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FLT3LG fms related receptor tyrosine kinase 3 ligand [ Homo sapiens (human) ]

Gene ID: 2323, updated on 28-Oct-2024

Summary

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Official Symbol
FLT3LGprovided by HGNC
Official Full Name
fms related receptor tyrosine kinase 3 ligandprovided by HGNC
Primary source
HGNC:HGNC:3766
See related
Ensembl:ENSG00000090554 MIM:600007; AllianceGenome:HGNC:3766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FL; FLG3L; FLT3L; IMD125
Summary
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]
Expression
Ubiquitous expression in spleen (RPKM 4.5), lymph node (RPKM 4.2) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See FLT3LG in Genome Data Viewer
Location:
19q13.33
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49474215..49486231)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52474188..52486197)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49977472..49989488)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10915 Neighboring gene PIH1 domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49954699-49955377 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:49957075-49958034 Neighboring gene aldehyde dehydrogenase 16 family member A1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14941 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10917 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14943 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49990841-49991445 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49993864-49994467 Neighboring gene ribosomal protein L13a Neighboring gene small nucleolar RNA, C/D box 32A Neighboring gene small nucleolar RNA, C/D box 33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Serum Levels of Soluble FLT3 Ligand in Patients with Active Multiple Myeloma Constitute Marker of Bone Marrow Plasma Cell Proliferative Activity. Kokonozaki M, et al. Crit Rev Oncog, 2017. PMID 29604902
  2. Cell-surface trafficking and release of flt3 ligand from T lymphocytes is induced by common cytokine receptor gamma-chain signaling and inhibited by cyclosporin A. Chklovskaia E, et al. Blood, 2001 Feb 15. PMID 11159533
  3. Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots. Savvides SN, et al. Nat Struct Biol, 2000 Jun. PMID 10881197
  4. Expression of Flt3-ligand by the endothelial cell. Solanilla A, et al. Leukemia, 2000 Jan. PMID 10637491
  5. Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: a principal role for flt3 ligand in lymphopoiesis. Nakamori Y, et al. Br J Haematol, 2012 Jun. PMID 22463758

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice.
    Title: FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice.
  2. Early-life hyperoxia-induced Flt3L drives neonatal lung dendritic cell expansion and proinflammatory responses.
    Title: Early-life hyperoxia-induced Flt3L drives neonatal lung dendritic cell expansion and proinflammatory responses.
  3. FLT3LG and IFITM3P6 consolidate T cell activity in the bone marrow microenvironment and are prognostic factors in acute myelocytic leukemia.
    Title: FLT3LG and IFITM3P6 consolidate T cell activity in the bone marrow microenvironment and are prognostic factors in acute myelocytic leukemia.
  4. Fast Maturation of Splenic Dendritic Cells Upon TBI Is Associated With FLT3/FLT3L Signaling.
    Title: Fast Maturation of Splenic Dendritic Cells Upon TBI Is Associated With FLT3/FLT3L Signaling.
  5. A new cytokine-based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia.
    Title: A new cytokine-based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia.
  6. Wild-type FLT3 and FLT3 ITD exhibit similar ligand-induced internalization characteristics.
    Title: Wild-type FLT3 and FLT3 ITD exhibit similar ligand-induced internalization characteristics.
  7. FLT3 ligand plasma levels have no impact on outcomes after allotransplant in acute leukemia.
    Title: FLT3 ligand plasma levels have no impact on outcomes after allotransplant in acute leukemia.
  8. the sFLc kinetic profile during induction appears to be a powerful early prognostic marker to take into account as it may help to classify AML patients better
    Title: FLT3 ligand plasma levels in acute myeloid leukemia.
  9. This study provides a platform for studying the in vivo effect of Flt3-L and GM-CSF on human DCs and regulatory T cells.
    Title: Introduction of Human Flt3-L and GM-CSF into Humanized Mice Enhances the Reconstitution and Maturation of Myeloid Dendritic Cells and the Development of Foxp3(+)CD4(+) T Cells.
  10. In both cohorts, the median Flt3L level was significantly higher at completion of each sequential modality than at baseline. The 5-year PFS (most events being metastatic progression) was 68% and 71% in the two cohorts consisting of 33% and 52% T4 cases. In the principal cohort, a high Flt3L level following the induction chemotherapy was associated with low risk for a PFS event (HR: 0.15; P < 0.01).
    Title: Systemic immune response induced by oxaliplatin-based neoadjuvant therapy favours survival without metastatic progression in high-risk rectal cancer.
Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryonic hemopoiesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fms-related tyrosine kinase 3 ligand
Names
flt3 ligand
fms related tyrosine kinase 3 ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204502.2 → NP_001191431.1  fms-related tyrosine kinase 3 ligand isoform 1 precursor

    See identical proteins and their annotated locations for NP_001191431.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    BC006331, BC144129, DB490139, U03858
    Consensus CDS
    CCDS12767.1
    UniProtKB/Swiss-Prot
    A0AVC2, B9EGH2, P49771, Q05C96
    UniProtKB/TrEMBL
    B7ZLY4
    Related
    ENSP00000470453.1, ENST00000600429.5
    Conserved Domains (1) summary
    pfam02947
    Location:29 → 159
    Flt3_lig; flt3 ligand

  2. NM_001204503.2 → NP_001191432.1  fms-related tyrosine kinase 3 ligand isoform 1 precursor

    See identical proteins and their annotated locations for NP_001191432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    BC006331, U03858
    Consensus CDS
    CCDS12767.1
    UniProtKB/Swiss-Prot
    A0AVC2, B9EGH2, P49771, Q05C96
    UniProtKB/TrEMBL
    B7ZLY4
    Related
    ENSP00000469613.1, ENST00000594009.5
    Conserved Domains (1) summary
    pfam02947
    Location:29 → 159
    Flt3_lig; flt3 ligand

  3. NM_001278637.2 → NP_001265566.1  fms-related tyrosine kinase 3 ligand isoform 2

    See identical proteins and their annotated locations for NP_001265566.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC010619, BC011914, BC028001
    Consensus CDS
    CCDS62753.1
    UniProtKB/Swiss-Prot
    P49771
    Conserved Domains (1) summary
    pfam02947
    Location:1 → 77
    Flt3_lig; flt3 ligand

  4. NM_001278638.2 → NP_001265567.1  fms-related tyrosine kinase 3 ligand isoform 2

    See identical proteins and their annotated locations for NP_001265567.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 4 and 5 encode the same isoform (2).
    Source sequence(s)
    AC010619, BC011914
    Consensus CDS
    CCDS62753.1
    UniProtKB/Swiss-Prot
    P49771
    Related
    ENSP00000204637.2, ENST00000204637.6
    Conserved Domains (1) summary
    pfam02947
    Location:1 → 77
    Flt3_lig; flt3 ligand

  5. NM_001459.4 → NP_001450.2  fms-related tyrosine kinase 3 ligand isoform 1 precursor

    See identical proteins and their annotated locations for NP_001450.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    BC006331, BC136464, DB490139
    Consensus CDS
    CCDS12767.1
    UniProtKB/Swiss-Prot
    A0AVC2, B9EGH2, P49771, Q05C96
    UniProtKB/TrEMBL
    B7ZLY4
    Related
    ENSP00000468977.1, ENST00000597551.6
    Conserved Domains (1) summary
    pfam02947
    Location:29 → 159
    Flt3_lig; flt3 ligand

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    49474215..49486231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526675.3 → XP_011524977.1  fms-related tyrosine kinase 3 ligand isoform X3

    See identical proteins and their annotated locations for XP_011524977.1

    Conserved Domains (1) summary
    pfam02947
    Location:29 → 159
    Flt3_lig; flt3 ligand

  2. XM_011526678.3 → XP_011524980.1  fms-related tyrosine kinase 3 ligand isoform X6

    See identical proteins and their annotated locations for XP_011524980.1

    UniProtKB/TrEMBL
    M0QXI0
    Related
    ENSP00000469181.1, ENST00000598555.1
    Conserved Domains (1) summary
    pfam02947
    Location:29 → 141
    Flt3_lig; flt3 ligand

  3. XM_047438522.1 → XP_047294478.1  fms-related tyrosine kinase 3 ligand isoform X8

  4. XM_047438523.1 → XP_047294479.1  fms-related tyrosine kinase 3 ligand isoform X9

  5. XM_011526676.4 → XP_011524978.1  fms-related tyrosine kinase 3 ligand isoform X3

    See identical proteins and their annotated locations for XP_011524978.1

    Conserved Domains (1) summary
    pfam02947
    Location:29 → 159
    Flt3_lig; flt3 ligand

  6. XM_047438519.1 → XP_047294475.1  fms-related tyrosine kinase 3 ligand isoform X1

  7. XM_011526677.3 → XP_011524979.1  fms-related tyrosine kinase 3 ligand isoform X5

    Conserved Domains (1) summary
    pfam02947
    Location:29 → 159
    Flt3_lig; flt3 ligand

  8. XM_047438521.1 → XP_047294477.1  fms-related tyrosine kinase 3 ligand isoform X7

  9. XM_011526680.3 → XP_011524982.1  fms-related tyrosine kinase 3 ligand isoform X10

    Conserved Domains (1) summary
    pfam02947
    Location:29 → 114
    Flt3_lig; flt3 ligand

  10. XM_006723116.4 → XP_006723179.2  fms-related tyrosine kinase 3 ligand isoform X4

    See identical proteins and their annotated locations for XP_006723179.2

    Conserved Domains (1) summary
    pfam02947
    Location:29 → 119
    Flt3_lig; flt3 ligand

  11. XM_047438520.1 → XP_047294476.1  fms-related tyrosine kinase 3 ligand isoform X2

    UniProtKB/Swiss-Prot
    A0AVC2, B9EGH2, P49771, Q05C96

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    52474188..52486197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320359.1 → XP_054176334.1  fms-related tyrosine kinase 3 ligand isoform X3

  2. XM_054320363.1 → XP_054176338.1  fms-related tyrosine kinase 3 ligand isoform X6

  3. XM_054320365.1 → XP_054176340.1  fms-related tyrosine kinase 3 ligand isoform X8

  4. XM_054320366.1 → XP_054176341.1  fms-related tyrosine kinase 3 ligand isoform X9

  5. XM_054320360.1 → XP_054176335.1  fms-related tyrosine kinase 3 ligand isoform X3

  6. XM_054320357.1 → XP_054176332.1  fms-related tyrosine kinase 3 ligand isoform X1

  7. XM_054320362.1 → XP_054176337.1  fms-related tyrosine kinase 3 ligand isoform X5

  8. XM_054320364.1 → XP_054176339.1  fms-related tyrosine kinase 3 ligand isoform X7

  9. XM_054320367.1 → XP_054176342.1  fms-related tyrosine kinase 3 ligand isoform X10

  10. XM_054320361.1 → XP_054176336.1  fms-related tyrosine kinase 3 ligand isoform X4

  11. XM_054320358.1 → XP_054176333.1  fms-related tyrosine kinase 3 ligand isoform X2

    UniProtKB/Swiss-Prot
    A0AVC2, B9EGH2, P49771, Q05C96
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49771.1 GenPept UniProtKB/Swiss-Prot:P49771

Gene LinkOut

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