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Pkd1l3 polycystic kidney disease 1 like 3 [ Mus musculus (house mouse) ]

Gene ID: 244646, updated on 18-Sep-2024

Summary

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Official Symbol
Pkd1l3provided by MGI
Official Full Name
polycystic kidney disease 1 like 3provided by MGI
Primary source
MGI:MGI:2664670
See related
Ensembl:ENSMUSG00000048827 AllianceGenome:MGI:2664670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Contributes to cation channel activity and sour taste receptor activity. Involved in cation transport; cellular response to acidic pH; and detection of chemical stimulus involved in sensory perception of sour taste. Part of cation channel complex and receptor complex. Colocalizes with cell surface. Is expressed in circumvallate papilla; cochlea; foliate papillae; and testis. Orthologous to human PKD1L3 (polycystin 1 like 3, transient receptor potential channel interacting). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 11.3), lung adult (RPKM 2.7) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Pkd1l3 in Genome Data Viewer
Location:
8 D3; 8 57.14 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110340828..110399305)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (109614190..109672673)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39247 Neighboring gene dihydroorotate dehydrogenase Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112132543-112132726 Neighboring gene increased sodium tolerance 1 homolog (yeast) Neighboring gene STARR-positive B cell enhancer ABC_E3805 Neighboring gene zinc finger protein 821 Neighboring gene predicted gene, 53453 Neighboring gene ataxin 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A PKD1L3 splice variant in taste buds is not cleaved at the G protein-coupled receptor proteolytic site. Kashyap P, et al. Biochem Biophys Res Commun, 2019 May 14. PMID 30928102, Free PMC Article
  2. A proton current drives action potentials in genetically identified sour taste cells. Chang RB, et al. Proc Natl Acad Sci U S A, 2010 Dec 21. PMID 21098668, Free PMC Article
  3. The search for mechanisms underlying the sour taste evoked by acids continues. Dotson CD. Chem Senses, 2010 Sep. PMID 20605873, Free PMC Article
  4. The single pore residue Asp523 in PKD2L1 determines Ca2+ permeation of the PKD1L3/PKD2L1 complex. Fujimoto C, et al. Biochem Biophys Res Commun, 2011 Jan 28. PMID 21185261
  5. Taste function in mice with a targeted mutation of the pkd1l3 gene. Nelson TM, et al. Chem Senses, 2010 Sep. PMID 20605874, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PKD1L3 is cleaved at the N-terminal G protein-coupled receptor proteolytic site.Leucine-708 and Serine-709 are crucial for G protein-coupled receptor proteolytic site cleavage in mouse PKD1L3.
    Title: A PKD1L3 splice variant in taste buds is not cleaved at the G protein-coupled receptor proteolytic site.
  2. These results demonstrate that Asp(523) in PKD2L1 is a key determinant of Ca(2+) permeation into the PKD1L3/PKD2L1 complex and that PKD2L1 contributes to forming the pore of the PKD1L3/PKD2L1 channel.
    Title: The single pore residue Asp523 in PKD2L1 determines Ca2+ permeation of the PKD1L3/PKD2L1 complex.
  3. results suggest that the interaction between PKD1L3 and PKD2L1 through their transmembrane domains is essential for proper trafficking of the channels to the cell surface in taste cells of circumvallate and foliate papillae and in cultured cells
    Title: Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae.
  4. the PKD2L1-PKD1L3 complex is involved in acid sensing in vivo
    Title: Activation of polycystic kidney disease-2-like 1 (PKD2L1)-PKD1L3 complex by acid in mouse taste cells.
  5. PKD1L3-PKD2L1 channel activation by acetic acid was pH-dependent and occurred when the ambient pH was <3.1.
    Title: Acetic acid activates PKD1L3-PKD2L1 channel--a candidate sour taste receptor.
  6. The off-response property of PKD1L3-PKD2L1 channels might explain the physiological phenomena occurring during sour taste sensation.
    Title: Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1.
  7. genes are mapped to chromosomes and gene structures are characterized; protein structure is predicted and contains strong ion channel signature motifs that suggest their possible function as components of cation channel pores
    Title: Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes.
  8. Pkd1l3 and Pkd2l1 are co-expressed in a select subset of taste receptor cells and therefore may, like other PKD channels, function as a heteromer
    Title: Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells.
  9. These results suggest that PKD1L3 and PKD2L1 heteromers may function as sour taste receptors.
    Title: Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to monoatomic cation transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to sour taste receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables sour taste receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to acidic pH IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in cellular response to acidic pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception of sour taste IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in detection of chemical stimulus involved in sensory perception of sour taste IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sensory perception of sour taste ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of cation channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
polycystin-1-like protein 3
Names
PC1-like 3 protein
polycystic kidney disease protein 1-like 3
polycystin-1L3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039700.3 → NP_001034789.2  polycystin-1-like protein 3 isoform a precursor

    See identical proteins and their annotated locations for NP_001034789.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest variant and encodes the longest isoform (a).
    Source sequence(s)
    AC125162
    Consensus CDS
    CCDS40472.1
    UniProtKB/Swiss-Prot
    E9QPA5, Q2EG93, Q2EG94, Q2EG95, Q2EG96, Q2EG97, Q2EG98, Q2EG99, Q7TN87
    Related
    ENSMUSP00000104865.2, ENSMUST00000109242.8
    Conserved Domains (7) summary
    cd00037
    Location:37 → 142
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd01752
    Location:1130 → 1248
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam01825
    Location:1020 → 1058
    GPS; GPCR proteolysis site, GPS, motif
    pfam03546
    Location:208 → 666
    Treacle; Treacher Collins syndrome protein Treacle
    pfam08016
    Location:1708 → 2118
    PKD_channel; Polycystin cation channel
    pfam15229
    Location:345 → 499
    POM121; POM121 family
    pfam15265
    Location:413 → 611
    FAM196; FAM196 family

  2. NM_001286454.2 → NP_001273383.1  polycystin-1-like protein 3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    AC125162
    Consensus CDS
    CCDS85608.1
    UniProtKB/Swiss-Prot
    Q2EG98
    UniProtKB/TrEMBL
    A2A258
    Related
    ENSMUSP00000148592.2, ENSMUST00000212537.2
    Conserved Domains (7) summary
    cd00037
    Location:37 → 142
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd01752
    Location:1120 → 1238
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam01825
    Location:1010 → 1048
    GPS; GPCR proteolysis site, GPS, motif
    pfam03546
    Location:208 → 666
    Treacle; Treacher Collins syndrome protein Treacle
    pfam08016
    Location:1698 → 2108
    PKD_channel; Polycystin cation channel
    pfam15229
    Location:345 → 499
    POM121; POM121 family
    pfam15265
    Location:413 → 611
    FAM196; FAM196 family

  3. NM_181544.3 → NP_853522.2  polycystin-1-like protein 3 isoform b

    See identical proteins and their annotated locations for NP_853522.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a shorter protein (isoform b) that has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC125162
    Consensus CDS
    CCDS22654.1
    UniProtKB/TrEMBL
    A2A258
    Related
    ENSMUSP00000051512.3, ENSMUST00000057344.3
    Conserved Domains (7) summary
    cd00037
    Location:37 → 142
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd01752
    Location:1120 → 1238
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam01825
    Location:1010 → 1048
    GPS; GPCR proteolysis site, GPS, motif
    pfam03546
    Location:208 → 666
    Treacle; Treacher Collins syndrome protein Treacle
    pfam08016
    Location:1698 → 2108
    PKD_channel; Polycystin cation channel
    pfam15229
    Location:345 → 499
    POM121; POM121 family
    pfam15265
    Location:413 → 611
    FAM196; FAM196 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    110340828..110399305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312829.3 → XP_017168318.1  polycystin-1-like protein 3 isoform X8

    Conserved Domains (6) summary
    cd00037
    Location:37 → 142
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    PHA03307
    Location:147 → 513
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01752
    Location:1130 → 1248
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam05109
    Location:351 → 729
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01825
    Location:1020 → 1058
    GPS; GPCR proteolysis site, GPS, motif
    pfam08016
    Location:1708 → 2118
    PKD_channel; Polycystin cation channel

  2. XM_036154041.1 → XP_036009934.1  polycystin-1-like protein 3 isoform X9

    Conserved Domains (6) summary
    cd00037
    Location:37 → 142
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    PHA03307
    Location:147 → 513
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01752
    Location:1151 → 1269
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam05109
    Location:347 → 705
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01825
    Location:1041 → 1079
    GPS; GPCR proteolysis site, GPS, motif
    pfam08016
    Location:1729 → 1909
    PKD_channel; Polycystin cation channel

  3. XM_017312825.3 → XP_017168314.1  polycystin-1-like protein 3 isoform X4

    Conserved Domains (6) summary
    cd00037
    Location:37 → 142
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd01752
    Location:1151 → 1269
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam05109
    Location:325 → 652
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01825
    Location:1041 → 1079
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:137 → 472
    Atrophin-1; Atrophin-1 family
    pfam08016
    Location:1728 → 2138
    PKD_channel; Polycystin cation channel

  4. XM_017312821.3 → XP_017168310.1  polycystin-1-like protein 3 isoform X1

    Conserved Domains (6) summary
    cd00037
    Location:37 → 142
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd01752
    Location:1151 → 1269
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam05109
    Location:325 → 652
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01825
    Location:1041 → 1079
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:137 → 472
    Atrophin-1; Atrophin-1 family
    pfam08016
    Location:1729 → 2139
    PKD_channel; Polycystin cation channel

  5. XM_017312823.3 → XP_017168312.1  polycystin-1-like protein 3 isoform X3

    Conserved Domains (6) summary
    cd00037
    Location:37 → 142
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd01752
    Location:1151 → 1269
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam05109
    Location:325 → 652
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01825
    Location:1041 → 1079
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:137 → 472
    Atrophin-1; Atrophin-1 family
    pfam08016
    Location:1728 → 2138
    PKD_channel; Polycystin cation channel

  6. XM_017312832.3 → XP_017168321.1  polycystin-1-like protein 3 isoform X14

    Conserved Domains (6) summary
    cd00037
    Location:37 → 142
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd01752
    Location:1151 → 1269
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam05109
    Location:325 → 652
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01825
    Location:1041 → 1079
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:137 → 472
    Atrophin-1; Atrophin-1 family
    pfam08016
    Location:1728 → 2138
    PKD_channel; Polycystin cation channel

  7. XM_017312827.3 → XP_017168316.1  polycystin-1-like protein 3 isoform X6

    Conserved Domains (6) summary
    cd00037
    Location:37 → 142
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd01752
    Location:1151 → 1269
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam05109
    Location:325 → 652
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01825
    Location:1041 → 1079
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:137 → 472
    Atrophin-1; Atrophin-1 family
    pfam08016
    Location:1729 → 2139
    PKD_channel; Polycystin cation channel

  8. XM_017312828.3 → XP_017168317.1  polycystin-1-like protein 3 isoform X7

    Conserved Domains (6) summary
    cd00037
    Location:37 → 142
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd01752
    Location:1121 → 1239
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam05109
    Location:325 → 652
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01825
    Location:1011 → 1049
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:137 → 472
    Atrophin-1; Atrophin-1 family
    pfam08016
    Location:1699 → 2109
    PKD_channel; Polycystin cation channel

  9. XM_017312826.3 → XP_017168315.1  polycystin-1-like protein 3 isoform X5

    Conserved Domains (6) summary
    cd00037
    Location:37 → 142
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd01752
    Location:1131 → 1249
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam05109
    Location:325 → 652
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01825
    Location:1021 → 1059
    GPS; GPCR proteolysis site, GPS, motif
    pfam03154
    Location:137 → 472
    Atrophin-1; Atrophin-1 family
    pfam08016
    Location:1709 → 2119
    PKD_channel; Polycystin cation channel

  10. XM_017312822.3 → XP_017168311.1  polycystin-1-like protein 3 isoform X2

    Conserved Domains (6) summary
    cd00037
    Location:37 → 142
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    PHA03307
    Location:147 → 513
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01752
    Location:1150 → 1268
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam05109
    Location:351 → 662
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01825
    Location:1040 → 1078
    GPS; GPCR proteolysis site, GPS, motif
    pfam08016
    Location:1728 → 2138
    PKD_channel; Polycystin cation channel

  11. XM_011248385.4 → XP_011246687.1  polycystin-1-like protein 3 isoform X10

    Conserved Domains (5) summary
    cd00037
    Location:37 → 142
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    PRK07764
    Location:204 → 410
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01752
    Location:1151 → 1269
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam05109
    Location:325 → 652
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01825
    Location:1041 → 1079
    GPS; GPCR proteolysis site, GPS, motif

  12. XM_017312831.3 → XP_017168320.1  polycystin-1-like protein 3 isoform X12

    Conserved Domains (5) summary
    cd00037
    Location:37 → 142
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    PRK07764
    Location:204 → 410
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01752
    Location:1151 → 1269
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam05109
    Location:325 → 652
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01825
    Location:1041 → 1079
    GPS; GPCR proteolysis site, GPS, motif

  13. XM_011248386.4 → XP_011246688.1  polycystin-1-like protein 3 isoform X11

    Conserved Domains (5) summary
    cd00037
    Location:37 → 142
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    PRK07764
    Location:204 → 410
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01752
    Location:1151 → 1269
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam05109
    Location:325 → 652
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01825
    Location:1041 → 1079
    GPS; GPCR proteolysis site, GPS, motif

  14. XM_006531009.5 → XP_006531072.1  polycystin-1-like protein 3 isoform X13

    Conserved Domains (5) summary
    cd00037
    Location:37 → 142
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    PRK07764
    Location:204 → 410
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01752
    Location:1120 → 1238
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam05109
    Location:325 → 652
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01825
    Location:1010 → 1048
    GPS; GPCR proteolysis site, GPS, motif

RNA

  1. XR_003947281.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2EG98.2 GenPept UniProtKB/Swiss-Prot:Q2EG98

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