Zfp386 zinc finger protein 386 (Kruppel-like) [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp386provided by RGD
Official Full Name: zinc finger protein 386 (Kruppel-like)provided by RGD
Primary source: RGD:2985
See related: EnsemblRapid:ENSRNOG00000004268 AllianceGenome:RGD:2985
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kzf1; Znf386
Summary: Enables DNA binding activity. Involved in negative regulation of transcription involved in meiotic cell cycle and spermatogenesis. Predicted to be active in nucleus. Orthologous to human ZNF519 (zinc finger protein 519). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 123.0), Adrenal (RPKM 121.7) and 9 other tissues See more
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Genomic context

Location:: 6q33

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (143109563..143124266)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (136966547..136984013)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (143901239..143915953)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 386 (Kruppel-like)

Names: Kruppel associated box (KRAB) zinc finger 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019620.3 → NP_062566.3 zinc finger protein 386 (Kruppel-like)

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

Q6AYY1

Related

ENSRNOP00000070717.3, ENSRNOT00000091884.3

Conserved Domains (4) summary

COG5048
Location:424 → 584

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:456 → 476

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:6 → 45

KRAB; KRAB box

pfam13465
Location:384 → 409

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

143109563..143124266

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111798.2 → XP_038967726.1 zinc finger protein 386 (Kruppel-like) isoform X3

Conserved Domains (1) summary

smart00349
Location:6 → 47

KRAB; krueppel associated box
XM_039111799.2 → XP_038967727.1 zinc finger protein 386 (Kruppel-like) isoform X4

Conserved Domains (1) summary

smart00349
Location:6 → 49

KRAB; krueppel associated box
XM_063261557.1 → XP_063117627.1 zinc finger protein 386 (Kruppel-like) isoform X1
XM_063261558.1 → XP_063117628.1 zinc finger protein 386 (Kruppel-like) isoform X2
XM_039111797.2 → XP_038967725.1 zinc finger protein 386 (Kruppel-like) isoform X2

Conserved Domains (3) summary

COG5048
Location:327 → 487

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:359 → 379

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:287 → 312

zf-H2C2_2; Zinc-finger double domain