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TMEM131L transmembrane 131 like [ Homo sapiens (human) ]

Gene ID: 23240, updated on 17-Jun-2024

Summary

Official Symbol
TMEM131Lprovided by HGNC
Official Full Name
transmembrane 131 likeprovided by HGNC
Primary source
HGNC:HGNC:29146
See related
Ensembl:ENSG00000121210 MIM:616243; AllianceGenome:HGNC:29146
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA0922
Summary
Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of immature T cell proliferation in thymus. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lymph node (RPKM 22.3), bone marrow (RPKM 15.4) and 22 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See TMEM131L in Genome Data Viewer
Location:
4q31.3
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (153466360..153636711)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (156790800..156961149)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (154387512..154557863)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22052 Neighboring gene annexin A2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 419, pseudogene Neighboring gene meiotic nuclear divisions 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15762 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154388523-154389188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154390454-154390954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154390955-154391455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154415607-154416604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22068 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:154433973-154434472 Neighboring gene NANOG hESC enhancer GRCh37_chr4:154442146-154442647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22069 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:154444154-154444994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15763 Neighboring gene uncharacterized LOC105377498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154455569-154456145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154456146-154456721 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:154457236-154457741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15764 Neighboring gene toll like receptor 2 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154561385-154561884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15767 Neighboring gene WD repeat domain 45 pseudogene 1 Neighboring gene toll like receptor 2 Neighboring gene ring finger protein 175

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of KIAA0922 by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with KIAA0922 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ10592, DKFZp586H1322

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transmembrane protein 131-like

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131007.2NP_001124479.1  transmembrane protein 131-like isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AK092270, AK096538, AK308448, BC044932
    Consensus CDS
    CCDS47148.1
    UniProtKB/TrEMBL
    H0Y2M0
    Related
    ENSP00000386787.3, ENST00000409959.8
    Conserved Domains (1) summary
    cl13764
    Location:91174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  2. NM_015196.4NP_056011.3  transmembrane protein 131-like isoform 2 precursor

    See identical proteins and their annotated locations for NP_056011.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the mid coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    BC131505, BQ270562, DA778851
    Consensus CDS
    CCDS3783.2
    UniProtKB/Swiss-Prot
    A2VDJ0, B3KRV3, D3DP10, Q7LGA7, Q86Y92, Q8WU56, Q9H065, Q9Y2D7
    UniProtKB/TrEMBL
    H0Y2M0
    Related
    ENSP00000386574.3, ENST00000409663.7
    Conserved Domains (2) summary
    pfam19532
    Location:1851609
    TMEM131_like; Transmembrane protein 131-like
    cl13764
    Location:91174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    153466360..153636711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449899.1XP_047305855.1  transmembrane protein 131-like isoform X1

    UniProtKB/TrEMBL
    H0Y2M0
  2. XM_011531780.2XP_011530082.1  transmembrane protein 131-like isoform X4

    UniProtKB/TrEMBL
    H0Y2M0
    Conserved Domains (1) summary
    cl13764
    Location:120203
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  3. XM_047449901.1XP_047305857.1  transmembrane protein 131-like isoform X3

    UniProtKB/TrEMBL
    H0Y2M0
  4. XM_047449902.1XP_047305858.1  transmembrane protein 131-like isoform X6

    UniProtKB/TrEMBL
    H0Y2M0
  5. XM_047449917.1XP_047305873.1  transmembrane protein 131-like isoform X25

    UniProtKB/TrEMBL
    H0Y2M0
  6. XM_011531783.2XP_011530085.1  transmembrane protein 131-like isoform X28

    UniProtKB/TrEMBL
    H0Y2M0
    Conserved Domains (1) summary
    cl13764
    Location:120203
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  7. XM_047449920.1XP_047305876.1  transmembrane protein 131-like isoform X29

    UniProtKB/TrEMBL
    H0Y2M0
  8. XM_047449900.1XP_047305856.1  transmembrane protein 131-like isoform X2

    UniProtKB/TrEMBL
    H0Y2M0
  9. XM_011531781.2XP_011530083.1  transmembrane protein 131-like isoform X5

    UniProtKB/TrEMBL
    H0Y2M0
    Conserved Domains (1) summary
    cl13764
    Location:120203
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  10. XM_047449903.1XP_047305859.1  transmembrane protein 131-like isoform X7

    UniProtKB/TrEMBL
    H0Y2M0
  11. XM_047449918.1XP_047305874.1  transmembrane protein 131-like isoform X26

    UniProtKB/TrEMBL
    H0Y2M0
  12. XM_047449919.1XP_047305875.1  transmembrane protein 131-like isoform X27

    UniProtKB/TrEMBL
    H0Y2M0
  13. XM_047449904.1XP_047305860.1  transmembrane protein 131-like isoform X8

    UniProtKB/TrEMBL
    H0Y2M0
  14. XM_047449908.1XP_047305864.1  transmembrane protein 131-like isoform X14

    UniProtKB/TrEMBL
    H0Y2M0
  15. XM_047449909.1XP_047305865.1  transmembrane protein 131-like isoform X15

    UniProtKB/TrEMBL
    H0Y2M0
  16. XM_047449905.1XP_047305861.1  transmembrane protein 131-like isoform X9

    UniProtKB/TrEMBL
    H0Y2M0
  17. XM_047449910.1XP_047305866.1  transmembrane protein 131-like isoform X16

    UniProtKB/TrEMBL
    H0Y2M0
  18. XM_024453956.2XP_024309724.1  transmembrane protein 131-like isoform X10

    UniProtKB/TrEMBL
    H0Y2M0
    Conserved Domains (1) summary
    cl13764
    Location:91174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  19. XM_047449906.1XP_047305862.1  transmembrane protein 131-like isoform X11

    UniProtKB/TrEMBL
    H0Y2M0
  20. XM_017007925.2XP_016863414.1  transmembrane protein 131-like isoform X17

    UniProtKB/TrEMBL
    H0Y2M0
  21. XM_047449921.1XP_047305877.1  transmembrane protein 131-like isoform X30

    UniProtKB/TrEMBL
    H0Y2M0
  22. XM_047449923.1XP_047305879.1  transmembrane protein 131-like isoform X32

    UniProtKB/TrEMBL
    H0Y2M0
    Related
    ENSP00000240487.5, ENST00000240487.5
  23. XM_047449925.1XP_047305881.1  transmembrane protein 131-like isoform X34

    UniProtKB/TrEMBL
    H0Y2M0
  24. XM_024453957.2XP_024309725.1  transmembrane protein 131-like isoform X12

    UniProtKB/TrEMBL
    H0Y2M0
    Conserved Domains (1) summary
    cl13764
    Location:91174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  25. XM_047449907.1XP_047305863.1  transmembrane protein 131-like isoform X13

    UniProtKB/TrEMBL
    H0Y2M0
  26. XM_017007926.2XP_016863415.1  transmembrane protein 131-like isoform X18

    UniProtKB/TrEMBL
    H0Y2M0
  27. XM_047449922.1XP_047305878.1  transmembrane protein 131-like isoform X31

    UniProtKB/TrEMBL
    H0Y2M0
  28. XM_047449924.1XP_047305880.1  transmembrane protein 131-like isoform X33

    UniProtKB/TrEMBL
    H0Y2M0
  29. XM_047449926.1XP_047305882.1  transmembrane protein 131-like isoform X35

    UniProtKB/TrEMBL
    H0Y2M0
  30. XM_047449911.1XP_047305867.1  transmembrane protein 131-like isoform X19

    UniProtKB/TrEMBL
    H0Y2M0
  31. XM_047449913.1XP_047305869.1  transmembrane protein 131-like isoform X21

    UniProtKB/TrEMBL
    H0Y2M0
  32. XM_047449915.1XP_047305871.1  transmembrane protein 131-like isoform X23

    UniProtKB/TrEMBL
    H0Y2M0
  33. XM_047449927.1XP_047305883.1  transmembrane protein 131-like isoform X36

    UniProtKB/TrEMBL
    H0Y2M0
  34. XM_047449912.1XP_047305868.1  transmembrane protein 131-like isoform X20

    UniProtKB/TrEMBL
    H0Y2M0
  35. XM_047449914.1XP_047305870.1  transmembrane protein 131-like isoform X22

    UniProtKB/TrEMBL
    H0Y2M0
  36. XM_047449916.1XP_047305872.1  transmembrane protein 131-like isoform X24

    UniProtKB/TrEMBL
    H0Y2M0
  37. XM_047449928.1XP_047305884.1  transmembrane protein 131-like isoform X37

    UniProtKB/TrEMBL
    H0Y2M0
  38. XM_047449929.1XP_047305885.1  transmembrane protein 131-like isoform X38

    UniProtKB/TrEMBL
    H0Y2M0
  39. XM_047449930.1XP_047305886.1  transmembrane protein 131-like isoform X39

    UniProtKB/TrEMBL
    H0Y2M0
  40. XM_024453958.2XP_024309726.1  transmembrane protein 131-like isoform X40

    UniProtKB/TrEMBL
    B3KU55

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    156790800..156961149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349416.1XP_054205391.1  transmembrane protein 131-like isoform X1

    UniProtKB/TrEMBL
    H0Y2M0
  2. XM_054349419.1XP_054205394.1  transmembrane protein 131-like isoform X4

    UniProtKB/TrEMBL
    H0Y2M0
  3. XM_054349425.1XP_054205400.1  transmembrane protein 131-like isoform X10

    UniProtKB/TrEMBL
    H0Y2M0
  4. XM_054349426.1XP_054205401.1  transmembrane protein 131-like isoform X11

    UniProtKB/TrEMBL
    H0Y2M0
  5. XM_054349432.1XP_054205407.1  transmembrane protein 131-like isoform X17

    UniProtKB/TrEMBL
    H0Y2M0
  6. XM_054349445.1XP_054205420.1  transmembrane protein 131-like isoform X30

    UniProtKB/TrEMBL
    H0Y2M0
  7. XM_054349447.1XP_054205422.1  transmembrane protein 131-like isoform X32

    UniProtKB/TrEMBL
    H0Y2M0
  8. XM_054349449.1XP_054205424.1  transmembrane protein 131-like isoform X34

    UniProtKB/TrEMBL
    H0Y2M0
  9. XM_054349427.1XP_054205402.1  transmembrane protein 131-like isoform X12

    UniProtKB/TrEMBL
    H0Y2M0
  10. XM_054349428.1XP_054205403.1  transmembrane protein 131-like isoform X13

    UniProtKB/TrEMBL
    H0Y2M0
  11. XM_054349433.1XP_054205408.1  transmembrane protein 131-like isoform X18

    UniProtKB/TrEMBL
    H0Y2M0
  12. XM_054349446.1XP_054205421.1  transmembrane protein 131-like isoform X31

    UniProtKB/TrEMBL
    H0Y2M0
  13. XM_054349448.1XP_054205423.1  transmembrane protein 131-like isoform X33

    UniProtKB/TrEMBL
    H0Y2M0
  14. XM_054349450.1XP_054205425.1  transmembrane protein 131-like isoform X35

    UniProtKB/TrEMBL
    H0Y2M0
  15. XM_054349434.1XP_054205409.1  transmembrane protein 131-like isoform X19

    UniProtKB/TrEMBL
    H0Y2M0
  16. XM_054349436.1XP_054205411.1  transmembrane protein 131-like isoform X21

    UniProtKB/TrEMBL
    H0Y2M0
  17. XM_054349438.1XP_054205413.1  transmembrane protein 131-like isoform X23

    UniProtKB/TrEMBL
    H0Y2M0
  18. XM_054349451.1XP_054205426.1  transmembrane protein 131-like isoform X36

    UniProtKB/TrEMBL
    H0Y2M0
  19. XM_054349435.1XP_054205410.1  transmembrane protein 131-like isoform X20

    UniProtKB/TrEMBL
    H0Y2M0
  20. XM_054349437.1XP_054205412.1  transmembrane protein 131-like isoform X22

    UniProtKB/TrEMBL
    H0Y2M0
  21. XM_054349439.1XP_054205414.1  transmembrane protein 131-like isoform X24

    UniProtKB/TrEMBL
    H0Y2M0
  22. XM_054349452.1XP_054205427.1  transmembrane protein 131-like isoform X37

    UniProtKB/TrEMBL
    H0Y2M0
  23. XM_054349418.1XP_054205393.1  transmembrane protein 131-like isoform X3

    UniProtKB/TrEMBL
    H0Y2M0
  24. XM_054349421.1XP_054205396.1  transmembrane protein 131-like isoform X6

    UniProtKB/TrEMBL
    H0Y2M0
  25. XM_054349453.1XP_054205428.1  transmembrane protein 131-like isoform X38

    UniProtKB/TrEMBL
    H0Y2M0
  26. XM_054349454.1XP_054205429.1  transmembrane protein 131-like isoform X39

    UniProtKB/TrEMBL
    H0Y2M0
  27. XM_054349440.1XP_054205415.1  transmembrane protein 131-like isoform X25

    UniProtKB/TrEMBL
    H0Y2M0
  28. XM_054349443.1XP_054205418.1  transmembrane protein 131-like isoform X28

    UniProtKB/TrEMBL
    H0Y2M0
  29. XM_054349444.1XP_054205419.1  transmembrane protein 131-like isoform X29

    UniProtKB/TrEMBL
    H0Y2M0
  30. XM_054349420.1XP_054205395.1  transmembrane protein 131-like isoform X5

    UniProtKB/TrEMBL
    H0Y2M0
  31. XM_054349417.1XP_054205392.1  transmembrane protein 131-like isoform X2

    UniProtKB/TrEMBL
    H0Y2M0
  32. XM_054349422.1XP_054205397.1  transmembrane protein 131-like isoform X7

    UniProtKB/TrEMBL
    H0Y2M0
  33. XM_054349441.1XP_054205416.1  transmembrane protein 131-like isoform X26

    UniProtKB/TrEMBL
    H0Y2M0
  34. XM_054349442.1XP_054205417.1  transmembrane protein 131-like isoform X27

    UniProtKB/TrEMBL
    H0Y2M0
  35. XM_054349423.1XP_054205398.1  transmembrane protein 131-like isoform X8

    UniProtKB/TrEMBL
    H0Y2M0
  36. XM_054349429.1XP_054205404.1  transmembrane protein 131-like isoform X14

    UniProtKB/TrEMBL
    H0Y2M0
  37. XM_054349430.1XP_054205405.1  transmembrane protein 131-like isoform X15

    UniProtKB/TrEMBL
    H0Y2M0
  38. XM_054349424.1XP_054205399.1  transmembrane protein 131-like isoform X9

    UniProtKB/TrEMBL
    H0Y2M0
  39. XM_054349431.1XP_054205406.1  transmembrane protein 131-like isoform X16

    UniProtKB/TrEMBL
    H0Y2M0
  40. XM_054349455.1XP_054205430.1  transmembrane protein 131-like isoform X41

    UniProtKB/TrEMBL
    B3KU55