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Cdk11b cyclin-dependent kinase 11B [ Rattus norvegicus (Norway rat) ]

Gene ID: 252879, updated on 17-Aug-2024

Summary

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Official Symbol
Cdk11bprovided by RGD
Official Full Name
cyclin-dependent kinase 11Bprovided by RGD
Primary source
RGD:628604
See related
EnsemblRapid:ENSRNOG00000017213 AllianceGenome:RGD:628604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cdk11; Cdc2l1
Summary
Predicted to enable ATP binding activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in several processes, including protein phosphorylation; regulation of cell growth; and regulation of mRNA processing. Predicted to act upstream of or within blastocyst development; negative regulation of apoptotic signaling pathway; and regulation of mitotic nuclear division. Predicted to be located in nuclear membrane and perinuclear region of cytoplasm. Predicted to be active in nucleus. Orthologous to several human genes including CDK11B (cyclin dependent kinase 11B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 80.7), Spleen (RPKM 77.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdk11b in Genome Data Viewer
Location:
5q36
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171495042..171521143)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166212761..166238883)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173051900..173078049)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487048 Neighboring gene solute carrier family 35, member E2B Neighboring gene ribosomal protein L27A like 10 Neighboring gene matrix metallopeptidase 23 Neighboring gene MIB E3 ubiquitin protein ligase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of the synthesis and expression of the GTA-kinase from transformed and normal rodent cells. Kerr M, et al. Biochim Biophys Acta, 1994 Aug 2. PMID 8049264
  2. LPS-stimulating astrocyte-conditioned medium causes neuronal apoptosis via increasing CDK11(p58) expression in PC12 cells through downregulating AKT pathway. Liu X, et al. Cell Mol Neurobiol, 2013 Aug. PMID 23703121
  3. Protein expression pattern of CDK11(p58) during testicular development in the mouse. Niu Z, et al. Mol Cell Biochem, 2005 Feb. PMID 15792358
  4. Failure to proliferate and mitotic arrest of CDK11(p110/p58)-null mutant mice at the blastocyst stage of embryonic cell development. Li T, et al. Mol Cell Biol, 2004 Apr. PMID 15060143, Free PMC Article
  5. The functional interaction between CDK11p58 and β-1,4-galactosyltransferase I involved in astrocyte activation caused by lipopolysaccharide. Liu X, et al. Inflammation, 2012 Aug. PMID 22527143

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AKT signaling pathway is involved in CDK11(p58)-induced neuronal apoptosis process.
    Title: LPS-stimulating astrocyte-conditioned medium causes neuronal apoptosis via increasing CDK11(p58) expression in PC12 cells through downregulating AKT pathway.
  2. These findings indicated that the functional interaction between CDK11(p58) and beta-1,4-GalT-I may play an important role during astrocyte activation after LPS administration.
    Title: The functional interaction between CDK11p58 and β-1,4-galactosyltransferase I involved in astrocyte activation caused by lipopolysaccharide.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in blastocyst development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within blastocyst development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 11B
Names
PITSLRE serine/threonine-protein kinase CDC2L1
cell division cycle 2 homolog-like 1
cell division cycle 2-like protein kinase 1
cell division protein kinase 11
cyclin-dependent kinase 11
galactosyltransferase-associated protein kinase p58/GTA
NP_665709.2
XP_006239591.1
XP_006239592.1
XP_006239593.1
XP_038965218.1
XP_038965221.1
XP_038965222.1
XP_038965223.1
XP_063143248.1
XP_063143249.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145766.2 → NP_665709.2  cyclin-dependent kinase 11B

    See identical proteins and their annotated locations for NP_665709.2

    Status: VALIDATED

    Source sequence(s)
    AA817907, DY544650, DY556124, EX490221, FM031851, FM044847
    UniProtKB/TrEMBL
    D4A3G2
    Related
    ENSRNOP00000023274.6, ENSRNOT00000023274.8
    Conserved Domains (1) summary
    cd07843
    Location:421 → 712
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    171495042..171521143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239531.5 → XP_006239593.1  cyclin-dependent kinase 11B isoform X3

    See identical proteins and their annotated locations for XP_006239593.1

    UniProtKB/TrEMBL
    D3ZML3
    Conserved Domains (2) summary
    cd07843
    Location:387 → 678
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:390 → 680
    PLN00009; cyclin-dependent kinase A; Provisional

  2. XM_063287179.1 → XP_063143249.1  cyclin-dependent kinase 11B isoform X4

  3. XM_006239530.4 → XP_006239592.1  cyclin-dependent kinase 11B isoform X3

    See identical proteins and their annotated locations for XP_006239592.1

    UniProtKB/TrEMBL
    D3ZML3
    Conserved Domains (2) summary
    cd07843
    Location:387 → 678
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:390 → 680
    PLN00009; cyclin-dependent kinase A; Provisional

  4. XM_063287178.1 → XP_063143248.1  cyclin-dependent kinase 11B isoform X1

  5. XM_039109290.2 → XP_038965218.1  cyclin-dependent kinase 11B isoform X2

    UniProtKB/TrEMBL
    A6IUR2
    Conserved Domains (1) summary
    cd07843
    Location:420 → 711
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  6. XM_006239529.5 → XP_006239591.1  cyclin-dependent kinase 11B isoform X3

    See identical proteins and their annotated locations for XP_006239591.1

    UniProtKB/TrEMBL
    D3ZML3
    Related
    ENSRNOP00000039105.5, ENSRNOT00000050188.6
    Conserved Domains (2) summary
    cd07843
    Location:387 → 678
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:390 → 680
    PLN00009; cyclin-dependent kinase A; Provisional

  7. XM_039109294.2 → XP_038965222.1  cyclin-dependent kinase 11B isoform X6

    Conserved Domains (1) summary
    cd07843
    Location:204 → 495
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  8. XM_039109293.2 → XP_038965221.1  cyclin-dependent kinase 11B isoform X5

    Conserved Domains (1) summary
    cd07843
    Location:225 → 516
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  9. XM_039109295.2 → XP_038965223.1  cyclin-dependent kinase 11B isoform X7

    UniProtKB/Swiss-Prot
    P46892
    Related
    ENSRNOP00000100557.1, ENSRNOT00000160153.1
    Conserved Domains (1) summary
    cd07843
    Location:76 → 367
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46892.1 GenPept UniProtKB/Swiss-Prot:P46892

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Chemical Information
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Research Materials