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Acox2 acyl-CoA oxidase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 252898, updated on 18-Sep-2024

Summary

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Official Symbol
Acox2provided by RGD
Official Full Name
acyl-CoA oxidase 2provided by RGD
Primary source
RGD:628684
See related
EnsemblRapid:ENSRNOG00000007378 AllianceGenome:RGD:628684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
THCCox
Summary
Enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Involved in fatty acid beta-oxidation. Located in peroxisome. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 6. Orthologous to human ACOX2 (acyl-CoA oxidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 982.6) See more
Orthologs
human mouse all
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Genomic context

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See Acox2 in Genome Data Viewer
Location:
15p14
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (19090820..19122392)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (16660584..16692160)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (18449304..18481472)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096928 Neighboring gene family with sequence similarity 107, member A Neighboring gene uncharacterized LOC120096930 Neighboring gene potassium channel tetramerization domain containing 6 Neighboring gene heat shock protein family E (Hsp10) member 1, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Three-dimensional structure of rat-liver acyl-CoA oxidase in complex with a fatty acid: insights into substrate-recognition and reactivity toward molecular oxygen. Tokuoka K, et al. J Biochem, 2006 Apr. PMID 16672280
  2. Molecular cloning and further characterization of rat peroxisomal trihydroxycoprostanoyl-CoA oxidase. Baumgart E, et al. Biochem J, 1996 Nov 15. PMID 8947475, Free PMC Article
  3. ACOX2 deficiency: An inborn error of bile acid synthesis identified in an adolescent with persistent hypertransaminasemia. Monte MJ, et al. J Hepatol, 2017 Mar. PMID 27884763
  4. Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters: stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase. Van Veldhoven PP, et al. FEBS Lett, 1996 Jun 10. PMID 8654595
  5. Separate peroxisomal oxidases for fatty acyl-CoAs and trihydroxycoprostanoyl-CoA in human liver. Casteels M, et al. J Lipid Res, 1990 Oct. PMID 2079609

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The overall dimeric structure and the folding pattern of each subunit are essentially superimposable on those of uncomplexed acyl-CoA oxidase-II structure.
    Title: Three-dimensional structure of rat-liver acyl-CoA oxidase in complex with a fatty acid: insights into substrate-recognition and reactivity toward molecular oxygen.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables acyl-CoA oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables fatty acid binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables palmitoyl-CoA oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in bile acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in bile acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fatty acid beta-oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA oxidase IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA oxidase ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in very long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxisomal acyl-coenzyme A oxidase 2
Names
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase
THCA-CoA oxidase
acyl-CoA oxidase 2, branched chain
acyl-Coenzyme A oxidase 2, branched chain
trihydroxycoprostanoyl-CoA oxidase
NP_665713.2
XP_006251805.2
XP_006251806.1
XP_038948932.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145770.4 → NP_665713.2  peroxisomal acyl-coenzyme A oxidase 2

    See identical proteins and their annotated locations for NP_665713.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    P97562
    UniProtKB/TrEMBL
    F1LNW3
    Related
    ENSRNOP00000010260.3, ENSRNOT00000010260.6
    Conserved Domains (1) summary
    cd01150
    Location:20 → 655
    AXO; Peroxisomal acyl-CoA oxidase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    19090820..19122392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251744.4 → XP_006251806.1  peroxisomal acyl-coenzyme A oxidase 2 isoform X1

    See identical proteins and their annotated locations for XP_006251806.1

    UniProtKB/Swiss-Prot
    P97562
    UniProtKB/TrEMBL
    F1LNW3
    Conserved Domains (1) summary
    cd01150
    Location:20 → 655
    AXO; Peroxisomal acyl-CoA oxidase

  2. XM_006251743.4 → XP_006251805.2  peroxisomal acyl-coenzyme A oxidase 2 isoform X1

    UniProtKB/Swiss-Prot
    P97562
    UniProtKB/TrEMBL
    F1LNW3
    Conserved Domains (1) summary
    cd01150
    Location:20 → 655
    AXO; Peroxisomal acyl-CoA oxidase

  3. XM_039093004.2 → XP_038948932.1  peroxisomal acyl-coenzyme A oxidase 2 isoform X1

    UniProtKB/Swiss-Prot
    P97562
    UniProtKB/TrEMBL
    F1LNW3
    Conserved Domains (1) summary
    cd01150
    Location:20 → 655
    AXO; Peroxisomal acyl-CoA oxidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97562.1 GenPept UniProtKB/Swiss-Prot:P97562

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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