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Galnt18 polypeptide N-acetylgalactosaminyltransferase 18 [ Mus musculus (house mouse) ]

Gene ID: 233733, updated on 12-May-2024

Summary

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Official Symbol
Galnt18provided by MGI
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 18provided by MGI
Primary source
MGI:MGI:2446239
See related
Ensembl:ENSMUSG00000038296 AllianceGenome:MGI:2446239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Galntl4; galNAc-T18; 2900011G21Rik; mpp-GalNAc-T18(O18)
Summary
Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; cranium; respiratory system; and sensory organ. Orthologous to human GALNT18 (polypeptide N-acetylgalactosaminyltransferase 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 56.9), genital fat pad adult (RPKM 13.8) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Galnt18 in Genome Data Viewer
Location:
7 E3- F1; 7 58.19 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (111070863..111379274, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (111471656..111780067, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19844 Neighboring gene predicted gene, 33145 Neighboring gene STARR-seq mESC enhancer starr_19845 Neighboring gene STARR-seq mESC enhancer starr_19846 Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_19847 Neighboring gene STARR-seq mESC enhancer starr_19848 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene predicted gene, 23345

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The role of mucin-type O-glycans in eukaryotic development. Tabak LA. Semin Cell Dev Biol, 2010 Aug. PMID 20144722, Free PMC Article
  2. Recent insights into the biological roles of mucin-type O-glycosylation. Tian E, et al. Glycoconj J, 2009 Apr. PMID 18695988, Free PMC Article
  3. UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree. Raman J, et al. Glycobiology, 2012 Jun. PMID 22186971, Free PMC Article
  4. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31740596, Free PMC Article
  5. Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. Peluso G, et al. J Biol Chem, 2020 Jan 31. PMID 31882545, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC32465

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 18
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 4
galNAc-T-like protein 4
polypeptide GalNAc transferase 18
polypeptide GalNAc transferase-like protein 4
pp-GaNTase-like protein 4
protein-UDP acetylgalactosaminyltransferase-like protein 4
NP_001347832.1
NP_776100.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360903.1 → NP_001347832.1  polypeptide N-acetylgalactosaminyltransferase 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB175685, AC138151, AC139943, AW124105
    Consensus CDS
    CCDS90311.1
    UniProtKB/TrEMBL
    Q59J91
    Related
    ENSMUSP00000102274.2, ENSMUST00000106663.2
    Conserved Domains (2) summary
    cd02510
    Location:157 → 458
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:471 → 598
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

  2. NM_173739.4 → NP_776100.2  polypeptide N-acetylgalactosaminyltransferase 18 isoform 1

    See identical proteins and their annotated locations for NP_776100.2

    Status: VALIDATED

    Source sequence(s)
    AA611977, AC132425, AC138151, AC139943, AW124105, BM948475, BQ830603
    Consensus CDS
    CCDS21751.1
    UniProtKB/Swiss-Prot
    Q8K1B9
    Related
    ENSMUSP00000043636.9, ENSMUST00000049430.15
    Conserved Domains (3) summary
    cd02510
    Location:157 → 473
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:486 → 613
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:484 → 611
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    111070863..111379274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003946460.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1B9.1 GenPept UniProtKB/Swiss-Prot:Q8K1B9

Gene LinkOut

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