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Cbr4 carbonyl reductase 4 [ Mus musculus (house mouse) ]

Gene ID: 234309, updated on 27-Dec-2024

Summary

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Official Symbol
Cbr4provided by MGI
Official Full Name
carbonyl reductase 4provided by MGI
Primary source
MGI:MGI:2384567
See related
Ensembl:ENSMUSG00000031641 AllianceGenome:MGI:2384567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A730083J17Rik
Summary
Predicted to enable several functions, including 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NADPH binding activity; and NADPH dehydrogenase (quinone) activity. Predicted to be involved in fatty acid biosynthetic process; glycoside metabolic process; and protein tetramerization. Located in mitochondrion. Orthologous to human CBR4 (carbonyl reductase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 7.8), heart adult (RPKM 7.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Cbr4 in Genome Data Viewer
Location:
8 B3.1; 8 31.18 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (61940768..61956534)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (61487734..61503500)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene SH3 domain containing ring finger 1 Neighboring gene RIKEN cDNA 5730405A17 gene Neighboring gene STARR-positive B cell enhancer ABC_E10501 Neighboring gene STARR-seq mESC enhancer starr_21586 Neighboring gene predicted gene, 53435 Neighboring gene STARR-seq mESC enhancer starr_21587 Neighboring gene STARR-seq mESC enhancer starr_21588 Neighboring gene STARR-seq mESC enhancer starr_21589 Neighboring gene palladin, cytoskeletal associated protein Neighboring gene STARR-seq mESC enhancer starr_21591 Neighboring gene STARR-seq mESC enhancer starr_21593 Neighboring gene predicted gene, 35254 Neighboring gene STARR-seq mESC enhancer starr_21597 Neighboring gene predicted gene, 51576

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression. Chiang DY, et al. Circulation, 2018 Oct 9. PMID 29669786, Free PMC Article
  2. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article
  3. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
  4. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC6971

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NAD(P)H dehydrogenase (quinone) activity ISO
Inferred from Sequence Orthology
more info
  
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
  
enables NADPH binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NADPH dehydrogenase (quinone) activity ISO
Inferred from Sequence Orthology
more info
  
enables NADPH dehydrogenase (quinone) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables quinone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables quinone binding ISO
Inferred from Sequence Orthology
more info
  
enables quinone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in daunorubicin metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in daunorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in doxorubicin metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in doxorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein heterotetramerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein heterotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein homotetramerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
part_of oxidoreductase complex ISO
Inferred from Sequence Orthology
more info
  
part_of oxidoreductase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
3-oxoacyl-[acyl-carrier-protein] reductase
Names
3-ketoacyl-[acyl-carrier-protein] reductase beta subunit
KAR beta subunit
carbonyl reductase family member 4
quinone reductase CBR4
NP_663570.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145595.2 → NP_663570.2  3-oxoacyl-[acyl-carrier-protein] reductase

    See identical proteins and their annotated locations for NP_663570.2

    Status: VALIDATED

    Source sequence(s)
    AK043313, AK150763
    Consensus CDS
    CCDS40349.1
    UniProtKB/Swiss-Prot
    Q3UBY4, Q8BXV1, Q91VT4
    Related
    ENSMUSP00000034058.7, ENSMUST00000034058.14
    Conserved Domains (2) summary
    PRK05653
    Location:1 → 234
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated
    cl21454
    Location:3 → 232
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    61940768..61956534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VT4.2 GenPept UniProtKB/Swiss-Prot:Q91VT4

Gene LinkOut

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