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Ces4a carboxylesterase 4A [ Mus musculus (house mouse) ]

Gene ID: 234677, updated on 9-Dec-2024

Summary

Official Symbol
Ces4aprovided by MGI
Official Full Name
carboxylesterase 4Aprovided by MGI
Primary source
MGI:MGI:2384581
See related
Ensembl:ENSMUSG00000060560 AllianceGenome:MGI:2384581
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ces8
Summary
Predicted to enable carboxylic ester hydrolase activity. Predicted to be located in extracellular region. Is expressed in exocrine gland; genitourinary system; skin; and thyroid gland. Orthologous to human CES4A (carboxylesterase 4A). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Ces4a in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105858432..105876741)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105131800..105150109)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carboxylesterase 3B Neighboring gene STARR-positive B cell enhancer ABC_E5035 Neighboring gene microtubule-associated protein, RP/EB family, member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22521 Neighboring gene predicted gene, 51414 Neighboring gene STARR-positive B cell enhancer ABC_E1106 Neighboring gene predicted gene, 22063 Neighboring gene core binding factor beta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General protein information

Preferred Names
carboxylesterase 4A
Names
carboxylesterase 8 (putative)
NP_666325.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146213.2NP_666325.2  carboxylesterase 4A precursor

    See identical proteins and their annotated locations for NP_666325.2

    Status: VALIDATED

    Source sequence(s)
    AC164311, AK037191, AV235376
    Consensus CDS
    CCDS22591.2
    UniProtKB/Swiss-Prot
    G3XA24, Q8R0W5
    Related
    ENSMUSP00000125062.2, ENSMUST00000161289.2
    Conserved Domains (2) summary
    COG0657
    Location:128272
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:30554
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    105858432..105876741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)