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Fez1 fasciculation and elongation protein zeta 1 [ Mus musculus (house mouse) ]

Gene ID: 235180, updated on 9-Dec-2024

Summary

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Official Symbol
Fez1provided by MGI
Official Full Name
fasciculation and elongation protein zeta 1provided by MGI
Primary source
MGI:MGI:2670976
See related
Ensembl:ENSMUSG00000032118 AllianceGenome:MGI:2670976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UNC76; UNC-76
Summary
Enables gamma-tubulin binding activity. Predicted to be involved in several processes, including negative regulation of autophagosome assembly; positive regulation of anterograde axonal transport of mitochondrion; and positive regulation of neuron projection development. Located in centrosome and cytoplasm. Is expressed in several structures, including brain and spinal cord. Orthologous to human FEZ1 (fasciculation and elongation protein zeta 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in CNS E18 (RPKM 83.7), cerebellum adult (RPKM 71.7) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Fez1 in Genome Data Viewer
Location:
9 A4; 9 20.69 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (36732694..36790220)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (36821398..36878926)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E709 Neighboring gene STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) Neighboring gene predicted gene, 26787 Neighboring gene etoposide induced 2.4 mRNA Neighboring gene predicted gene 27219 Neighboring gene STARR-seq mESC enhancer starr_23786 Neighboring gene STARR-seq mESC enhancer starr_23787 Neighboring gene Pbx/knotted 1 homeobox 2 Neighboring gene predicted gene, 34652 Neighboring gene VISTA enhancer mm577 Neighboring gene predicted gene, 34538

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fez1 is layer-specifically expressed in the adult mouse neocortex. Inoue K, et al. Eur J Neurosci, 2004 Dec. PMID 15579145
  2. Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice. Bryant DT, et al. Sci Rep, 2017 Sep 19. PMID 28928414, Free PMC Article
  3. Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. Kang E, et al. Neuron, 2011 Nov 17. PMID 22099459, Free PMC Article
  4. Dendrite development regulated by the schizophrenia-associated gene FEZ1 involves the ubiquitin proteasome system. Watanabe Y, et al. Cell Rep, 2014 Apr 24. PMID 24726361
  5. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. Fujita T, et al. Biochem Biophys Res Commun, 2004 Jan 16. PMID 14697253

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of HDAC11 had no obvious impact on brain morphology and neural stem/precursor cells isolated from Hdac11 (KO/KO) mice had comparable proliferation and differentiation characteristics. However, in differentiating neural cells this study observed decreased expression of schizophrenia-associated gene Fez1.
    Title: Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice.
  2. Phosphorylation of FEZ1 by MARK regulates its function in presynaptic protein trafficking.
    Title: Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking.
  3. Dendrite growth depends on degradation of FEZ1 regulated by Cdc20/APC.
    Title: Dendrite development regulated by the schizophrenia-associated gene FEZ1 involves the ubiquitin proteasome system.
  4. Fezzeta-1 interacts with disrupted in schizophrenia (DISC)1 to synergistically regulate dendritic growth of newborn neurons in the adult mouse hippocampus.
    Title: Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia.
  5. investigated the role of FEZ1 in brain development and the pathogenesis of schizophrenia by generating mice that lack Fez1
    Title: Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants.
  6. Fez1 is mainly expressed in cortical layers V and VI, not in gamma-aminobutyric acid neurons but in pyramidal neurons, the projection neurons of the cerebral cortex. Immunohistochemistry also shows that Fez1 is expressed in deep layers of the neocortex.
    Title: Fez1 is layer-specifically expressed in the adult mouse neocortex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC19293

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables gamma-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase C binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of mitochondrion localization IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of mitochondrion localization ISO
Inferred from Sequence Orthology
more info
  
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of autophagosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of anterograde axonal transport of mitochondrion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of anterograde axonal transport of mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fasciculation and elongation protein zeta-1
Names
zygin I
zygin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357610.1 → NP_001344539.1  fasciculation and elongation protein zeta-1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All six transcripts encode the same protein.
    Source sequence(s)
    CT009699, CT955982
    Consensus CDS
    CCDS40581.1
    UniProtKB/Swiss-Prot
    Q3YE74, Q8K0X8
    Conserved Domains (1) summary
    pfam07763
    Location:58 → 297
    FEZ; FEZ-like protein

  2. NM_001357611.1 → NP_001344540.1  fasciculation and elongation protein zeta-1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    CT009699
    Consensus CDS
    CCDS40581.1
    UniProtKB/Swiss-Prot
    Q3YE74, Q8K0X8
    Conserved Domains (1) summary
    pfam07763
    Location:58 → 297
    FEZ; FEZ-like protein

  3. NM_001357612.1 → NP_001344541.1  fasciculation and elongation protein zeta-1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    CT009699, CT955982
    Consensus CDS
    CCDS40581.1
    UniProtKB/Swiss-Prot
    Q3YE74, Q8K0X8
    Conserved Domains (1) summary
    pfam07763
    Location:58 → 297
    FEZ; FEZ-like protein

  4. NM_001357613.2 → NP_001344542.1  fasciculation and elongation protein zeta-1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    CT009699
    Consensus CDS
    CCDS40581.1
    UniProtKB/Swiss-Prot
    Q3YE74, Q8K0X8
    Conserved Domains (1) summary
    pfam07763
    Location:58 → 297
    FEZ; FEZ-like protein

  5. NM_001357614.1 → NP_001344543.1  fasciculation and elongation protein zeta-1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    CT009699
    Consensus CDS
    CCDS40581.1
    UniProtKB/Swiss-Prot
    Q3YE74, Q8K0X8
    Related
    ENSMUSP00000126072.2, ENSMUST00000163816.8
    Conserved Domains (1) summary
    pfam07763
    Location:58 → 297
    FEZ; FEZ-like protein

  6. NM_001421510.1 → NP_001408439.1  fasciculation and elongation protein zeta-1

    Status: VALIDATED

    Source sequence(s)
    CT009699

  7. NM_183171.6 → NP_898994.2  fasciculation and elongation protein zeta-1

    See identical proteins and their annotated locations for NP_898994.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    CT009699
    Consensus CDS
    CCDS40581.1
    UniProtKB/Swiss-Prot
    Q3YE74, Q8K0X8
    Related
    ENSMUSP00000034630.9, ENSMUST00000034630.15
    Conserved Domains (1) summary
    pfam07763
    Location:58 → 297
    FEZ; FEZ-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    36732694..36790220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244292.2 → XP_030100152.1  fasciculation and elongation protein zeta-1 isoform X1

    UniProtKB/Swiss-Prot
    Q3YE74, Q8K0X8
    Conserved Domains (1) summary
    pfam07763
    Location:58 → 297
    FEZ; FEZ-like protein

  2. XM_030244293.2 → XP_030100153.1  fasciculation and elongation protein zeta-1 isoform X1

    UniProtKB/Swiss-Prot
    Q3YE74, Q8K0X8
    Conserved Domains (1) summary
    pfam07763
    Location:58 → 297
    FEZ; FEZ-like protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0X8.2 GenPept UniProtKB/Swiss-Prot:Q8K0X8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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