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tbx15 T-box transcription factor 15 [ Danio rerio (zebrafish) ]

Gene ID: 246222, updated on 2-Nov-2024

Summary

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Official Symbol
tbx15provided by ZNC
Official Full Name
T-box transcription factor 15provided by ZNC
Primary source
ZFIN:ZDB-GENE-020529-1
See related
Ensembl:ENSDARG00000002582 AllianceGenome:ZFIN:ZDB-GENE-020529-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:63576; zgc:158205
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including cephalic musculature; head mesenchyme; mesenchyme pectoral fin; mesoderm pectoral fin bud; and pharyngeal arch 1. Orthologous to human TBX15 (T-box transcription factor 15). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See tbx15 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (21034870..21067986, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (21224001..21257117, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 3 Neighboring gene uncharacterized LOC137496517 Neighboring gene tryptophanyl tRNA synthetase 2, mitochondrial Neighboring gene hydroxyacid oxidase 2 (long chain)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cloning of zebrafish T-box genes tbx15 and tbx18 and their expression during embryonic development. Begemann G, et al. Mech Dev, 2002 Jun. PMID 12175500
  2. Alternative splicing, phylogenetic analysis, and craniofacial expression of zebrafish tbx22. Jezewski PA, et al. Dev Dyn, 2009 Jun. PMID 19418442, Free PMC Article
  3. Fss/Tbx6 is required for central dermomyotome cell fate in zebrafish. Windner SE, et al. Biol Open, 2012 Aug 15. PMID 23213474, Free PMC Article
  4. Building the vertebrate codex using the gene breaking protein trap library. Ichino N, et al. Elife, 2020 Aug 11. PMID 32779569, Free PMC Article
  5. Genome Sequencing of the Japanese Eel (Anguilla japonica) for Comparative Genomic Studies on tbx4 and a tbx4 Gene Cluster in Teleost Fishes. Chen W, et al. Mar Drugs, 2019 Jul 20. PMID 31330852, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC63576, MGC158205

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelium development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
T-box transcription factor TBX15
Names
T-box 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328433.1 → NP_001315362.1  T-box transcription factor TBX15

    Status: VALIDATED

    Source sequence(s)
    BX255950, EH450697
    UniProtKB/TrEMBL
    A0A2R8QEJ0, A0A8M1P4V6
    Related
    ENSDARP00000152168.1, ENSDART00000180257.1
    Conserved Domains (1) summary
    cd00182
    Location:110 → 305
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    21034870..21067986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478599.2 → XP_021334274.1  T-box transcription factor TBX15 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QAK7
    Conserved Domains (1) summary
    pfam00907
    Location:6 → 195
    T-box

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153664.1: Suppressed sequence

    Description
    NM_153664.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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