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lam2 guanyl-nucleotide exchange factor Lam2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540131, updated on 18-Sep-2024

Summary

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Official Symbol
lam2
Official Full Name
guanyl-nucleotide exchange factor Lam2
Primary source
PomBase:SPBC1778.05c
Locus tag
SPOM_SPBC1778.05C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See lam2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (3102902..3105786, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene telomere-binding protein Rap1 Neighboring gene NADH pyrophosphatase Neighboring gene Spo4-Spo6 kinase complex regulatory subunit Spo6 Neighboring gene ncRNA Neighboring gene fimbrin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast. Ma N, et al. PLoS One, 2016. PMID 27227887, Free PMC Article
  2. Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases. Chia KH, et al. Elife, 2017 Dec 4. PMID 29199950, Free PMC Article
  3. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article
  4. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Stewart EV, et al. Mol Cell, 2011 Apr 22. PMID 21504829, Free PMC Article
  5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-membrane adaptor activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to amino acid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ragulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ragulator complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of Ragulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
guanyl-nucleotide exchange factor Lam2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3102902..3105786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022210.3 → NP_596288.2  guanyl-nucleotide exchange factor Lam2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596288.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9Y7J2
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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