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Adam34 a disintegrin and metallopeptidase domain 34 [ Mus musculus (house mouse) ]

Gene ID: 252866, updated on 9-Dec-2024

Summary

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Official Symbol
Adam34provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 34provided by MGI
Primary source
MGI:MGI:2181992
See related
Ensembl:ENSMUSG00000079058 AllianceGenome:MGI:2181992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. Is expressed in seminiferous tubule and testis. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward testis adult (RPKM 4.6) See more
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Genomic context

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See Adam34 in Genome Data Viewer
Location:
8 A4; 8 24.07 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (44103346..44118597, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (43650309..43665560, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 26A Neighboring gene STARR-seq mESC enhancer starr_21335 Neighboring gene STARR-seq mESC enhancer starr_21336 Neighboring gene a disintegrin and metallopeptidase domain 26B pseudogene Neighboring gene a disintegrin and metallopeptidase domain 34 like Neighboring gene predicted gene 5347 Neighboring gene predicted gene 45488 Neighboring gene STARR-seq mESC enhancer starr_21337 Neighboring gene WW domain binding protein 11 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression analysis of a novel member of the Disintegrin and Metalloprotease-Domain (ADAM) family. Brachvogel B, et al. Gene, 2002 Apr 17. PMID 12034510
  2. A family of cellular proteins related to snake venom disintegrins. Weskamp G, et al. Proc Natl Acad Sci U S A, 1994 Mar 29. PMID 8146185, Free PMC Article
  3. Human and mouse proteases: a comparative genomic approach. Puente XS, et al. Nat Rev Genet, 2003 Jul. PMID 12838346
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sperm head plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
a disintegrin and metallopeptidase domain 34
Names
testase 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145745.3 → NP_665688.2  a disintegrin and metallopeptidase domain 34

    See identical proteins and their annotated locations for NP_665688.2

    Status: VALIDATED

    Source sequence(s)
    AC131115, BC141203
    Consensus CDS
    CCDS22271.1
    UniProtKB/TrEMBL
    A2RSG8, Q8K4K0
    Related
    ENSMUSP00000148332.2, ENSMUST00000212185.2
    Conserved Domains (4) summary
    smart00608
    Location:492 → 628
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:207 → 395
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:416 → 488
    Disintegrin
    pfam01562
    Location:41 → 159
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    44103346..44118597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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