Ms4a2 membrane spanning 4-domains A2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ms4a2provided by RGD
Official Full Name: membrane spanning 4-domains A2provided by RGD
Primary source: RGD:2598
See related: EnsemblRapid:ENSRNOG00000020993 AllianceGenome:RGD:2598
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: FCIGA; Ms4a1; Fcer1b
Summary: Enables SH2 domain binding activity; phosphoprotein binding activity; and protein kinase binding activity. Involved in positive regulation of mast cell degranulation and regulation of release of sequestered calcium ion into cytosol. Located in endosome. Human ortholog(s) of this gene implicated in asthma; atopic dermatitis; and rhinitis. Orthologous to human MS4A2 (membrane spanning 4-domains A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 10.6), Muscle (RPKM 9.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (217864855..217873934, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (208440179..208448716, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (227957363..227965312, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family
Title: Cross-talk between tetraspanin CD9 and transmembrane adaptor protein non-T cell activation linker (NTAL) in mast cell activation and chemotaxis.
PLSCR1 is a novel amplifier of FcepsilonRI signaling that acts selectively on the Lyn-initiated LAT/phospholipase Cgamma1/calcium axis, resulting in potentiation of a selected set of mast cell responses
Title: Phospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathway.
analysis of molecular dynamics associated with IgE receptor cross-linking in mast cells
Title: Membrane order and molecular dynamics associated with IgE receptor cross-linking in mast cells.
Constitutive interaction between the unique domain of Fc epsilon RI beta subunit and Lyn kinase is a crucial step in the initiation of Fc epsilon RI signaling during mast cell secretion
Title: Regulation of rat basophilic leukemia-2H3 mast cell secretion by a constitutive Lyn kinase interaction with the high affinity IgE receptor (Fc epsilon RI).
membrane-spanning 4-domains, subfamily A, member 2 pathway?
Title: Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94404 (e-PCR)
- UniSTS:119652

D1Bda55 (e-PCR)
- UniSTS:239808

Ms4a2 (e-PCR), detects polymorphism
- UniSTS:527043

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables IgE binding	IEA Inferred from Electronic Annotation more info
contributes_to IgE binding	ISO Inferred from Sequence Orthology more info
enables SH2 domain binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of release of sequestered calcium ion into cytosol	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Fc-epsilon receptor I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Fc-epsilon receptor I complex	IEA Inferred from Electronic Annotation more info
part_of Fc-epsilon receptor I complex	ISO Inferred from Sequence Orthology more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: high affinity immunoglobulin epsilon receptor subunit beta

Names: IgE Fc receptor subunit beta; Membrane-spanning 4-domains, subfamily A, member 1; beta polypeptide); fc epsilon receptor I beta-chain; fcERI; membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012845.1 → NP_036977.1 high affinity immunoglobulin epsilon receptor subunit beta

See identical proteins and their annotated locations for NP_036977.1

Status: VALIDATED

Source sequence(s)

M22923

UniProtKB/Swiss-Prot

P13386

UniProtKB/TrEMBL

A0A0H2UHS6, A6I0A1

Related

ENSRNOP00000028491.3, ENSRNOT00000028491.5

Conserved Domains (1) summary

pfam04103
Location:60 → 200

CD20; CD20-like family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

217864855..217873934 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101547.2 → XP_038957475.1 high affinity immunoglobulin epsilon receptor subunit beta isoform X1

Conserved Domains (1) summary

pfam04103
Location:129 → 250

CD20; CD20-like family