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thi4 bifunctional thiamine-phosphate dipyrophosphorylase/hydroxyethylthiazole kinase [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541872, updated on 18-Sep-2024

Summary

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Official Symbol
thi4
Official Full Name
bifunctional thiamine-phosphate dipyrophosphorylase/hydroxyethylthiazole kinase
Primary source
PomBase:SPAC23H4.10c
Locus tag
SPOM_SPAC23H4.10C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See thi4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (1589933..1593248)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Clr6 histone deacetylase complex, chromodomain subunit Alp13/Eaf3 Neighboring gene ncRNA Neighboring gene centromere localized protein Cnl2 Neighboring gene ncRNA Neighboring gene peptidase family curved DNA-binding protein Cdb4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA polymerase II nuclear import protein Iwr1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability. Calvo IA, et al. iScience, 2021 Nov 19. PMID 34805795, Free PMC Article
  2. Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions. Nie M, et al. J Biol Chem, 2012 Aug 24. PMID 22730331, Free PMC Article
  3. A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast. Mathiassen SG, et al. J Biol Chem, 2015 Aug 21. PMID 26152728, Free PMC Article
  4. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Roguev A, et al. Science, 2008 Oct 17. PMID 18818364, Free PMC Article
  5. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydroxyethylthiazole kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables thiamine-phosphate diphosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in thiamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thiamine diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 

General protein information

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Preferred Names
bifunctional thiamine-phosphate dipyrophosphorylase/hydroxyethylthiazole kinase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1589933..1593248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018828.3 → NP_593396.1  bifunctional thiamine-phosphate dipyrophosphorylase/hydroxyethylthiazole kinase [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593396.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P40386
    Conserved Domains (2) summary
    TIGR00694
    Location:246 → 503
    thiM; hydroxyethylthiazole kinase
    COG0352
    Location:4 → 220
    ThiE; Thiamine monophosphate synthase [Coenzyme transport and metabolism]
Nucleotide Protein
Heading Accession and Version

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