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fas1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543497, updated on 11-Sep-2024

Summary

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Official Symbol
fas1
Primary source
PomBase:SPAC926.09c
Locus tag
SPOM_SPAC926.09C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (3900130..3907054, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene dynein light chain Dlc2 Neighboring gene ncRNA Neighboring gene Brix domain-containing protein Rpf2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NADH kinase Pos5 Neighboring gene proteasome core particle subunit alpha 5 Pup2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cdk11-cyclinL controls the assembly of the RNA polymerase II mediator complex. Drogat J, et al. Cell Rep, 2012 Nov 29. PMID 23122962
  2. Cloning of the fatty acid synthetase beta subunit from fission yeast, coexpression with the alpha subunit, and purification of the intact multifunctional enzyme complex. Niwa H, et al. Protein Expr Purif, 1998 Aug. PMID 9693066
  3. Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis. Snaith HA, et al. J Cell Sci, 2011 Jul 1. PMID 21652630, Free PMC Article
  4. Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription. Heo DH, et al. Cell Rep, 2021 Sep 7. PMID 34496258, Free PMC Article
  5. Expanded Interactome of the Intrinsically Disordered Protein Dss1. Schenstrøm SM, et al. Cell Rep, 2018 Oct 23. PMID 30355493, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables [acyl-carrier-protein] S-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables [acyl-carrier-protein] S-malonyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables enoyl-[acyl-carrier-protein] reductase (NADH) activity ISO
Inferred from Sequence Orthology
more info
  
enables fatty acid synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fatty acyl-[ACP] hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty-acyl-CoA synthase activity NAS
Non-traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane lipid biosynthetic process IC
Inferred by Curator
more info
  
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
part_of fatty acid synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of fatty acid synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fatty acid synthase beta subunit Fas1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3900130..3907054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019791.3 → NP_594370.1  fatty acid synthase beta subunit Fas1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594370.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P78799, Q9UUG0
    Conserved Domains (6) summary
    COG0331
    Location:1678 → 2063
    FabD; Malonyl CoA-acyl carrier protein transacylase [Lipid transport and metabolism]
    COG4981
    Location:546 → 1359
    COG4981; Enoyl reductase domain of yeast-type FAS1 [Lipid transport and metabolism]
    cd03447
    Location:1552 → 1679
    FAS_MaoC; FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD).
    pfam08354
    Location:1020 → 1076
    DUF1729; Domain of unknown function (DUF1729)
    cl00509
    Location:1288 → 1414
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
    cl21457
    Location:580 → 855
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
Nucleotide Protein
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