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Cox18 cytochrome c oxidase assembly protein 18 [ Mus musculus (house mouse) ]

Gene ID: 231430, updated on 2-Nov-2024

Summary

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Official Symbol
Cox18provided by MGI
Official Full Name
cytochrome c oxidase assembly protein 18provided by MGI
Primary source
MGI:MGI:2448532
See related
Ensembl:ENSMUSG00000035505 AllianceGenome:MGI:2448532
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable membrane insertase activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly and protein insertion into mitochondrial inner membrane from matrix. Located in mitochondrion. Orthologous to human COX18 (cytochrome c oxidase assembly factor COX18). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in adrenal adult (RPKM 58.2), ovary adult (RPKM 20.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Cox18 in Genome Data Viewer
Location:
5 E1; 5 44.32 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (90362583..90371828, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (90214724..90224595, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 5A-like 3, pseudogene Neighboring gene predicted gene, 35936 Neighboring gene STARR-seq mESC enhancer starr_13591 Neighboring gene STARR-positive B cell enhancer ABC_E4763 Neighboring gene STARR-seq mESC enhancer starr_13593 Neighboring gene ankyrin repeat domain 17 Neighboring gene STARR-seq mESC enhancer starr_13595 Neighboring gene STARR-positive B cell enhancer ABC_E10327 Neighboring gene STARR-seq mESC enhancer starr_13598 Neighboring gene predicted gene 9958 Neighboring gene predicted gene, 35999

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables membrane insertase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables membrane insertase activity ISO
Inferred from Sequence Orthology
more info
  
enables membrane insertase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein insertion into mitochondrial inner membrane from matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial inner membrane from matrix ISO
Inferred from Sequence Orthology
more info
  
involved_in protein insertion into mitochondrial inner membrane from matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein insertion into mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein insertion into mitochondrial membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in respiratory chain complex IV assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in respiratory chain complex IV assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
cytochrome c oxidase assembly protein COX18, mitochondrial
Names
COX18 cytochrome c oxidase assembly homolog
mitochondrial inner membrane protein COX18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033310.4 → NP_001028482.2  cytochrome c oxidase assembly protein COX18, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001028482.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, that results in a protein (isoform 2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AC162171
    Consensus CDS
    CCDS19411.1
    UniProtKB/Swiss-Prot
    A6H626, G3X965, Q3U1D5, Q8VC74
    UniProtKB/TrEMBL
    B7ZNW4
    Related
    ENSMUSP00000044144.8, ENSMUST00000048363.10
    Conserved Domains (1) summary
    cl00489
    Location:68 → 296
    60KD_IMP; 60Kd inner membrane protein

  2. NM_001163456.2 → NP_001156928.1  cytochrome c oxidase assembly protein COX18, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001156928.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC162171
    Consensus CDS
    CCDS51543.1
    UniProtKB/TrEMBL
    B7ZNW4, G5E8U6
    Related
    ENSMUSP00000113353.2, ENSMUST00000118816.6
    Conserved Domains (1) summary
    cl00489
    Location:68 → 297
    60KD_IMP; 60Kd inner membrane protein

RNA

  1. NR_028088.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, compared to variant 1, that results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC162171

  2. NR_189627.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC162171

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    90362583..90371828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VC74.5 GenPept UniProtKB/Swiss-Prot:Q8VC74

Gene LinkOut

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