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Gpr26 G protein-coupled receptor 26 [ Mus musculus (house mouse) ]

Gene ID: 233919, updated on 9-Dec-2024

Summary

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Official Symbol
Gpr26provided by MGI
Official Full Name
G protein-coupled receptor 26provided by MGI
Primary source
MGI:MGI:2441758
See related
Ensembl:ENSMUSG00000040125 AllianceGenome:MGI:2441758
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A730021D22; 9630036A11Rik
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Is expressed in central nervous system. Orthologous to human GPR26 (G protein-coupled receptor 26). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in cortex adult (RPKM 6.7), frontal lobe adult (RPKM 5.3) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Gpr26 in Genome Data Viewer
Location:
7 F3; 7 75.28 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (131567891..131587362)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (131966162..131985633)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33146 Neighboring gene predicted gene, 34725 Neighboring gene STARR-seq mESC enhancer starr_20288 Neighboring gene carboxypeptidase X, M14 family member 2 Neighboring gene STARR-seq mESC enhancer starr_20291 Neighboring gene carbohydrate sulfotransferase 15 Neighboring gene STARR-positive B cell enhancer ABC_E8215 Neighboring gene predicted gene 10584

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Constitutive activity of GPR26 regulated by ubiquitin-dependent degradation and its antitumor role. Liu F, et al. FEBS J, 2021 Aug. PMID 33577134
  2. GPR26-deficient mice display increased anxiety- and depression-like behaviors accompanied by reduced phosphorylated cyclic AMP responsive element-binding protein level in central amygdala. Zhang LL, et al. Neuroscience, 2011 Nov 24. PMID 21924326
  3. Targeted inactivation of GPR26 leads to hyperphagia and adiposity by activating AMPK in the hypothalamus. Chen D, et al. PLoS One, 2012. PMID 22815809, Free PMC Article
  4. Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78. Jones PG, et al. Biochim Biophys Acta, 2007 Jun. PMID 17363172
  5. Tlx3 Exerts Direct Control in Specifying Excitatory Over Inhibitory Neurons in the Dorsal Spinal Cord. Monteiro FA, et al. Front Cell Dev Biol, 2021. PMID 33996801, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Constitutive activity of GPR26 regulated by ubiquitin-dependent degradation and its antitumor role.
    Title: Constitutive activity of GPR26 regulated by ubiquitin-dependent degradation and its antitumor role.
  2. These findings identified a key role of GPR26 as a central regulator of energy homeostasis though modulation of hypothalamic AMPK activation.
    Title: Targeted inactivation of GPR26 leads to hyperphagia and adiposity by activating AMPK in the hypothalamus.
  3. data indicate that Gpr26 is important for emotion regulation in mice, a function probably mediated by the phosphorylation of CREB in the central amygdala.
    Title: GPR26-deficient mice display increased anxiety- and depression-like behaviors accompanied by reduced phosphorylated cyclic AMP responsive element-binding protein level in central amygdala.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173410.3 → NP_775586.1  G-protein coupled receptor 26

    See identical proteins and their annotated locations for NP_775586.1

    Status: PROVISIONAL

    Source sequence(s)
    AC105062
    Consensus CDS
    CCDS21920.1
    UniProtKB/Swiss-Prot
    Q80T55, Q8BXZ5, Q8BZA7
    UniProtKB/TrEMBL
    Q0VBG4
    Related
    ENSMUSP00000041664.5, ENSMUST00000045840.5
    Conserved Domains (1) summary
    cd15219
    Location:7 → 305
    7tmA_GPR26_GPR78-like; G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    131567891..131587362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507766.4 → XP_006507829.1  G-protein coupled receptor 26 isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:7 → 33
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:7 → 261
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZA7.1 GenPept UniProtKB/Swiss-Prot:Q8BZA7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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