Nxnl1 nucleoredoxin-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nxnl1provided by MGI
Official Full Name: nucleoredoxin-like 1provided by MGI
Primary source: MGI:MGI:1924446
See related: Ensembl:ENSMUSG00000034829 AllianceGenome:MGI:1924446
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RdCVF; Txnl6; A930031O08Rik
Summary: Involved in photoreceptor cell maintenance. Located in mitochondrion. Is expressed in several structures, including cerebellum external granule cell layer; neural retina; and olfactory epithelium. Orthologous to human NXNL1 (nucleoredoxin like 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in adrenal adult (RPKM 2.3), thymus adult (RPKM 1.1) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.43 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (72013211..72019291, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (71560555..71566649, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NXNL1 negatively regulates osteoblast differentiation via GDF15-induced PP2A Calpha dependent manner in MC3T3-E1 cells.
Title: NXNL1 negatively regulates osteoblast differentiation via GDF15-induced PP2A Cα dependent manner in MC3T3-E1 cells.
RdCVFL is a cell-autonomous mechanism of protection.
Title: The Thioredoxin Encoded by the Rod-Derived Cone Viability Factor Gene Protects Cone Photoreceptors Against Oxidative Stress.
Study shows that RdCVF acts through binding to Basigin-1 (BSG1), a transmembrane protein expressed specifically by photoreceptors. BSG1 binds to the glucose transporter GLUT1, resulting in increased glucose entry into cones.
Title: Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis.
The Nxnl1 gene, through the thioredoxin RdCVF-long isoform, is part of an endogenous defense mechanism against photooxidative stress.
Title: Thioredoxin rod-derived cone viability factor protects against photooxidative retinal damage.
regulation of the Nucleoredoxin-like genes involves a CRX responsive element that can act as both as a positive regulator of promoter activity and as a modulator of cell-type specificity
Title: Expression of rod-derived cone viability factor: dual role of CRX in regulating promoter activity and cell-type specificity.
The RdCVF gene has an essential role in photoreceptor maintenance and resistance to retinal oxidative stress.
Title: The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress.
CHX10 regulates RdCVF promoter activity in the inner retina.
Title: The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina.
functional interaction between RdCVFL and TAU described here is the first characterization of the RdCVFL signaling pathway involved in neuronal cell death mediated by oxidative stress
Title: The thioredoxin-like protein rod-derived cone viability factor (RdCVFL) interacts with TAU and inhibits its phosphorylation in the retina.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
located_in photoreceptor outer segment	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleoredoxin-like protein 1

Names: rod-derived cone viability factor; thioredoxin-like 6; thioredoxin-like protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145598.3 → NP_663573.1 nucleoredoxin-like protein 1

See identical proteins and their annotated locations for NP_663573.1

Status: VALIDATED

Source sequence(s)

AC162033

Consensus CDS

CCDS40385.1

UniProtKB/Swiss-Prot

Q8VC33, Q91W38

Related

ENSMUSP00000127094.2, ENSMUST00000163659.3

Conserved Domains (1) summary

cd03008
Location:8 → 153

TryX_like_RdCVF; Tryparedoxin (TryX)-like family, Rod-derived cone viability factor (RdCVF) subfamily; RdCVF is a thioredoxin (TRX)-like protein specifically expressed in photoreceptors. RdCVF was isolated and identified as a factor that supports cone survival in retinal ...