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Pnpla7 patatin-like phospholipase domain containing 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246246, updated on 10-Jul-2024

Summary

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Symbol
Pnpla7provided by RGD
Full Name
patatin-like phospholipase domain containing 7provided by RGD
Primary source
RGD:708466
See related
EnsemblRapid:ENSRNOG00000008190 AllianceGenome:RGD:708466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ntel; Ntel1; Nte-related
Summary
Enables carboxylic ester hydrolase activity. Predicted to be involved in phosphatidylcholine catabolic process. Predicted to be located in endoplasmic reticulum membrane and lipid droplet. Predicted to be active in endoplasmic reticulum. Orthologous to human PNPLA7 (patatin like phospholipase domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 258.8), Thymus (RPKM 158.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pnpla7 in Genome Data Viewer
Location:
3p13
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28180670..28259673)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (7782572..7861504)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2182191..2261890)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene diphthamide biosynthesis 7 Neighboring gene mitochondrial ribosomal protein L41 Neighboring gene glutathione S-transferase pi 1, pseudogene 3 Neighboring gene NMDA receptor synaptonuclear signaling and neuronal migration factor Neighboring gene ectonucleoside triphosphate diphosphohydrolase 8 Neighboring gene NADPH oxidase activator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rat NTE-related esterase is a membrane-associated protein, hydrolyzes phenyl valerate, and interacts with diisopropylfluorophosphate through a serine catalytic machinery. Xie M, et al. Arch Biochem Biophys, 2003 Aug 15. PMID 12893290
  2. Identification of two novel splicing variants of murine NTE-related esterase. Chang PA, et al. Gene, 2012 Apr 15. PMID 22326266
  3. The phospholipase PNPLA7 functions as a lysophosphatidylcholine hydrolase and interacts with lipid droplets through its catalytic domain. Heier C, et al. J Biol Chem, 2017 Nov 17. PMID 28887301, Free PMC Article
  4. Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase. Kienesberger PC, et al. J Biol Chem, 2008 Feb 29. PMID 18086666
  5. Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity. Winrow CJ, et al. Nat Genet, 2003 Apr. PMID 12640454

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108975

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lysophospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophospholipase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysophospholipase activity ISO
Inferred from Sequence Orthology
more info
  
enables lysophospholipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidyl phospholipase B activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylcholine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
patatin-like phospholipase domain-containing protein 7
Names
NTE-related esterase
liver NTE-related protein 1
neuropathy target esterase like 1
patatin-like phospholipase domain-containing protein 7-like
NP_653339.2
XP_038960180.1
XP_038960181.1
XP_038960182.1
XP_038960183.1
XP_038960184.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144738.2 → NP_653339.2  patatin-like phospholipase domain-containing protein 7

    See identical proteins and their annotated locations for NP_653339.2

    Status: VALIDATED

    Source sequence(s)
    BC083547, BC091230, DN934725
    UniProtKB/Swiss-Prot
    Q5BK26, Q5XIX2, Q8K3H9
    UniProtKB/TrEMBL
    A6JT00, G3V745
    Related
    ENSRNOP00000011633.5, ENSRNOT00000011633.7
    Conserved Domains (4) summary
    cd07225
    Location:930 → 1235
    Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
    COG0664
    Location:164 → 306
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    COG1752
    Location:935 → 1221
    RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]
    cd00038
    Location:601 → 709
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    28180670..28259673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104252.2 → XP_038960180.1  patatin-like phospholipase domain-containing protein 7 isoform X1

    Related
    ENSRNOP00000112741.1, ENSRNOT00000141487.1
    Conserved Domains (2) summary
    cd00038
    Location:601 → 709
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cl11396
    Location:930 → 955
    Patatin_and_cPLA2; Patatins and Phospholipases

  2. XM_039104253.2 → XP_038960181.1  patatin-like phospholipase domain-containing protein 7 isoform X2

    Conserved Domains (1) summary
    cd00038
    Location:601 → 709
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  3. XM_039104254.2 → XP_038960182.1  patatin-like phospholipase domain-containing protein 7 isoform X3

    Conserved Domains (1) summary
    cd00038
    Location:601 → 709
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  4. XM_039104255.2 → XP_038960183.1  patatin-like phospholipase domain-containing protein 7 isoform X4

    Conserved Domains (2) summary
    cd07225
    Location:349 → 654
    Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
    cd00038
    Location:20 → 128
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  5. XM_039104256.2 → XP_038960184.1  patatin-like phospholipase domain-containing protein 7 isoform X5

    Conserved Domains (1) summary
    cd07225
    Location:263 → 568
    Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7

RNA

  1. XR_005501774.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BK26.2 GenPept UniProtKB/Swiss-Prot:Q5BK26

Gene LinkOut

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