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Ppp2r3a protein phosphatase 2, regulatory subunit B'', alpha [ Mus musculus (house mouse) ]

Gene ID: 235542, updated on 9-Dec-2024

Summary

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Official Symbol
Ppp2r3aprovided by MGI
Official Full Name
protein phosphatase 2, regulatory subunit B'', alphaprovided by MGI
Primary source
MGI:MGI:2442104
See related
Ensembl:ENSMUSG00000043154 AllianceGenome:MGI:2442104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A730042E07; 3222402P14Rik; C530025M11Rik
Summary
Predicted to enable protein phosphatase regulator activity and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including regulation of canonical Wnt signaling pathway; regulation of cell migration involved in somitogenic axis elongation; and somitogenesis. Predicted to be part of protein phosphatase type 2A complex. Is expressed in several structures, including genitourinary system; heart; liver; musculature; and spleen. Orthologous to human PPP2R3A (protein phosphatase 2 regulatory subunit B''alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in heart adult (RPKM 13.2), CNS E18 (RPKM 5.5) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp2r3a in Genome Data Viewer
Location:
9 E4; 9 53.19 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (100982188..101129031, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (101104989..101251832, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5097 Neighboring gene predicted gene, 46140 Neighboring gene MSL complex subunit 2 Neighboring gene predicted gene, 24338 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25048 Neighboring gene predicted gene 28979

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A. Zwaenepoel K, et al. BMC Genomics, 2008 Aug 20. PMID 18715506, Free PMC Article
  2. Protein phosphatase 2A PR130/B''alpha1 subunit binds to the SH2 domain-containing inositol polyphosphate 5-phosphatase 2 and prevents epidermal growth factor (EGF)-induced EGF receptor degradation sustaining EGF-mediated signaling. Zwaenepoel K, et al. FASEB J, 2010 Feb. PMID 19825976
  3. Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module. Koss M, et al. Dev Cell, 2012 May 15. PMID 22560297, Free PMC Article
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC29057

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in eye photoreceptor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell migration involved in somitogenic axis elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell migration involved in somitogenic axis elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in somatic muscle development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in somatic muscle development ISO
Inferred from Sequence Orthology
more info
  
involved_in somitogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in somitogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
NP_001154834.1
NP_742156.2
XP_006511767.1
XP_017168836.1
XP_017168837.1
XP_017168838.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161362.3 → NP_001154834.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_001154834.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK042943, AK076163, AK132175, BU758090, CJ100577, CX220062
    Consensus CDS
    CCDS52900.1
    UniProtKB/TrEMBL
    B2RXC8
    Related
    ENSMUSP00000075327.6, ENSMUST00000075941.12
    Conserved Domains (2) summary
    pfam13499
    Location:899 → 1000
    EF-hand_7; EF-hand domain pair
    pfam17958
    Location:795 → 884
    EF-hand_13; EF-hand domain

  2. NM_172144.3 → NP_742156.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 2

    See identical proteins and their annotated locations for NP_742156.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, and uses a distinct translation start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK132175, BU758090, CK621911, CX220062
    Consensus CDS
    CCDS52899.1
    UniProtKB/TrEMBL
    G3X9E8, Q3V1Y6
    Related
    ENSMUSP00000069688.8, ENSMUST00000066773.9
    Conserved Domains (1) summary
    pfam13499
    Location:282 → 380
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    100982188..101129031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313347.2 → XP_017168836.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1

    UniProtKB/TrEMBL
    B2RXC8
    Conserved Domains (2) summary
    pfam13499
    Location:899 → 1000
    EF-hand_7; EF-hand domain pair
    pfam17958
    Location:795 → 884
    EF-hand_13; EF-hand domain

  2. XM_006511704.5 → XP_006511767.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X4

    UniProtKB/TrEMBL
    Q3V1Y6
    Conserved Domains (2) summary
    pfam13499
    Location:236 → 337
    EF-hand_7; EF-hand domain pair
    pfam17958
    Location:132 → 221
    EF-hand_13; EF-hand domain

  3. XM_017313349.2 → XP_017168838.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X3

    Conserved Domains (2) summary
    pfam13499
    Location:899 → 1000
    EF-hand_7; EF-hand domain pair
    pfam17958
    Location:795 → 884
    EF-hand_13; EF-hand domain

  4. XM_017313348.2 → XP_017168837.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:899 → 1000
    EF-hand_7; EF-hand domain pair
    pfam17958
    Location:795 → 884
    EF-hand_13; EF-hand domain

RNA

  1. XR_001778885.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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