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Ets1 E26 avian leukemia oncogene 1, 5' domain [ Mus musculus (house mouse) ]

Gene ID: 23871, updated on 9-Dec-2024

Summary

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Official Symbol
Ets1provided by MGI
Official Full Name
E26 avian leukemia oncogene 1, 5' domainprovided by MGI
Primary source
MGI:MGI:95455
See related
Ensembl:ENSMUSG00000032035 AllianceGenome:MGI:95455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
vs; p54; Tpl1; Ets-1; D230050P06
Summary
Enables DNA-binding transcription factor activity; DNA-binding transcription factor binding activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of inflammatory response and positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ETS1 (ETS proto-oncogene 1, transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in thymus adult (RPKM 75.8), spleen adult (RPKM 42.2) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Ets1 in Genome Data Viewer
Location:
9 A4; 9 17.97 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (32547501..32669116)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (32636241..32757820)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32423579-32423876 Neighboring gene predicted gene, 31871 Neighboring gene STARR-positive B cell enhancer ABC_E1110 Neighboring gene predicted gene, 31928 Neighboring gene STARR-positive B cell enhancer ABC_E6722 Neighboring gene STARR-positive B cell enhancer ABC_E8853 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32524850-32525033 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32548707-32548914 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32548521-32548674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32555313-32555552 Neighboring gene predicted gene 3331 Neighboring gene STARR-seq mESC enhancer starr_23738 Neighboring gene STARR-seq mESC enhancer starr_23739 Neighboring gene STARR-seq mESC enhancer starr_23740 Neighboring gene STARR-seq mESC enhancer starr_23741 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32733458-32733567 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32736269-32736505 Neighboring gene predicted gene 27162

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels. Luo W, et al. J Immunol, 2014 Jul 15. PMID 24929000, Free PMC Article
  2. Ets1 regulates the differentiation and function of iNKT cells through both Pointed domain-dependent and domain-independent mechanisms. Tai TS, et al. Cell Mol Immunol, 2020 Nov. PMID 32139882, Free PMC Article
  3. Modulation of Ets-1 expression in B lymphocytes is dependent on the antigen receptor-mediated activation signals and cell cycle status. Raghunandan R, et al. Scand J Immunol, 2013 Feb. PMID 23216019
  4. Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and remodeling. Zhan Y, et al. J Clin Invest, 2005 Sep. PMID 16138193, Free PMC Article
  5. Ets-1 deficiency leads to altered B cell differentiation, hyperresponsiveness to TLR9 and autoimmune disease. Wang D, et al. Int Immunol, 2005 Sep. PMID 16051621

See all (263) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ETS1 deficiency in macrophages suppresses colorectal cancer progression by reducing the F4/80+TIM4+ macrophage population.
    Title: ETS1 deficiency in macrophages suppresses colorectal cancer progression by reducing the F4/80+TIM4+ macrophage population.
  2. M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1.
    Title: M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1.
  3. Lysine demethylase KDM3A alleviates hyperoxia-induced bronchopulmonary dysplasia in mice by promoting ETS1 expression.
    Title: Lysine demethylase KDM3A alleviates hyperoxia-induced bronchopulmonary dysplasia in mice by promoting ETS1 expression.
  4. Ets1 and IL17RA cooperate to regulate autoimmune responses and skin immunity to Staphylococcus aureus.
    Title: Ets1 and IL17RA cooperate to regulate autoimmune responses and skin immunity to Staphylococcus aureus.
  5. ETS1 Ameliorates Hyperoxia-Induced Bronchopulmonary Dysplasia in Mice by Activating Nrf2/HO-1 Mediated Ferroptosis.
    Title: ETS1 Ameliorates Hyperoxia-Induced Bronchopulmonary Dysplasia in Mice by Activating Nrf2/HO-1 Mediated Ferroptosis.
  6. Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons.
    Title: Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons.
  7. ETS1 loss in mice impairs cardiac outflow tract septation via a cell migration defect autonomous to the neural crest.
    Title: ETS1 loss in mice impairs cardiac outflow tract septation via a cell migration defect autonomous to the neural crest.
  8. B Cell Activation Results in IKK-Dependent, but Not c-Rel- or RelA-Dependent, Decreases in Transcription of the B Cell Tolerance-Inducing Gene Ets1.
    Title: B Cell Activation Results in IKK-Dependent, but Not c-Rel- or RelA-Dependent, Decreases in Transcription of the B Cell Tolerance-Inducing Gene Ets1.
  9. GATA4 Regulates Developing Endocardium Through Interaction With ETS1.
    Title: GATA4 Regulates Developing Endocardium Through Interaction With ETS1.
  10. Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.
    Title: Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.
Submit: New GeneRIF Correction See all GeneRIFs (118)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (5)  1 citation
  • Spontaneous (1) 
  • Targeted (7)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC18571, MGC130355

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding EXP
Inferred from Experiment
more info
 PubMed 
enables nucleic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in PML body organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to antibiotic ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein C-ets-1
Names
avian erythroblastosis virus E26 oncogene 1
tumor progression locus 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038642.2 → NP_001033731.1  protein C-ets-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC139108
    Consensus CDS
    CCDS40572.1
    UniProtKB/TrEMBL
    E9PWI8, Q8K3Q9
    Related
    ENSMUSP00000051303.7, ENSMUST00000050797.14
    Conserved Domains (2) summary
    cd08542
    Location:51 → 138
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    smart00413
    Location:247 → 331
    ETS; erythroblast transformation specific domain

  2. NM_001372534.1 → NP_001359463.1  protein C-ets-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127581, AC139108
    Consensus CDS
    CCDS90530.1
    UniProtKB/TrEMBL
    A0A5F8MPR7, Q921D8
    Related
    ENSMUSP00000159086.2, ENSMUST00000238819.2
    Conserved Domains (2) summary
    cd08542
    Location:95 → 182
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    smart00413
    Location:378 → 462
    ETS; erythroblast transformation specific domain

  3. NM_001372535.1 → NP_001359464.1  protein C-ets-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC139108
    UniProtKB/TrEMBL
    Q8BVW8
    Conserved Domains (2) summary
    cd08542
    Location:51 → 138
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    smart00413
    Location:333 → 417
    ETS; erythroblast transformation specific domain

  4. NM_001372536.1 → NP_001359465.1  protein C-ets-1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC139108
    UniProtKB/TrEMBL
    Q8BVW8
    Conserved Domains (2) summary
    pfam00178
    Location:270 → 348
    Ets; Ets-domain
    cl15755
    Location:51 → 68
    SAM_superfamily; SAM (Sterile alpha motif )

  5. NM_001372537.1 → NP_001359466.1  protein C-ets-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC139108
    UniProtKB/TrEMBL
    Q8K3Q9
    Conserved Domains (2) summary
    cd08542
    Location:51 → 138
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    smart00413
    Location:246 → 330
    ETS; erythroblast transformation specific domain

  6. NM_011808.3 → NP_035938.2  protein C-ets-1 isoform 1

    See identical proteins and their annotated locations for NP_035938.2

    Status: VALIDATED

    Source sequence(s)
    AC139108
    Consensus CDS
    CCDS22954.1
    UniProtKB/Swiss-Prot
    P27577, Q61403
    UniProtKB/TrEMBL
    Q540Q5, Q8BVW8
    Related
    ENSMUSP00000034534.6, ENSMUST00000034534.13
    Conserved Domains (2) summary
    cd08542
    Location:51 → 138
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    smart00413
    Location:334 → 418
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    32547501..32669116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154929.1 → XP_036010822.1  protein C-ets-1 isoform X1

    UniProtKB/TrEMBL
    Q8K3Q9
    Conserved Domains (2) summary
    cd08542
    Location:95 → 182
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    smart00413
    Location:291 → 375
    ETS; erythroblast transformation specific domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27577.2 GenPept UniProtKB/Swiss-Prot:P27577

Gene LinkOut

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