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FPR2 formyl peptide receptor 2 [ Homo sapiens (human) ]

Gene ID: 2358, updated on 27-Nov-2024

Summary

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Official Symbol
FPR2provided by HGNC
Official Full Name
formyl peptide receptor 2provided by HGNC
Primary source
HGNC:HGNC:3827
See related
Ensembl:ENSG00000171049 MIM:136538; AllianceGenome:HGNC:3827
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALX; ALXR; HM63; FMLPX; FPR2A; FPRH1; FPRH2; FPRL1; LXA4R; FMLP-R-II
Summary
Enables amyloid-beta binding activity; scavenger receptor binding activity; and signaling receptor activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of ERK1 and ERK2 cascade; and regulation of defense response. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in appendix (RPKM 23.5), spleen (RPKM 4.6) and 5 other tissues See more
Orthologs
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Genomic context

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See FPR2 in Genome Data Viewer
Location:
19q13.41
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51761180..51770531)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54839202..54857725)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52264433..52273784)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904754 Neighboring gene Sharpr-MPRA regulatory region 4853 Neighboring gene formyl peptide receptor 1 Neighboring gene Sharpr-MPRA regulatory region 3543 Neighboring gene uncharacterized LOC105372448 Neighboring gene formyl peptide receptor 3 Neighboring gene zinc finger protein 577

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Formyl Peptide Receptor 2 Plays a Deleterious Role During Influenza A Virus Infections. Tcherniuk S, et al. J Infect Dis, 2016 Jul 15. PMID 27034344
  2. Role of formyl peptide receptor 2 in homing of endothelial progenitor cells and therapeutic angiogenesis. Jang IH, et al. Adv Biol Regul, 2015 Jan. PMID 25304660
  3. Identification of a novel recycling sequence in the C-tail of FPR2/ALX receptor: association with cell protection from apoptosis. Thompson D, et al. J Biol Chem, 2014 Dec 26. PMID 25326384, Free PMC Article
  4. Antiinflammatory mediator lipoxin A4 and its receptor in synovitis of patients with rheumatoid arthritis. Hashimoto A, et al. J Rheumatol, 2007 Nov. PMID 17918787
  5. The proteolytically stable peptidomimetic Pam-(Lys-βNSpe)6-NH2 selectively inhibits human neutrophil activation via formyl peptide receptor 2. Skovbakke SL, et al. Biochem Pharmacol, 2015 Jan 15. PMID 25462815

See all (171) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The G-Protein-Coupled Formyl Peptide Receptor 2 Promotes Endothelial-Mesenchymal Transition in Diabetic Retinopathy.
    Title: The G-Protein-Coupled Formyl Peptide Receptor 2 Promotes Endothelial-Mesenchymal Transition in Diabetic Retinopathy.
  2. Formyl-peptide receptor 2 signalling triggers aerobic metabolism of glucose through Nox2-dependent modulation of pyruvate dehydrogenase activity.
    Title: Formyl-peptide receptor 2 signalling triggers aerobic metabolism of glucose through Nox2-dependent modulation of pyruvate dehydrogenase activity.
  3. Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver.
    Title: Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver.
  4. Formyl peptide receptor 2 and heart disease.
    Title: Formyl peptide receptor 2 and heart disease.
  5. Downregulated formyl peptide receptor 2 expression in the epileptogenic foci of patients with focal cortical dysplasia type IIb and tuberous sclerosis complex.
    Title: Downregulated formyl peptide receptor 2 expression in the epileptogenic foci of patients with focal cortical dysplasia type IIb and tuberous sclerosis complex.
  6. Resolution of inflammation via RvD1/FPR2 signaling mitigates Nox2 activation and ferroptosis of macrophages in experimental abdominal aortic aneurysms.
    Title: Resolution of inflammation via RvD1/FPR2 signaling mitigates Nox2 activation and ferroptosis of macrophages in experimental abdominal aortic aneurysms.
  7. Single-Cell Analysis Reveals the Role of the Neuropeptide Receptor FPR2 in Monocytes in Kawasaki Disease: A Bioinformatic Study.
    Title: Single-Cell Analysis Reveals the Role of the Neuropeptide Receptor FPR2 in Monocytes in Kawasaki Disease: A Bioinformatic Study.
  8. Efferocytosis and enhanced FPR2 expression following apoptotic cell instillation attenuate radiation-induced lung inflammation and fibrosis.
    Title: Efferocytosis and enhanced FPR2 expression following apoptotic cell instillation attenuate radiation-induced lung inflammation and fibrosis.
  9. Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2.
    Title: Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2.
  10. Breast cancer metastasis to brain results in recruitment and activation of microglia through annexin-A1/formyl peptide receptor signaling.
    Title: Breast cancer metastasis to brain results in recruitment and activation of microglia through annexin-A1/formyl peptide receptor signaling.
Submit: New GeneRIF Correction See all GeneRIFs (138)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env FPRL1 is an alternative coreceptor usage by R5-tropic HIV-1 type C gp120/gp41, although its usage frequency is less than that of CCR5 coreceptor. The gp120 V3 crown is an important determinant for the efficient FPRL1 usage by the type-C virus PubMed
env A synthetic peptide domain of the V3 region of HIV-1 gp120 activates the FPRL1 receptor in monocytes and neutrophils and causes reduced response to several chemokines that use multiple cell receptors, including SDF-1alpha and RANTES PubMed
env A synthetic peptide corresponding to amino acid residues 414-434 of HIV-1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R PubMed
Envelope transmembrane glycoprotein gp41 env FPRL1 is an alternative coreceptor usage by R5-tropic HIV-1 type C gp120/gp41, although its usage frequency is less than that of CCR5 coreceptor PubMed
env Matriptase, a serine protease, efficiently cleaves the HR1 portion of HIV-1 gp41 into a 22-residue chemotactic peptide MAT-1, leading to chemotaxis by using FPR2 in primary neutrophils PubMed
env HIV-1 gp41 activates innate host immune cells through FPRL1, and the activation of FPRL1 by gp41 further induces the phosphorylation of the chemokine receptor CCR5 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables N-formyl peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amyloid-beta binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables amyloid-beta binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables complement receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables scavenger receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in calcium-mediated signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to amyloid-beta IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to amyloid-beta ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chemotaxis TAS
Traceable Author Statement
more info
 PubMed 
involved_in complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in immune response-regulating cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of monocyte chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of phagocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of superoxide anion generation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in specific granule membrane TAS
Traceable Author Statement
more info
  
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
N-formyl peptide receptor 2
Names
FMLP-R-I
FMLP-related receptor I
LXA4 receptor
RFP
formyl peptide receptor-like 1
lipoxin A4 receptor (formyl peptide receptor related)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005738.2 → NP_001005738.1  N-formyl peptide receptor 2

    See identical proteins and their annotated locations for NP_001005738.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC018755, BC071722, BM922150, D10922
    Consensus CDS
    CCDS12840.1
    UniProtKB/Swiss-Prot
    A8K3E2, P25090
    Related
    ENSP00000340191.4, ENST00000340023.7
    Conserved Domains (1) summary
    cd15117
    Location:27 → 313
    7tmA_FPR-like; N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001462.3 → NP_001453.1  N-formyl peptide receptor 2

    See identical proteins and their annotated locations for NP_001453.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    D10922, X63819
    Consensus CDS
    CCDS12840.1
    UniProtKB/Swiss-Prot
    A8K3E2, P25090
    Related
    ENSP00000468897.1, ENST00000598776.1
    Conserved Domains (1) summary
    cd15117
    Location:27 → 313
    7tmA_FPR-like; N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51761180..51770531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723120.4 → XP_006723183.1  N-formyl peptide receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_006723183.1

    UniProtKB/Swiss-Prot
    A8K3E2, P25090
    Related
    ENSP00000468876.1, ENST00000598953.1
    Conserved Domains (1) summary
    cd15117
    Location:27 → 313
    7tmA_FPR-like; N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54839202..54857725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320415.1 → XP_054176390.1  N-formyl peptide receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    A8K3E2, P25090

  2. XM_054320414.1 → XP_054176389.1  N-formyl peptide receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    A8K3E2, P25090
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25090.2 GenPept UniProtKB/Swiss-Prot:P25090

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