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Mief1 mitochondrial elongation factor 1 [ Mus musculus (house mouse) ]

Gene ID: 239555, updated on 9-Aug-2024

Summary

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Official Symbol
Mief1provided by MGI
Official Full Name
mitochondrial elongation factor 1provided by MGI
Primary source
MGI:MGI:2146020
See related
Ensembl:ENSMUSG00000022412 AllianceGenome:MGI:2146020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Smcr7l; A230016E22
Summary
Enables identical protein binding activity. Involved in positive regulation of mitochondrial fission. Located in mitochondrion. Orthologous to human MIEF1 (mitochondrial elongation factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 13.4), thymus adult (RPKM 8.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mief1 in Genome Data Viewer
Location:
15 E1; 15 37.85 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (80118284..80137572)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (80233964..80253372)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene mannoside acetylglucosaminyltransferase 3 Neighboring gene STARR-seq mESC enhancer starr_39229 Neighboring gene STARR-seq mESC enhancer starr_39231 Neighboring gene predicted gene, 46521 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene activating transcription factor 4 Neighboring gene ribosomal protein S19 binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of ER-mitochondria contacts using correlative fluorescence microscopy and soft X-ray tomography of mammalian cells. Elgass KD, et al. J Cell Sci, 2015 Aug 1. PMID 26101352, Free PMC Article
  2. Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission. Osellame LD, et al. J Cell Sci, 2016 Jun 1. PMID 27076521, Free PMC Article
  3. The mitochondrial fission receptor MiD51 requires ADP as a cofactor. Losón OC, et al. Structure, 2014 Mar 4. PMID 24508339, Free PMC Article
  4. Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission. Richter V, et al. J Cell Biol, 2014 Feb 17. PMID 24515348, Free PMC Article
  5. ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects. Zhao Y, et al. Nat Commun, 2019 Mar 26. PMID 30914652, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiD51 can suppress Mff-dependent enhancement of Drp1 GTPase activity.
    Title: Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission.
  2. This paper combines confocal live-cell imaging with correlative cryogenic fluorescence microscopy and soft x-ray tomography to link MiD49 and MiD51 to the involvement of the endoplasmic reticulum in mitochondrial fission.
    Title: Analysis of ER-mitochondria contacts using correlative fluorescence microscopy and soft X-ray tomography of mammalian cells.
  3. ADP is an essential cofactor for MiD51 during mitochondrial fission.
    Title: The mitochondrial fission receptor MiD51 requires ADP as a cofactor.
  4. MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and suggest that they provide specificity to the division of mitochondria.
    Title: Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP binding ISO
Inferred from Sequence Orthology
more info
  
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial dynamics protein MID51
Names
Smith-Magenis syndrome chromosome region, candidate 7-like
mitochondrial dynamic protein MID51
mitochondrial dynamic protein of 51 kDa homolog
mitochondrial dynamics protein of 51 kDa homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357659.2 → NP_001344588.1  mitochondrial dynamics protein MID51 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC140267
    Consensus CDS
    CCDS27661.1
    UniProtKB/Swiss-Prot
    Q8BGV8, Q8C4Y9
    UniProtKB/TrEMBL
    B2RPW2
    Related
    ENSMUSP00000154875.2, ENSMUST00000229138.2
    Conserved Domains (1) summary
    pfam03281
    Location:191 → 446
    Mab-21; Mab-21 protein

  2. NM_001357660.2 → NP_001344589.1  mitochondrial dynamics protein MID51 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC140267
    Conserved Domains (1) summary
    pfam03281
    Location:13 → 268
    Mab-21; Mab-21 protein

  3. NM_001416091.1 → NP_001403020.1  mitochondrial dynamics protein MID51 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140267
    UniProtKB/Swiss-Prot
    Q8BGV8, Q8C4Y9
    UniProtKB/TrEMBL
    B2RPW2

  4. NM_001416092.1 → NP_001403021.1  mitochondrial dynamics protein MID51 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140267
    UniProtKB/Swiss-Prot
    Q8BGV8, Q8C4Y9
    UniProtKB/TrEMBL
    B2RPW2

  5. NM_001416093.1 → NP_001403022.1  mitochondrial dynamics protein MID51 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140267
    UniProtKB/Swiss-Prot
    Q8BGV8, Q8C4Y9
    UniProtKB/TrEMBL
    B2RPW2

  6. NM_001416094.1 → NP_001403023.1  mitochondrial dynamics protein MID51 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140267
    UniProtKB/Swiss-Prot
    Q8BGV8, Q8C4Y9
    UniProtKB/TrEMBL
    B2RPW2

  7. NM_001416095.1 → NP_001403024.1  mitochondrial dynamics protein MID51 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140267

  8. NM_001416096.1 → NP_001403025.1  mitochondrial dynamics protein MID51 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140267

  9. NM_001416097.1 → NP_001403026.1  mitochondrial dynamics protein MID51 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140267

  10. NM_178719.6 → NP_848834.2  mitochondrial dynamics protein MID51 isoform 1

    See identical proteins and their annotated locations for NP_848834.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC140267
    Consensus CDS
    CCDS27661.1
    UniProtKB/Swiss-Prot
    Q8BGV8, Q8C4Y9
    UniProtKB/TrEMBL
    B2RPW2
    Related
    ENSMUSP00000023048.5, ENSMUST00000023048.12
    Conserved Domains (1) summary
    pfam03281
    Location:191 → 446
    Mab-21; Mab-21 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    80118284..80137572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGV8.1 GenPept UniProtKB/Swiss-Prot:Q8BGV8

Gene LinkOut

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