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Slco2a1 solute carrier organic anion transporter family, member 2a1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24546, updated on 2-Nov-2024

Summary

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Official Symbol
Slco2a1provided by RGD
Official Full Name
solute carrier organic anion transporter family, member 2a1provided by RGD
Primary source
RGD:3051
See related
EnsemblRapid:ENSRNOG00000009005 AllianceGenome:RGD:3051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Matr1; PHOAR2; OATP2A1; Slc21a2
Summary
Predicted to enable prostaglandin transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in prostaglandin transport and sodium-independent organic anion transport. Predicted to be located in basal plasma membrane. Predicted to be active in basolateral plasma membrane. Human ortholog(s) of this gene implicated in primary hypertrophic osteoarthropathy. Orthologous to human SLCO2A1 (solute carrier organic anion transporter family member 2A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 479.9), Liver (RPKM 266.7) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slco2a1 in Genome Data Viewer
Location:
8q32
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (112467739..112551923)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (103588916..103672546)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (111495443..111577320)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene receptor-like tyrosine kinase Neighboring gene uncharacterized LOC102549824 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134480222 Neighboring gene RAB6B, member RAS oncogene family Neighboring gene SRP receptor subunit beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Experimental Evidence for Resecretion of PGE(2) across Rat Alveolar Epithelium by OATP2A1/SLCO2A1-Mediated Transcellular Transport. Nakanishi T, et al. J Pharmacol Exp Ther, 2019 Feb. PMID 30420359
  2. Expression of PGT in MDCK cell monolayers: polarized apical localization and induction of active PG transport. Endo S, et al. Am J Physiol Renal Physiol, 2002 Apr. PMID 11880322
  3. Identification and characterization of a prostaglandin transporter. Kanai N, et al. Science, 1995 May 12. PMID 7754369
  4. Molecular cloning of matrin F/G: A DNA binding protein of the nuclear matrix that contains putative zinc finger motifs. Hakes DJ, et al. Proc Natl Acad Sci U S A, 1991 Jul 15. PMID 2068100, Free PMC Article
  5. Characterization of a major modifier locus for polycystic kidney disease (Modpkdr1) in the Han:SPRD(cy/+) rat in a region conserved with a mouse modifier locus for Alport syndrome. Bihoreau MT, et al. Hum Mol Genet, 2002 Sep 1. PMID 12189169

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OATP2A1 mediates transcellular transport of PGE2 in the apical membrane-to-basolateral direction in alveolar epithelium.
    Title: Experimental Evidence for Resecretion of PGE(2) across Rat Alveolar Epithelium by OATP2A1/SLCO2A1-Mediated Transcellular Transport.
  2. endogenous PGT is exocytically inserted into the collecting duct apical membrane, where it could control the concentration of luminal PGs
    Title: Expression of PGT in MDCK cell monolayers: polarized apical localization and induction of active PG transport.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables prostaglandin transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prostaglandin transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables prostaglandin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in prostaglandin transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prostaglandin transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within prostaglandin transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basal plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier organic anion transporter family member 2A1
Names
PGT
matrin F/G 1
prostaglandin transporter
solute carrier family 21 (prostaglandin transporter), member 2
solute carrier family 21 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022667.4 → NP_073158.2  solute carrier organic anion transporter family member 2A1

    See identical proteins and their annotated locations for NP_073158.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q00910
    UniProtKB/TrEMBL
    A0A0G2JV79, A6I2I3
    Related
    ENSRNOP00000110951.1, ENSRNOT00000168642.1
    Conserved Domains (3) summary
    cd06174
    Location:166 → 425
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:442 → 496
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    TIGR00805
    Location:1 → 630
    oat; sodium-independent organic anion transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    112467739..112551923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243655.4 → XP_006243717.1  solute carrier organic anion transporter family member 2A1 isoform X1

    UniProtKB/Swiss-Prot
    Q00910
    Related
    ENSRNOP00000012162.7, ENSRNOT00000012162.8
    Conserved Domains (2) summary
    cd06174
    Location:67 → 326
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:343 → 397
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

  2. XM_039080798.2 → XP_038936726.1  solute carrier organic anion transporter family member 2A1 isoform X2

    Conserved Domains (1) summary
    cl28910
    Location:1 → 370
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00910.3 GenPept UniProtKB/Swiss-Prot:Q00910

Gene LinkOut

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