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dmc1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542106, updated on 11-Sep-2024

Summary

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Official Symbol
dmc1
Primary source
PomBase:SPAC8E11.03c
Locus tag
SPOM_SPAC8E11.03C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
dmp1
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Genomic context

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Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003424.3 (3382264..3383404)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene palmitoyl-(protein) hydrolase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 14-3-3 protein Rad24 Neighboring gene ncRNA Neighboring gene beta-fructofuranosidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dmc1 of Schizosaccharomyces pombe plays a role in meiotic recombination. Fukushima K, et al. Nucleic Acids Res, 2000 Jul 15. PMID 10908327, Free PMC Article
  2. Functional interactions of meiotic recombination factors Rdh54 and Dmc1. Chi P, et al. DNA Repair (Amst), 2009 Feb 1. PMID 19028606, Free PMC Article
  3. Crossover invariance determined by partner choice for meiotic DNA break repair. Hyppa RW, et al. Cell, 2010 Jul 23. PMID 20655467, Free PMC Article
  4. The Swi5-Sfr1 complex stimulates Rhp51/Rad51- and Dmc1-mediated DNA strand exchange in vitro. Haruta N, et al. Nat Struct Mol Biol, 2006 Sep. PMID 16921379
  5. Fission yeast rad51 and dmc1, two efficient DNA recombinases forming helical nucleoprotein filaments. Sauvageau S, et al. Mol Cell Biol, 2005 Jun. PMID 15899844, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hop2-Mnd1 and Swi5-Sfr1 stimulate Dmc1 filament assembly using distinct mechanisms.
    Title: Hop2-Mnd1 and Swi5-Sfr1 stimulate Dmc1 filament assembly using distinct mechanisms.
  2. the Swi5-Sfr1 complex from fission yeast is both a mediator that loads Dmc1 onto ssDNA and a direct "activator" of DNA strand exchange by Dmc1
    Title: Dual regulation of Dmc1-driven DNA strand exchange by Swi5-Sfr1 activation and Rad22 inhibition.
  3. Complex formation between Rdh54 and Dmc1 and enhancement of the recombinase activity of Dmc1 by Rdh54, is demonstrated.
    Title: Functional interactions of meiotic recombination factors Rdh54 and Dmc1.
  4. Schizosaccharomyces pombe Swi5-Sfr1 complex, a conserved eukaryotic protein complex, at substoichiometric concentrations stimulates strand exchange mediated by Rhp51 (the S. pombe Rad51 homolog) and Dmc1 on long DNA substrates.
    Title: The Swi5-Sfr1 complex stimulates Rhp51/Rad51- and Dmc1-mediated DNA strand exchange in vitro.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity NAS
Non-traceable Author Statement
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent activity, acting on DNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA strand exchange activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA strand exchange activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Swi5-Sfr1 complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA recombinase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA recombinase assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA strand invasion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA strand invasion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromosome organization involved in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic gene conversion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic joint molecule formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in meiotic strand invasion involved in reciprocal meiotic recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in condensed nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
RecA family ATPase Dmc1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3382264..3383404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019590.3 → NP_594166.1  RecA family ATPase Dmc1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594166.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O42634, O42880
    Conserved Domains (3) summary
    TIGR02238
    Location:18 → 331
    recomb_DMC1; meiotic recombinase Dmc1
    cd01123
    Location:95 → 328
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam14520
    Location:18 → 73
    HHH_5; Helix-hairpin-helix domain
Nucleotide Protein
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