U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mak3 phosphorelay sensor kinase Mak3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539117, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
mak3
Official Full Name
phosphorelay sensor kinase Mak3
Primary source
PomBase:SPCC74.06
Locus tag
SPOM_SPCC74.06
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
phk2
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mak3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (1940315..1947736)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene gamma-aminobutyric acid/polyamine transporter Neighboring gene ncRNA Neighboring gene 60S ribosomal protein eL27 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene beta-glucosidase Adg3

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic analysis of the His-to-Asp phosphorelay implicated in mitotic cell cycle control: involvement of histidine-kinase genes of Schizosaccharomyces pombe. Aoyama K, et al. Biosci Biotechnol Biochem, 2001 Oct. PMID 11758939
  2. Stress sensitivity of a fission yeast strain lacking histidine kinases is rescued by the ectopic expression of Chk1 from Candida albicans. Maksimov V, et al. Curr Genet, 2017 May. PMID 27613427, Free PMC Article
  3. Two-component mediated peroxide sensing and signal transduction in fission yeast. Quinn J, et al. Antioxid Redox Signal, 2011 Jul 1. PMID 20919928
  4. Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway. Buck V, et al. Mol Biol Cell, 2001 Feb. PMID 11179424, Free PMC Article
  5. Functional characterization of the phosphorelay protein Mpr1p from Schizosaccharomyces pombe. Tan H, et al. FEMS Yeast Res, 2007 Sep. PMID 17559414

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate distinct functions for the three histidine kinases; Mak1 alone or Mak2 and Mak3 together were sufficient for the repression of the meiotic cycle when nutrients were available.
    Title: Stress sensitivity of a fission yeast strain lacking histidine kinases is rescued by the ectopic expression of Chk1 from Candida albicans.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay sensor kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables phosphorelay sensor kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphorelay signal transduction system IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of p38MAPK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of p38MAPK cascade IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm HDA PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
part_of protein histidine kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
phosphorelay sensor kinase Mak3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1940315..1947736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023370.3 → NP_588379.1  phosphorelay sensor kinase Mak3 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588379.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74539
    Conserved Domains (9) summary
    smart00387
    Location:1898 → 2002
    HATPase_c; Histidine kinase-like ATPases
    smart00388
    Location:1786 → 1850
    HisKA; His Kinase A (phosphoacceptor) domain
    COG0515
    Location:49 → 306
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    COG2203
    Location:1474 → 1636
    FhlA; GAF domain [Signal transduction mechanisms]
    COG3899
    Location:388 → 1397
    COG3899; Predicted ATPase [General function prediction only]
    cd00130
    Location:1702 → 1769
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    cd00156
    Location:2213 → 2333
    REC; Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; ...
    pfam00989
    Location:1658 → 1769
    PAS; PAS fold
    cl21453
    Location:122 → 293
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials