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ZNF281 zinc finger protein 281 [ Homo sapiens (human) ]

Gene ID: 23528, updated on 3-Nov-2024

Summary

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Official Symbol
ZNF281provided by HGNC
Official Full Name
zinc finger protein 281provided by HGNC
Primary source
HGNC:HGNC:13075
See related
Ensembl:ENSG00000162702 MIM:618703; AllianceGenome:HGNC:13075
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GZP1; ZBP99; ZBP-99; ZNP-99
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; and positive regulation of DNA-templated transcription. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 10.1), appendix (RPKM 5.7) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF281 in Genome Data Viewer
Location:
1q32.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (200404951..200410036, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (199661900..199740523, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (200374079..200379164, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1669 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:200271617-200271834 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200321702-200322202 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200322203-200322703 Neighboring gene long intergenic non-protein coding RNA 862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200324513-200325012 Neighboring gene Sharpr-MPRA regulatory regions 7059 and 708 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200341274-200341804 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:200343201-200344400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2297 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200378413-200378990 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:200378991-200379568 Neighboring gene NANOG hESC enhancer GRCh37_chr1:200379569-200380146 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:200380418-200381024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200385505-200386006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200386007-200386506 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200388206-200388706 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200388707-200389207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200396646-200397146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200397147-200397647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2300 Neighboring gene uncharacterized LOC124900414 Neighboring gene uncharacterized LOC124904480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1671 Neighboring gene uncharacterized LOC107985459

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF281 Regulates Cell Proliferation, Migration and Invasion in Colorectal Cancer through Wnt/β-Catenin Signaling. Qin CJ, et al. Cell Physiol Biochem, 2019. PMID 31112017
  2. Transcription Factor ZNF281: A Novel Player in Intestinal Inflammation and Fibrosis. Pierdomenico M, et al. Front Immunol, 2018. PMID 30619271, Free PMC Article
  3. ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining. Nicolai S, et al. Oncogene, 2020 Jan. PMID 31570788, Free PMC Article
  4. ZNF281 Promotes Colon Fibroblast Activation in TGFβ1-Induced Gut Fibrosis. Laudadio I, et al. Int J Mol Sci, 2022 Sep 6. PMID 36142169, Free PMC Article
  5. ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma. Pieraccioli M, et al. Proc Natl Acad Sci U S A, 2018 Jul 10. PMID 29941555, Free PMC Article

See all (105) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cancer-associated fibroblasts facilitate premetastatic niche formation through lncRNA SNHG5-mediated angiogenesis and vascular permeability in breast cancer.
    Title: Cancer-associated fibroblasts facilitate premetastatic niche formation through lncRNA SNHG5-mediated angiogenesis and vascular permeability in breast cancer.
  2. ZNF281 Promotes Colon Fibroblast Activation in TGFbeta1-Induced Gut Fibrosis.
    Title: ZNF281 Promotes Colon Fibroblast Activation in TGFβ1-Induced Gut Fibrosis.
  3. Cervical carcinoma progression is aggravated by lncRNA ZNF281 by binding KLF15.
    Title: Cervical carcinoma progression is aggravated by lncRNA ZNF281 by binding KLF15.
  4. ZNF281/Zfp281 is a target of miR-1 and counteracts muscle differentiation.
    Title: ZNF281/Zfp281 is a target of miR-1 and counteracts muscle differentiation.
  5. ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining.
    Title: ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining.
  6. LncRNA-ZNF281 Interacts with miR-539 to Promote Hepatocellular Carcinoma Cell Invasion and Migration.
    Title: LncRNA-ZNF281 Interacts with miR-539 to Promote Hepatocellular Carcinoma Cell Invasion and Migration.
  7. Analyses indicated that circAGFG1 acts as a sponge for miR-203 to repress the effect of miR-203 on its target, ZNF281. In conclusion, study suggests that circAGFG1 promotes NSCLC growth and metastasis though a circAGFG1/miR-203/ZNF281 axis.
    Title: CircAGFG1 sponges miR-203 to promote EMT and metastasis of non-small-cell lung cancer by upregulating ZNF281 expression.
  8. Data indicate transcription factor ZNF281 as a player of intestinal inflammation and fibrosis, and in the pathogenetic mechanisms underlying inflammatory bowel disease.
    Title: Transcription Factor ZNF281: A Novel Player in Intestinal Inflammation and Fibrosis.
  9. ZNF281 mRNA and protein levels were significantly increased in colorectal cancer (CRC) tissues compared with normal colon tissues, and high ZNF281 expression was associated with advanced T stage, N stage, TNM stage and differentiation. Therefore, ZNF281 expression might be an independent prognostic indicator in CRC patients.
    Title: ZNF281 Regulates Cell Proliferation, Migration and Invasion in Colorectal Cancer through Wnt/β-Catenin Signaling.
  10. These observations suggest that ZNF281 is a controller of neuronal differentiation that should be evaluated as a prognostic marker in neuroblastoma.
    Title: ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12859, FLJ14378

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryonic body morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 281
Names
GC-box-binding zinc finger protein 1
ZNP-99 transcription factor
transcription factor ZBP-99
zinc finger DNA-binding protein 99

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281293.2 → NP_001268222.1  zinc finger protein 281 isoform 1

    See identical proteins and their annotated locations for NP_001268222.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC104461, AJ132592, BP216938
    Consensus CDS
    CCDS1402.1
    UniProtKB/Swiss-Prot
    A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9
    Related
    ENSP00000356322.1, ENST00000367353.2
    Conserved Domains (2) summary
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:331 → 356
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001281294.2 → NP_001268223.1  zinc finger protein 281 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC104461, AK022921, AK094701, BC051905, BG611294, DB150929
    Consensus CDS
    CCDS60384.1
    UniProtKB/Swiss-Prot
    Q9Y2X9
    UniProtKB/TrEMBL
    B3KMX4
    Related
    ENSP00000356321.3, ENST00000367352.3
    Conserved Domains (3) summary
    sd00017
    Location:227 → 247
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:225 → 247
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:295 → 320
    zf-H2C2_2; Zinc-finger double domain

  3. NM_012482.5 → NP_036614.1  zinc finger protein 281 isoform 1

    See identical proteins and their annotated locations for NP_036614.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC104461, BC060820
    Consensus CDS
    CCDS1402.1
    UniProtKB/Swiss-Prot
    A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9
    Related
    ENSP00000294740.2, ENST00000294740.3
    Conserved Domains (2) summary
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:331 → 356
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    200404951..200410036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    199661900..199740523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335706.1 → XP_054191681.1  zinc finger protein 281 isoform X1

    UniProtKB/Swiss-Prot
    A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9

  2. XM_054335707.1 → XP_054191682.1  zinc finger protein 281 isoform X1

    UniProtKB/Swiss-Prot
    A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9

  3. XM_054335708.1 → XP_054191683.1  zinc finger protein 281 isoform X1

    UniProtKB/Swiss-Prot
    A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2X9.1 GenPept UniProtKB/Swiss-Prot:Q9Y2X9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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