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Tmem150c transmembrane protein 150C [ Mus musculus (house mouse) ]

Gene ID: 231503, updated on 9-Aug-2024

Summary

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Official Symbol
Tmem150cprovided by MGI
Official Full Name
transmembrane protein 150Cprovided by MGI
Primary source
MGI:MGI:3041258
See related
Ensembl:ENSMUSG00000050640 AllianceGenome:MGI:3041258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables mechanosensitive ion channel activity. Involved in cellular response to mechanical stimulus and proprioception. Located in plasma membrane. Is expressed in central nervous system; dorsal root ganglion; and rib. Orthologous to human TMEM150C (transmembrane protein 150C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 33.9), CNS E18 (RPKM 5.4) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem150c in Genome Data Viewer
Location:
5 E4; 5 48.46 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100225731..100313463, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100077872..100165607, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930524J08 gene Neighboring gene STARR-seq mESC enhancer starr_13719 Neighboring gene heterogeneous nuclear ribonucleoprotein D Neighboring gene STARR-positive B cell enhancer ABC_E2161 Neighboring gene STARR-seq mESC enhancer starr_13720 Neighboring gene heterogeneous nuclear ribonucleoprotein D-like Neighboring gene enolase-phosphatase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8822 Neighboring gene transmembrane protein 150C, opposite strand Neighboring gene predicted gene, 36167 Neighboring gene RIKEN cDNA 2310034O05 gene Neighboring gene predicted gene, 36304 Neighboring gene stearoyl-CoA desaturase 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13721 Neighboring gene predicted gene, 42129

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lack of evidence for participation of TMEM150C in sensory mechanotransduction. Ojeda-Alonso J, et al. J Gen Physiol, 2022 Dec 5. PMID 36256908, Free PMC Article
  2. Tentonin 3/TMEM150C regulates glucose-stimulated insulin secretion in pancreatic β-cells. Wee J, et al. Cell Rep, 2021 Nov 30. PMID 34852221
  3. Tentonin 3/TMEM150C senses blood pressure changes in the aortic arch. Lu HJ, et al. J Clin Invest, 2020 Jul 1. PMID 32484458, Free PMC Article
  4. Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function. Hong GS, et al. Neuron, 2016 Jul 6. PMID 27321926
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lack of evidence for participation of TMEM150C in sensory mechanotransduction.
    Title: Lack of evidence for participation of TMEM150C in sensory mechanotransduction.
  2. Tentonin 3/TMEM150C regulates glucose-stimulated insulin secretion in pancreatic beta-cells.
    Title: Tentonin 3/TMEM150C regulates glucose-stimulated insulin secretion in pancreatic β-cells.
  3. Tentonin 3/TMEM150C senses blood pressure changes in the aortic arch.
    Title: Tentonin 3/TMEM150C senses blood pressure changes in the aortic arch.
  4. TTN3 appears to be a component of a mechanosensitive channel with a slow inactivation rate and contributes to motor coordination. Identification of this gene advances our understanding of the various types of mechanosensations, including proprioception
    Title: Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mechanosensitive monoatomic ion channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proprioception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 150C
Names
tentonin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382850.1 → NP_001369779.1  transmembrane protein 150C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124480, AC125378
    UniProtKB/Swiss-Prot
    D3YVG3, Q3TL78, Q8C8S3, Q8K117
    Conserved Domains (1) summary
    pfam10277
    Location:8 → 217
    Frag1; Frag1/DRAM/Sfk1 family

  2. NM_001382851.1 → NP_001369780.1  transmembrane protein 150C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124480, AC125378
    UniProtKB/Swiss-Prot
    D3YVG3, Q3TL78, Q8C8S3, Q8K117
    Conserved Domains (1) summary
    pfam10277
    Location:8 → 217
    Frag1; Frag1/DRAM/Sfk1 family

  3. NM_001424763.1 → NP_001411692.1  transmembrane protein 150C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124480, AC125378

  4. NM_001424764.1 → NP_001411693.1  transmembrane protein 150C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124480, AC125378

  5. NM_001424765.1 → NP_001411694.1  transmembrane protein 150C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124480, AC125378

  6. NM_001424766.1 → NP_001411695.1  transmembrane protein 150C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124480, AC125378

  7. NM_001424767.1 → NP_001411696.1  transmembrane protein 150C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124480, AC125378

  8. NM_001424768.1 → NP_001411697.1  transmembrane protein 150C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124480, AC125378

  9. NM_001424769.1 → NP_001411698.1  transmembrane protein 150C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124480, AC125378

  10. NM_001424770.1 → NP_001411699.1  transmembrane protein 150C isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC124480, AC125378

  11. NM_182841.2 → NP_878261.1  transmembrane protein 150C isoform 1

    See identical proteins and their annotated locations for NP_878261.1

    Status: VALIDATED

    Source sequence(s)
    AC124480, AC125378
    Consensus CDS
    CCDS19461.1
    UniProtKB/Swiss-Prot
    D3YVG3, Q3TL78, Q8C8S3, Q8K117
    Related
    ENSMUSP00000057116.9, ENSMUST00000063192.15
    Conserved Domains (1) summary
    pfam10277
    Location:8 → 217
    Frag1; Frag1/DRAM/Sfk1 family

RNA

  1. NR_188912.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124480, AC125378

  2. NR_188913.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124480, AC125378

  3. NR_188914.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124480, AC125378

  4. NR_188915.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124480, AC125378

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    100225731..100313463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534877.3 → XP_006534940.1  transmembrane protein 150C isoform X1

    See identical proteins and their annotated locations for XP_006534940.1

    UniProtKB/Swiss-Prot
    D3YVG3, Q3TL78, Q8C8S3, Q8K117
    Conserved Domains (1) summary
    pfam10277
    Location:8 → 217
    Frag1; Frag1/DRAM/Sfk1 family

  2. XM_036165069.1 → XP_036020962.1  transmembrane protein 150C isoform X1

    UniProtKB/Swiss-Prot
    D3YVG3, Q3TL78, Q8C8S3, Q8K117
    Conserved Domains (1) summary
    pfam10277
    Location:8 → 217
    Frag1; Frag1/DRAM/Sfk1 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C8S3.1 GenPept UniProtKB/Swiss-Prot:Q8C8S3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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