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sip1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540316, updated on 11-Sep-2024

Summary

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Official Symbol
sip1
Primary source
PomBase:SPBC27B12.08
Locus tag
SPOM_SPBC27B12.08
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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Location:
chromosome: II
Exon count:
10
Sequence:
Chromosome: II; NC_003423.3 (1335711..1344204)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene WD repeat protein Crt10, involved in ribosomal RNA decay Neighboring gene uncharacterized protein Neighboring gene pig-O family ethanolamine phosphate transferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene FAD transporter Neighboring gene mitochondrial TOM complex subunit Tom7 Neighboring gene transcription factor Pho1 Neighboring gene protein Cbp4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a conserved F-box protein 6 interactor essential for endocytosis and cytokinesis in fission yeast. Jourdain I, et al. Biochem J, 2009 May 13. PMID 19243310, Free PMC Article
  2. Sip1, an AP-1 accessory protein in fission yeast, is required for localization of Rho3 GTPase. Yu Y, et al. PLoS One, 2013. PMID 23840894, Free PMC Article
  3. Sip1, a conserved AP-1 accessory protein, is important for Golgi/endosome trafficking in fission yeast. Yu Y, et al. PLoS One, 2012. PMID 23028933, Free PMC Article
  4. The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components. Salas-Pino S, et al. J Cell Biol, 2017 Nov 6. PMID 28974540, Free PMC Article
  5. Promoter nucleosome dynamics regulated by signalling through the CTD code. Materne P, et al. Elife, 2015 Jun 22. PMID 26098123, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sip1 recruits Rho3 to the Golgi/endosomes through physical interaction and enhances the formation of the Golgi/endosome AP-1/Rho3 complex, thereby promoting crosstalk between AP-1 and Rho3 in the regulation of Golgi/endosomal trafficking in fission yeast.
    Title: Sip1, an AP-1 accessory protein in fission yeast, is required for localization of Rho3 GTPase.
  2. Findings reveal a role for Sip1 in the regulation of Golgi/endosome trafficking in coordination with the AP-1 complex, and identified Bgs1, required for cell wall synthesis, as the new cargo of AP-1-dependent trafficking.
    Title: Sip1, a conserved AP-1 accessory protein, is important for Golgi/endosome trafficking in fission yeast.
  3. Study identified a novel conserved protein, Sip1, as an interacting partner of an essential F-box protein Pof6.
    Title: Identification of a conserved F-box protein 6 interactor essential for endocytosis and cytokinesis in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IC
Inferred by Curator
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus HDA PubMed 
is_active_in cytosol HDA PubMed 
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Pof6-interacting protein Sip1 AP-1 accessory protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    1335711..1344204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356216.2 → NP_001342706.1  Pof6-interacting protein Sip1 AP-1 accessory protein [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13661, O42998
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials