Ppm1l protein phosphatase 1 (formerly 2C)-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppm1lprovided by MGI
Official Full Name: protein phosphatase 1 (formerly 2C)-likeprovided by MGI
Primary source: MGI:MGI:2139740
See related: Ensembl:ENSMUSG00000027784 AllianceGenome:MGI:2139740
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PP2C; Pp2ce; Ppp2ce; mKIAA4175; 3222401G13; PP2Cepsilon; 5930404J21Rik
Summary: Enables protein serine/threonine phosphatase activity. Acts upstream of or within MAPK cascade and cell surface receptor protein serine/threonine kinase signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including ganglia; gut; limb segment; metanephros; and sensory organ. Orthologous to human PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cerebellum adult (RPKM 7.4), cortex adult (RPKM 6.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 E1; 3 32.21 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (69224251..69468131)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (69316918..69560798)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study provided evidence that PPM1L is involved in the development of the central nervous system.
Title: Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain.
This study provides the first in vivo evidence that PP2Ce is an essential regulator of normal lactation, possibly involving IRE1 signaling and endoplasmic reticulum stress regulation in mammary epithelium.
Title: IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland.
CERT is a physiological substrate of PP2Cepsilon and that dephosphorylation of CERT by PP2Cepsilon may play an important role in the regulation of ceramide trafficking from the ER to the Golgi apparatus.
Title: Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes.
in the absence of IL-1-induced signal, PP2Cepsilon contributes to keeping the TAK1 signaling pathway in an inactive state by associating with and dephosphorylating TAK1.
Title: Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI481720 (e-PCR)
- UniSTS:165255

48.MMHAP25FRH12.seq (e-PCR)
- UniSTS:159126

AW045850 (e-PCR)
- UniSTS:178846

RH118262 (e-PCR)
- UniSTS:160928

NoName (e-PCR)
- UniSTS:234703

NoName (e-PCR)
- UniSTS:234704

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within MAPK cascade	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein phosphatase 1L

Names: PP2C-epsilon; protein phosphatase 1-like; protein phosphatase 2C epsilon

NP_848841.2

EC 3.1.3.16

XP_006501533.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178726.3 → NP_848841.2 protein phosphatase 1L

See identical proteins and their annotated locations for NP_848841.2

Status: PROVISIONAL

Source sequence(s)

AC111096, AC112685

Consensus CDS

CCDS17405.1

UniProtKB/Swiss-Prot

Q3UGL2, Q810H0, Q8BHN0, Q8C021, Q8C1D5, Q9Z0T1

Related

ENSMUSP00000029355.7, ENSMUST00000029355.9

Conserved Domains (1) summary

cd00143
Location:93 → 351

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

69224251..69468131

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501470.4 → XP_006501533.1 protein phosphatase 1L isoform X1

Conserved Domains (1) summary

cd00143
Location:30 → 246

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...