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Crebl2 cAMP responsive element binding protein-like 2 [ Mus musculus (house mouse) ]

Gene ID: 232430, updated on 2-Nov-2024

Summary

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Official Symbol
Crebl2provided by MGI
Official Full Name
cAMP responsive element binding protein-like 2provided by MGI
Primary source
MGI:MGI:1889385
See related
Ensembl:ENSMUSG00000032652 AllianceGenome:MGI:1889385
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B230205M03
Summary
Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including positive regulation of D-glucose import; positive regulation of macromolecule metabolic process; and protein stabilization. Located in nucleus. Orthologous to human CREBL2 (cAMP responsive element binding protein like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 5.4), cerebellum adult (RPKM 4.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Crebl2 in Genome Data Viewer
Location:
6 G1; 6 65.77 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (134807090..134835894)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (134830127..134880580)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 16 Neighboring gene STARR-seq mESC enhancer starr_17547 Neighboring gene predicted gene, 36328 Neighboring gene RIKEN cDNA 1700055D16 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:134742531-134742832 Neighboring gene STARR-positive B cell enhancer ABC_E3688 Neighboring gene predicted gene, 53343 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:134779903-134780086 Neighboring gene G protein-coupled receptor 19 Neighboring gene RIKEN cDNA 2810454H06 gene Neighboring gene CRISPRi-validated cis-regulatory element for Cdkn1b and Gpr19 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:134848417-134848526 Neighboring gene predicted gene, 53344

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Parathyroid hormone receptor-1 signaling aggravates hepatic fibrosis through upregulating cAMP response element-binding protein-like 2. Hong T, et al. Hepatology, 2023 Dec 1. PMID 36939197
  2. CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes. Ma X, et al. Biochem J, 2011 Oct 1. PMID 21728997
  3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Parathyroid hormone receptor-1 signaling aggravates hepatic fibrosis through upregulating cAMP response element-binding protein-like 2.
    Title: Parathyroid hormone receptor-1 signaling aggravates hepatic fibrosis through upregulating cAMP response element-binding protein-like 2.
  2. Results of the present study indicate that CREBL2 plays a critical role in adipogenesis and lipogenesis via interaction with CREB.
    Title: CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Clone Names

  • MGC130380, MGC130381

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of D-glucose import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cAMP-responsive element-binding protein-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177687.3 → NP_808355.1  cAMP-responsive element-binding protein-like 2

    See identical proteins and their annotated locations for NP_808355.1

    Status: PROVISIONAL

    Source sequence(s)
    AK045467
    Consensus CDS
    CCDS20640.1
    UniProtKB/TrEMBL
    A0A0R4J0D8
    Related
    ENSMUSP00000035304.6, ENSMUST00000046303.12
    Conserved Domains (1) summary
    cd14709
    Location:25 → 80
    bZIP_CREBL2; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 (CREBL2): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    134807090..134835894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241329.4 → XP_011239631.2  cAMP-responsive element-binding protein-like 2 isoform X1

    UniProtKB/TrEMBL
    A0A0R4J0D8
    Conserved Domains (1) summary
    cd14709
    Location:25 → 80
    bZIP_CREBL2; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 (CREBL2): a DNA-binding and dimerization domain

  2. XM_036166087.1 → XP_036021980.1  cAMP-responsive element-binding protein-like 2 isoform X2

    Conserved Domains (1) summary
    cd14709
    Location:21 → 76
    bZIP_CREBL2; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 (CREBL2): a DNA-binding and dimerization domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32M00.1 GenPept UniProtKB/Swiss-Prot:Q32M00

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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