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Deup1 deuterosome assembly protein 1 [ Mus musculus (house mouse) ]

Gene ID: 234964, updated on 18-Sep-2024

Summary

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Official Symbol
Deup1provided by MGI
Official Full Name
deuterosome assembly protein 1provided by MGI
Primary source
MGI:MGI:2443026
See related
Ensembl:ENSMUSG00000039977 AllianceGenome:MGI:2443026
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc67; 4933401K09Rik
Summary
Predicted to enable identical protein binding activity. Involved in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation. Located in deuterosome. Is expressed in several structures, including brain; male reproductive gland or organ; olfactory epithelium; respiratory system; and thyroid gland. Orthologous to human DEUP1 (deuterosome assembly protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 25.8) See more
Orthologs
human all
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Genomic context

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See Deup1 in Genome Data Viewer
Location:
9 A2; 9 5.0 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15471160..15539646, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15559864..15628351, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene single-pass membrane protein with coiled-coil domains 4 Neighboring gene predicted gene, 35176 Neighboring gene STARR-positive B cell enhancer ABC_E2281 Neighboring gene predicted gene, 51703 Neighboring gene STARR-seq mESC enhancer starr_23385 Neighboring gene predicted gene, 46152 Neighboring gene STARR-seq mESC enhancer starr_23386 Neighboring gene RIKEN cDNA 4930540M03 gene Neighboring gene predicted gene, 39295 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 pseudogene Neighboring gene predicted gene, 35225

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Biophysical and biochemical properties of Deup1 self-assemblies: a potential driver for deuterosome formation during multiciliogenesis. Yamamoto S, et al. Biol Open, 2021 Mar 3. PMID 33658185, Free PMC Article
  2. Massive centriole production can occur in the absence of deuterosomes in multiciliated cells. Mercey O, et al. Nat Cell Biol, 2019 Dec. PMID 31792378, Free PMC Article
  3. The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Zhao H, et al. Nat Cell Biol, 2013 Dec. PMID 24240477
  4. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. Oduru S, et al. BMC Genomics, 2003 Jun 3. PMID 12783626, Free PMC Article
  5. Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Otto T, et al. Proc Natl Acad Sci U S A, 2017 Oct 3. PMID 28923932, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deup1 Expression Interferes with Multiciliated Differentiation.
    Title: Deup1 Expression Interferes with Multiciliated Differentiation.
  2. Biophysical and biochemical properties of Deup1 self-assemblies: a potential driver for deuterosome formation during multiciliogenesis.
    Title: Biophysical and biochemical properties of Deup1 self-assemblies: a potential driver for deuterosome formation during multiciliogenesis.
  3. Deup1 governs deuterosome assembly to mediate large-scale de novo centriole biogenesis.
    Title: The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in multi-ciliated epithelial cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in deuterosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in deuterosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
deuterosome assembly protein 1
Names
coiled-coil domain containing 67
coiled-coil domain-containing protein 67
deuterosomal protein 1
deuterosome protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001373917.1 → NP_001360846.1  deuterosome assembly protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC155249
    Consensus CDS
    CCDS90502.1
    UniProtKB/Swiss-Prot
    E9QL16, Q4VA46, Q7M6Y5
    Related
    ENSMUSP00000039912.7, ENSMUST00000045513.13
    Conserved Domains (2) summary
    PRK03918
    Location:211 → 466
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa

  2. NM_001373918.1 → NP_001360847.1  deuterosome assembly protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC155249
    Conserved Domains (2) summary
    PRK03918
    Location:220 → 445
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam17045
    Location:1 → 258
    CEP63; Centrosomal protein of 63 kDa

  3. NM_001373919.1 → NP_001360848.1  deuterosome assembly protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC155249
    Conserved Domains (2) summary
    PRK03918
    Location:209 → 434
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam17045
    Location:12 → 247
    CEP63; Centrosomal protein of 63 kDa

  4. NM_001373920.1 → NP_001360849.1  deuterosome assembly protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC155249
    UniProtKB/TrEMBL
    U5KUF9
    Conserved Domains (1) summary
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa

  5. NM_001373921.1 → NP_001360850.1  deuterosome assembly protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC155249
    UniProtKB/TrEMBL
    D3Z2N8
    Related
    ENSMUSP00000121526.2, ENSMUST00000152377.2
    Conserved Domains (2) summary
    PRK03918
    Location:241 → 409
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa

  6. NM_181816.3 → NP_861537.2  deuterosome assembly protein 1 isoform 5

    See identical proteins and their annotated locations for NP_861537.2

    Status: VALIDATED

    Source sequence(s)
    AC155249
    Consensus CDS
    CCDS22839.2
    UniProtKB/Swiss-Prot
    Q7M6Y5
    Related
    ENSMUSP00000111256.4, ENSMUST00000115593.10
    Conserved Domains (1) summary
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    15471160..15539646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510165.3 → XP_006510228.1  deuterosome assembly protein 1 isoform X3

    Conserved Domains (2) summary
    PRK03918
    Location:211 → 466
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa

  2. XM_036154860.1 → XP_036010753.1  deuterosome assembly protein 1 isoform X5

    Conserved Domains (1) summary
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa

  3. XM_006510166.3 → XP_006510229.1  deuterosome assembly protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006510229.1

    UniProtKB/TrEMBL
    U5KUF9
    Conserved Domains (1) summary
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa

  4. XM_006510159.4 → XP_006510222.1  deuterosome assembly protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006510222.1

    UniProtKB/Swiss-Prot
    E9QL16, Q4VA46, Q7M6Y5
    Conserved Domains (2) summary
    PRK03918
    Location:211 → 466
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa

  5. XM_030244280.2 → XP_030100140.1  deuterosome assembly protein 1 isoform X4

    UniProtKB/TrEMBL
    U5KUF9
    Conserved Domains (1) summary
    pfam17045
    Location:12 → 279
    CEP63; Centrosomal protein of 63 kDa

  6. XM_011242458.3 → XP_011240760.1  deuterosome assembly protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011240760.1

    Conserved Domains (2) summary
    PRK03918
    Location:220 → 445
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam17045
    Location:1 → 258
    CEP63; Centrosomal protein of 63 kDa

  7. XM_006510163.4 → XP_006510226.1  deuterosome assembly protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006510226.1

    Conserved Domains (2) summary
    PRK03918
    Location:220 → 445
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam17045
    Location:1 → 258
    CEP63; Centrosomal protein of 63 kDa

  8. XM_006510164.4 → XP_006510227.1  deuterosome assembly protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006510227.1

    Conserved Domains (2) summary
    PRK03918
    Location:220 → 445
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam17045
    Location:1 → 258
    CEP63; Centrosomal protein of 63 kDa

  9. XM_011242457.3 → XP_011240759.1  deuterosome assembly protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011240759.1

    Conserved Domains (2) summary
    PRK03918
    Location:220 → 445
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam17045
    Location:1 → 258
    CEP63; Centrosomal protein of 63 kDa

  10. XM_006510161.4 → XP_006510224.1  deuterosome assembly protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006510224.1

    Conserved Domains (2) summary
    PRK03918
    Location:220 → 445
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam17045
    Location:1 → 258
    CEP63; Centrosomal protein of 63 kDa

RNA

  1. XR_003947864.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7M6Y5.3 GenPept UniProtKB/Swiss-Prot:Q7M6Y5

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