onecutl one cut domain, family member, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: onecutlprovided by ZNC
Official Full Name: one cut domain, family member, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020531-1
See related: Ensembl:ENSDARG00000040253 AllianceGenome:ZFIN:ZDB-GENE-020531-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ocl; onecut; onecut1; id:ibd5005
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in nervous system; neural plate; neural rod; and neural tube. Orthologous to human ONECUT1 (one cut homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (29523024..29528129, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (29585345..29593917, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

experiments strongly suggest that hnf-6 and vhnf1 function within an evolutionarily conserved pathway that regulates biliary development
Title: The zebrafish onecut gene hnf-6 functions in an evolutionarily conserved genetic pathway that regulates vertebrate biliary development.
Isolation and expression of a novel neuron-specific onecut homeobox gene; expression was greatly increased in the neural mutant mindbomb, while being decreased in narrowminded.
Title: Isolation and expression of a novel neuron-specific onecut homeobox gene in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: one cut domain, family member, like

Names: one cut domain, family member 1; onecut I; onecut l

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152984.1 → NP_694516.1 one cut domain, family member, like

See identical proteins and their annotated locations for NP_694516.1

Status: PROVISIONAL

Source sequence(s)

AY046954

UniProtKB/TrEMBL

Q8UUX4

Related

ENSDARP00000143806.2, ENSDART00000175376.2

Conserved Domains (2) summary

smart00389
Location:361 → 415

HOX; Homeodomain

pfam02376
Location:264 → 338

CUT; CUT domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

29523024..29528129 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005158041.5 → XP_005158098.1 one cut domain, family member, like isoform X1

UniProtKB/TrEMBL

A0A8M2B4C8, A2BF65

Related

ENSDARP00000124289.1, ENSDART00000150028.2

Conserved Domains (2) summary

smart00389
Location:365 → 419

HOX; Homeodomain

pfam02376
Location:268 → 342

CUT; CUT domain