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Tufm Tu translation elongation factor, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 233870, updated on 27-Nov-2024

Summary

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Official Symbol
Tufmprovided by MGI
Official Full Name
Tu translation elongation factor, mitochondrialprovided by MGI
Primary source
MGI:MGI:1923686
See related
Ensembl:ENSMUSG00000073838 AllianceGenome:MGI:1923686
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EFTU; EF-TuMT; 2300002G02Rik
Summary
Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Located in mitochondrial inner membrane and myelin sheath. Is expressed in embryo. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 4. Orthologous to human TUFM (Tu translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 104.1), heart adult (RPKM 88.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tufm in Genome Data Viewer
Location:
7 F3; 7 69.08 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126086445..126089903)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126487271..126490731)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133618829-133619012 Neighboring gene SH2B adaptor protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E4975 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133630590-133630777 Neighboring gene predicted gene, 46001 Neighboring gene ataxin 2-like Neighboring gene RIKEN cDNA 4930456A14 gene Neighboring gene STARR-positive B cell enhancer ABC_E555 Neighboring gene STARR-positive B cell enhancer ABC_E10474 Neighboring gene STARR-positive B cell enhancer ABC_E8209 Neighboring gene STARR-seq mESC enhancer starr_20151 Neighboring gene eukaryotic translation initiation factor 3, subunit C Neighboring gene predicted gene, 24596

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Activation of mitochondrial TUFM ameliorates metabolic dysregulation through coordinating autophagy induction. Kim D, et al. Commun Biol, 2021 Jan 4. PMID 33398033, Free PMC Article
  2. FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM. Bi Y, et al. Cell Death Dis, 2022 Dec 5. PMID 36470869, Free PMC Article
  3. TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS. Zhong BR, et al. FASEB J, 2021 May. PMID 33774866
  4. Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation. Chatla S, et al. Stem Cell Res, 2019 Oct. PMID 31472450, Free PMC Article
  5. The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Lei Y, et al. Immunity, 2012 Jun 29. PMID 22749352, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM.
    Title: FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM.
  2. TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS.
    Title: TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS.
  3. Activation of mitochondrial TUFM ameliorates metabolic dysregulation through coordinating autophagy induction.
    Title: Activation of mitochondrial TUFM ameliorates metabolic dysregulation through coordinating autophagy induction.
  4. Fancd2 localizes in the mitochondrion and associates with the nucleoid complex components Atad3 and Tufm.
    Title: Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
  5. By recruiting Atg5-Atg12 and NLRX1, TUFM serves as a nodal checkpoint of the RIG-I-MAVS axis. It acts similarly to NLRX1 by inhibiting RigI-like-receptor-induced IFN-I but promoting autophagy.
    Title: The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables translation elongation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in translational elongation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial nucleoid IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in myelin sheath HDA PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
elongation factor Tu, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163713.1 → NP_001157185.1  elongation factor Tu, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001157185.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate segment that results in a frameshift compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK152858, BC060959, BU699735, BY246546
    Consensus CDS
    CCDS52398.1
    UniProtKB/Swiss-Prot
    Q8BFR5
    Related
    ENSMUSP00000102000.4, ENSMUST00000106392.10
    Conserved Domains (3) summary
    cd01884
    Location:56 → 250
    EF_Tu; Elongation Factor Tu (EF-Tu) GTP-binding proteins
    pfam00009
    Location:55 → 248
    GTP_EFTU; Elongation factor Tu GTP binding domain
    cd03697
    Location:258 → 344
    EFTU_II; Domain II of elongation factor Tu

  2. NM_172745.3 → NP_766333.1  elongation factor Tu, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_766333.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK152858, BC060959, BY246546
    Consensus CDS
    CCDS21830.1
    UniProtKB/Swiss-Prot
    Q497E7, Q6P919, Q8BFR5
    Related
    ENSMUSP00000095656.5, ENSMUST00000098048.6
    Conserved Domains (4) summary
    cd01884
    Location:56 → 250
    EF_Tu; Elongation Factor Tu (EF-Tu) GTP-binding proteins
    PRK00049
    Location:47 → 439
    PRK00049; elongation factor Tu; Reviewed
    cd03697
    Location:258 → 344
    EFTU_II; Domain II of elongation factor Tu
    cd03706
    Location:347 → 439
    mtEFTU_III; Domain III of mitochondrial EF-TU (mtEF-TU)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126086445..126089903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507719.5 → XP_006507782.1  elongation factor Tu, mitochondrial isoform X1

    Conserved Domains (1) summary
    PRK00049
    Location:47 → 411
    PRK00049; elongation factor Tu; Reviewed

  2. XM_036153012.1 → XP_036008905.1  elongation factor Tu, mitochondrial isoform X2

    Conserved Domains (1) summary
    PRK00049
    Location:1 → 303
    PRK00049; elongation factor Tu; Reviewed
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BFR5.1 GenPept UniProtKB/Swiss-Prot:Q8BFR5

Gene LinkOut

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