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Scart1 scavenger receptor family member expressed on T cells 1 [ Mus musculus (house mouse) ]

Gene ID: 244233, updated on 5-Mar-2024

Summary

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Official Symbol
Scart1provided by MGI
Official Full Name
scavenger receptor family member expressed on T cells 1provided by MGI
Primary source
MGI:MGI:2443796
See related
Ensembl:ENSMUSG00000025461 AllianceGenome:MGI:2443796
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd163l1; B430307C05; E430002D04Rik
Summary
Located in plasma membrane. Orthologous to human SCART1 (scavenger receptor family member expressed on T cells 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 1.6), lung adult (RPKM 0.8) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Scart1 in Genome Data Viewer
Location:
7 F4; 7 85.26 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139777131..139811058)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140197218..140231145)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 6 subfamily AE member 1 Neighboring gene STARR-seq mESC enhancer starr_20448 Neighboring gene olfactory receptor enhancer Fourni Neighboring gene olfactory receptor family 6 subfamily F member 2 Neighboring gene olfactory receptor family 6 subfamily B member 13 Neighboring gene scavenger receptor family member expressed on T cells 2 Neighboring gene predicted pseudogene 6314

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Elevated numbers of SCART1+ gammadelta T cells in skin inflammation and inflammatory bowel disease. Fink DR, et al. Mol Immunol, 2010 May. PMID 20381152
  2. Cloning and characterization of SCART1, a novel scavenger receptor cysteine-rich type I transmembrane molecule. Holm D, et al. Mol Immunol, 2009 May. PMID 19297026
  3. SCART scavenger receptors identify a novel subset of adult gammadelta T cells. Kisielow J, et al. J Immunol, 2008 Aug 1. PMID 18641307
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that SCART1 is a novel gammadelta T cell marker and it is therefore likely that SCART1 plays a role in the immune response.
    Title: Elevated numbers of SCART1+ gammadelta T cells in skin inflammation and inflammatory bowel disease.
  2. described two novel surface receptors, SCART1 and SCART2
    Title: SCART scavenger receptors identify a novel subset of adult gammadelta T cells.
  3. mSCART1 is highly related to the WC1 family of the SRCR superfamily.
    Title: Cloning and characterization of SCART1, a novel scavenger receptor cysteine-rich type I transmembrane molecule.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
scavenger receptor cysteine-rich domain-containing protein SCART1
Names
CD163 molecule-like 1
scavenger receptor cysteine-rich type 1 protein CD163c-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172909.4 → NP_766497.3  scavenger receptor cysteine-rich domain-containing protein SCART1 precursor

    See identical proteins and their annotated locations for NP_766497.3

    Status: PROVISIONAL

    Source sequence(s)
    AC107839
    Consensus CDS
    CCDS40174.1
    UniProtKB/TrEMBL
    A0A1B0GSB0, Q8CGY7
    Related
    ENSMUSP00000081497.7, ENSMUST00000084460.7
    Conserved Domains (2) summary
    smart00202
    Location:546 → 646
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:446 → 541
    SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    139777131..139811058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322262.2 → XP_017177751.1  scavenger receptor cysteine-rich domain-containing protein SCART1 isoform X5

    UniProtKB/TrEMBL
    A0A1B0GSB0
    Conserved Domains (2) summary
    smart00202
    Location:430 → 530
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:330 → 425
    SRCR; Scavenger receptor cysteine-rich domain

  2. XM_017322257.2 → XP_017177746.1  scavenger receptor cysteine-rich domain-containing protein SCART1 isoform X1

    UniProtKB/TrEMBL
    A0A1B0GSB0
    Conserved Domains (2) summary
    smart00202
    Location:546 → 646
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:446 → 541
    SRCR; Scavenger receptor cysteine-rich domain

  3. XM_017322258.2 → XP_017177747.1  scavenger receptor cysteine-rich domain-containing protein SCART1 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GSB0, Q8CGY7
    Conserved Domains (2) summary
    smart00202
    Location:546 → 646
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:446 → 541
    SRCR; Scavenger receptor cysteine-rich domain

  4. XM_017322260.2 → XP_017177749.1  scavenger receptor cysteine-rich domain-containing protein SCART1 isoform X4

    UniProtKB/TrEMBL
    A0A1B0GSB0
    Conserved Domains (2) summary
    smart00202
    Location:546 → 646
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:446 → 541
    SRCR; Scavenger receptor cysteine-rich domain

  5. XM_017322259.2 → XP_017177748.1  scavenger receptor cysteine-rich domain-containing protein SCART1 isoform X3

    UniProtKB/TrEMBL
    A0A1B0GSB0
    Conserved Domains (2) summary
    smart00202
    Location:546 → 646
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:446 → 541
    SRCR; Scavenger receptor cysteine-rich domain

  6. XM_017322261.2 → XP_017177750.1  scavenger receptor cysteine-rich domain-containing protein SCART1 isoform X5

    UniProtKB/TrEMBL
    A0A1B0GSB0
    Conserved Domains (2) summary
    smart00202
    Location:430 → 530
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:330 → 425
    SRCR; Scavenger receptor cysteine-rich domain
Nucleotide Protein Strain
Heading Accession and Version

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