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Mat2a methionine adenosyltransferase 2A [ Mus musculus (house mouse) ]

Gene ID: 232087, updated on 9-Dec-2024

Summary

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Official Symbol
Mat2aprovided by MGI
Official Full Name
methionine adenosyltransferase 2Aprovided by MGI
Primary source
MGI:MGI:2443731
See related
Ensembl:ENSMUSG00000053907 AllianceGenome:MGI:2443731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MAT 2; D630045P18Rik
Summary
Enables methionine adenosyltransferase activity. Acts upstream of or within S-adenosylmethionine biosynthetic process and cellular response to leukemia inhibitory factor. Predicted to be part of methionine adenosyltransferase complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; eye; liver and biliary system; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human MAT2A (methionine adenosyltransferase 2A). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 103.5), whole brain E14.5 (RPKM 90.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Mat2a in Genome Data Viewer
Location:
6 C1; 6 32.27 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72409779..72416539, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72432796..72439556, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10385 Neighboring gene vesicle-associated membrane protein 8 Neighboring gene STARR-positive B cell enhancer ABC_E2789 Neighboring gene gamma-glutamyl carboxylase Neighboring gene STARR-positive B cell enhancer ABC_E6440 Neighboring gene promoter of Mat2a antisense radiation induced circulating long non-coding RNA Neighboring gene STARR-seq mESC enhancer starr_16285 Neighboring gene STARR-seq mESC enhancer starr_16286 Neighboring gene STARR-seq mESC enhancer starr_16287 Neighboring gene SH2 domain containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E11320 Neighboring gene STARR-seq mESC enhancer starr_16289 Neighboring gene STARR-positive B cell enhancer ABC_E6442 Neighboring gene capping actin protein, gelsolin like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome. Golbourn BJ, et al. Nat Cancer, 2022 May. PMID 35422502, Free PMC Article
  2. Inhibition of MAT2A suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss. Kang H, et al. FASEB J, 2022 Feb. PMID 35064691
  3. Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation. Ramani K, et al. Hepatology, 2010 Mar. PMID 20043323, Free PMC Article
  4. Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Chen H, et al. Gastroenterology, 2007 Jul. PMID 17631143
  5. Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma. Pascale RM, et al. Medicina (Kaunas), 2019 Jun 21. PMID 31234428, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA.
    Title: Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA.
  2. Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome.
    Title: Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome.
  3. Inhibition of MAT2A suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss.
    Title: Inhibition of MAT2A suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss.
  4. The reproduction of these changes in MAT1A-KO mice, prone to develop hepatitis and HCC, demonstrates the pathogenetic role of MAT1A gene under-regulation associated with up-regulation of the MAT2A gene (MAT1A:MAT2A switch), encoding the SAM synthesizing enzymes, methyladenosyltransferase I/III (MATI/III) and methyladenosyltransferase II (MATII), respectively. This leads to a rise of MATII, inhibited by the reaction produc
    Title: Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.
  5. The simultaneous downregulation of MAT1A and upregulation of MAT2A are necessary and sufficient for hepatocellular carcinoma metastasis in the process of M1-M2 switch.
    Title: A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.
  6. SIRT1 knock-out embryos display reduced Mat2a expression and histone methylation and are sensitive to maternal methionine restriction-induced lethality, whereas maternal methionine supplementation increases the survival of SIRT1 knock-out newborn mice.
    Title: Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.
  7. P300 acetylates MAT IIalpha at lysine residue 81 and destabilizes MAT IIalpha by promoting its ubiquitylation and subsequent proteasomal degradation.
    Title: Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer.
  8. MATIIalpha represses the expression of cyclooxygenase 2 (COX-2), encoded by Ptgs2, by specifically interacting with histone H3K9 methyltransferase SETDB1.
    Title: Methionine adenosyltransferase II-dependent histone H3K9 methylation at the COX-2 gene locus.
  9. Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein
    Title: Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein.
  10. MAT2A and MAT2beta genes are induced during hepatic stellate cell activation
    Title: Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6545

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methionine adenosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methionine adenosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methionine adenosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in S-adenosylmethionine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within S-adenosylmethionine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in S-adenosylmethionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in S-adenosylmethionine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to methionine IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to methionine ISO
Inferred from Sequence Orthology
more info
  
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of TORC1 signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein heterooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein hexamerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein hexamerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to cAMP ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of methionine adenosyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of methionine adenosyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of methionine adenosyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
S-adenosylmethionine synthase isoform type-2
Names
adoMet synthase 2
adoMet synthetase 2
methionine adenosyltransferase 2
methionine adenosyltransferase II, alpha
NP_001350727.1
NP_001350728.1
NP_663544.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363798.1 → NP_001350727.1  S-adenosylmethionine synthase isoform type-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK160869, BC058360
    Consensus CDS
    CCDS90059.1
    UniProtKB/TrEMBL
    A0A0U1RNT6, Q3TSS0
    Related
    ENSMUSP00000145696.2, ENSMUST00000205335.2
    Conserved Domains (1) summary
    cl27369
    Location:16 → 362
    S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

  2. NM_001363799.1 → NP_001350728.1  S-adenosylmethionine synthase isoform type-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK133960, BC058360
    Consensus CDS
    CCDS90060.1
    UniProtKB/TrEMBL
    A0A0U1RNK6, Q3UZA2
    Related
    ENSMUSP00000145603.2, ENSMUST00000206692.2
    Conserved Domains (1) summary
    cl27369
    Location:16 → 364
    S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

  3. NM_145569.5 → NP_663544.1  S-adenosylmethionine synthase isoform type-2 isoform 1

    See identical proteins and their annotated locations for NP_663544.1

    Status: VALIDATED

    Source sequence(s)
    AC116115
    Consensus CDS
    CCDS39515.1
    UniProtKB/Swiss-Prot
    Q3THS6, Q3TL60, Q76LX3
    UniProtKB/TrEMBL
    Q3TED1, Q99J57
    Related
    ENSMUSP00000087118.7, ENSMUST00000059472.10
    Conserved Domains (1) summary
    PTZ00104
    Location:16 → 395
    PTZ00104; S-adenosylmethionine synthase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    72409779..72416539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3THS6.2 GenPept UniProtKB/Swiss-Prot:Q3THS6

Gene LinkOut

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