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ptgs1 prostaglandin-endoperoxide synthase 1 [ Danio rerio (zebrafish) ]

Gene ID: 246226, updated on 2-Nov-2024

Summary

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Official Symbol
ptgs1provided by ZNC
Official Full Name
prostaglandin-endoperoxide synthase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-020530-1
See related
Ensembl:ENSDARG00000052148 AllianceGenome:ZFIN:ZDB-GENE-020530-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cox1; zCOX-1
Summary
Enables peroxidase activity and prostaglandin-endoperoxide synthase activity. Acts upstream of or within several processes, including embryonic liver development; exocrine pancreas development; and vasculogenesis. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasm and neuron projection. Is expressed in several structures, including cardiovascular system; digestive system; eye; mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human PTGS1 (prostaglandin-endoperoxide synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See ptgs1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (64907368..64946436)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (64226204..64265272)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene keratin, type 1, gene c5 Neighboring gene LIM homeobox 6b Neighboring gene uncharacterized LOC101882342 Neighboring gene annexin A1d

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cyclooxygenase-1 as a Potential Therapeutic Target for Seizure Suppression: Evidences from Zebrafish Pentylenetetrazole-Seizure Model. Barbalho PG, et al. Front Neurol, 2016. PMID 27895618, Free PMC Article
  2. The COXes of Danio: from mechanistic model to experimental therapeutics. Prescott SM, et al. Proc Natl Acad Sci U S A, 2002 Jul 9. PMID 12093922, Free PMC Article
  3. LH signaling induced ptgs2a expression is required for ovulation in zebrafish. Tang H, et al. Mol Cell Endocrinol, 2017 May 15. PMID 28254490
  4. Prostaglandins prevent acetaminophen induced embryo toxicity in zebrafish (Danio rerio). Galus M, et al. Environ Toxicol Pharmacol, 2020 Nov. PMID 32822849
  5. The zebrafish genome contains two inducible, functional cyclooxygenase-2 genes. Ishikawa TO, et al. Biochem Biophys Res Commun, 2007 Jan 5. PMID 17112475, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables prostaglandin-endoperoxide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prostaglandin-endoperoxide synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables prostaglandin-endoperoxide synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cyclooxygenase pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within embryonic liver development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within exocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pronephros development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within prostaglandin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prostaglandin G/H synthase 1
Names
Cox-1
Cox-1b
NP_705942.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153656.2 → NP_705942.1  prostaglandin G/H synthase 1 precursor

    See identical proteins and their annotated locations for NP_705942.1

    Status: PROVISIONAL

    Source sequence(s)
    AY028584
    UniProtKB/TrEMBL
    Q8JH44
    Related
    ENSDARP00000104772.2, ENSDART00000122863.3
    Conserved Domains (2) summary
    cd09816
    Location:90 → 576
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    pfam00008
    Location:36 → 68
    EGF; EGF-like domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    64907368..64946436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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