dynamics.
  2. Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer.
    Title: Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer.
  3. Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis.
    Title: Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis.
  4. Deficiency of Nardilysin in the Liver Reduces Serum Cholesterol Levels.
    Title: Deficiency of Nardilysin in the Liver Reduces Serum Cholesterol Levels.
  5. Nardilysin controls cardiac sympathetic innervation patterning through regulation of p75 neurotrophin receptor.
    Title: Nardilysin controls cardiac sympathetic innervation patterning through regulation of p75 neurotrophin receptor.
  6. integrative studies emphasize the importance of Nrdc for maintaining a proper epigenetic status and cell growth.
    Title: Genome-wide profiling of nardilysin target genes reveals its role in epigenetic regulation and cell cycle progression.
  7. Here, the authors have demonstrated that nardilysin regulates gastric inflammation caused by Helicobacter felis infection or forced expression of prostaglandin. Metaplastic changes following gastric inflammation were suppressed by the deletion of nardilysin. Furthremore, the deletion of nardilysin significantly suppressed N-methyl-N-nitrosourea (MNU)-induced gastric tumorigenesis in the murine stomach.
    Title: Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach.
  8. Nardilysin Is Required for Maintaining Pancreatic beta-Cell Function
    Title: Nardilysin Is Required for Maintaining Pancreatic β-Cell Function.
  9. critical regulator of body temperature homoeostasis
    Title: Critical roles of nardilysin in the maintenance of body temperature homoeostasis.
  10. deletion of nardilysin prevents the development of diet-induced steatohepatitis and liver fibrogenesis
    Title: Deletion of nardilysin prevents the development of steatohepatitis and liver fibrotic changes.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC25477

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nardilysin
Names
N-arginine dibasic convertase
NRD convertase
nardilysin, N-arginine dibasic convertase, NRD convertase 1
NP_001333483.1
NP_001334098.1
NP_666262.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346554.1 → NP_001333483.1  nardilysin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL627406, BE949999
    Consensus CDS
    CCDS89800.1
    UniProtKB/TrEMBL
    A6PWC3, Q8R320
    Related
    ENSMUSP00000099797.3, ENSMUST00000102736.9

  2. NM_001347169.2 → NP_001334098.1  nardilysin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL627406, BE949999
    Consensus CDS
    CCDS84773.1
    UniProtKB/TrEMBL
    A2A9Q2, Q8R320
    Related
    ENSMUSP00000102255.3, ENSMUST00000106644.9

  3. NM_146150.3 → NP_666262.2  nardilysin isoform 2 precursor

    See identical proteins and their annotated locations for NP_666262.2

    Status: VALIDATED

    Source sequence(s)
    AK031548, BY732391, CF168810
    Consensus CDS
    CCDS18460.1
    UniProtKB/Swiss-Prot
    Q8BHG1
    UniProtKB/TrEMBL
    Q8R320
    Related
    ENSMUSP00000068328.5, ENSMUST00000065977.11
    Conserved Domains (4) summary
    COG1025
    Location:222 → 1100
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
    pfam00675
    Location:210 → 348
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:373 → 559
    Peptidase_M16_C; Peptidase M16 inactive domain
    pfam16187
    Location:564 → 845
    Peptidase_M16_M; Middle or third domain of peptidase_M16

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    108857852..108918974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHG1.1 GenPept UniProtKB/Swiss-Prot:Q8BHG1

Gene LinkOut

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