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top3 DNA topoisomerase III [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539881, updated on 18-Sep-2024

Summary

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Official Symbol
top3
Official Full Name
DNA topoisomerase III
Primary source
PomBase:SPBC16G5.12c
Locus tag
SPOM_SPBC16G5.12C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See top3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003423.3 (4233868..4236269, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene serine carboxypeptidase Neighboring gene ncRNA Neighboring gene exosome subunit Rrp42 Neighboring gene ncRNA Neighboring gene BAG family molecular chaperone regulator Bag101 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein ptf2 Neighboring gene 40S ribosomal protein uS3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Topoisomerase III is essential for accurate nuclear division in Schizosaccharomyces pombe. Goodwin A, et al. Nucleic Acids Res, 1999 Oct 15. PMID 10497270, Free PMC Article
  2. The top3(+) gene is essential in Schizosaccharomyces pombe and the lethality associated with its loss is caused by Rad12 helicase activity. Maftahi M, et al. Nucleic Acids Res, 1999 Dec 15. PMID 10572171, Free PMC Article
  3. Topoisomerase III is required for accurate DNA replication and chromosome segregation in Schizosaccharomyces pombe. Oh M, et al. Nucleic Acids Res, 2002 Sep 15. PMID 12235386, Free PMC Article
  4. The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function. Ahmad F, et al. Mol Genet Genomics, 2005 Mar. PMID 15702347
  5. Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrity. Win TZ, et al. J Cell Sci, 2004 Sep 15. PMID 15340008

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA binding ISM
Inferred from Sequence Model
more info
  
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA topological change IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homologous recombination EXP
Inferred from Experiment
more info
 PubMed 
involved_in mitotic DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postreplication repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in recombination within rDNA repeats EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
part_of RecQ family helicase-topoisomerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RecQ family helicase-topoisomerase III complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA topoisomerase III

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    4233868..4236269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023781.3 → NP_596761.1  DNA topoisomerase III [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596761.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O60126
    Conserved Domains (3) summary
    cd03362
    Location:2 → 162
    TOPRIM_TopoIA_TopoIII; TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving ...
    COG0550
    Location:3 → 615
    TopA; DNA topoisomerase IA [Replication, recombination and repair]
    cd00186
    Location:168 → 596
    TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
Nucleotide Protein
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