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Mxi1 MAX interactor 1, dimerization protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 25701, updated on 10-Jul-2024

Summary

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Symbol
Mxi1provided by RGD
Full Name
MAX interactor 1, dimerization proteinprovided by RGD
Primary source
RGD:3128
See related
EnsemblRapid:ENSRNOG00000034078 AllianceGenome:RGD:3128
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MXI-WR
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to contribute to DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Used to study breast adenocarcinoma and esophageal cancer. Human ortholog(s) of this gene implicated in neurofibrosarcoma and prostate cancer. Orthologous to human MXI1 (MAX interactor 1, dimerization protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 214.1), Muscle (RPKM 205.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mxi1 in Genome Data Viewer
Location:
1q55
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (262329274..262389037)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (252323915..252383682)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (274030748..274090071)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484836 Neighboring gene uncharacterized LOC134484110 Neighboring gene uncharacterized LOC108349710 Neighboring gene survival motor neuron domain containing 1 Neighboring gene uncharacterized LOC103691375 Neighboring gene U2 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mxi1 is a potential cellular target of carcinogens and frequently mutated in experimental rat tumors and tumor cell lines. Wang DY, et al. Pathol Int, 2000 May. PMID 10849326
  2. The influence of H-2 gene products on cell-mediated and humoral immune responses. von Boehmer H, et al. Cold Spring Harb Symp Quant Biol, 1977. PMID 70302
  3. Mxi1 inhibits the proliferation of U87 glioma cells through down-regulation of cyclin B1 gene expression. Manni I, et al. Br J Cancer, 2002 Feb 1. PMID 11875718, Free PMC Article
  4. Dynamic in vivo interactions among Myc network members. Yin X, et al. Oncogene, 2001 Aug 2. PMID 11498788
  5. Mxi1 mutations in human neurofibrosarcomas. Li XJ, et al. Jpn J Cancer Res, 1999 Jul. PMID 10470286, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst formation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
max-interacting protein 1
Names
Max interacting protein 1
Max interactor 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013160.2 → NP_037292.2  max-interacting protein 1

    See identical proteins and their annotated locations for NP_037292.2

    Status: PROVISIONAL

    Source sequence(s)
    BC081824
    UniProtKB/Swiss-Prot
    O09015
    UniProtKB/TrEMBL
    K3W4V2, Q642D1
    Related
    ENSRNOP00000067990.3, ENSRNOT00000076779.4
    Conserved Domains (1) summary
    cd18930
    Location:68 → 147
    bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    262329274..262389037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231604.1 → XP_006231666.1  max-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006231666.1

    UniProtKB/TrEMBL
    A0A096MJ60, A6JHU5
    Related
    ENSRNOP00000107728.1, ENSRNOT00000150550.1
    Conserved Domains (1) summary
    smart00353
    Location:140 → 192
    HLH; helix loop helix domain

  2. XM_006231606.2 → XP_006231668.1  max-interacting protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006231668.1

    UniProtKB/Swiss-Prot
    O09015
    UniProtKB/TrEMBL
    A6JHU9
    Related
    ENSRNOP00000040770.4, ENSRNOT00000042822.6
    Conserved Domains (1) summary
    cd18930
    Location:32 → 111
    bHLHzip_MXI1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-interacting protein 1 (MXI1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O09015.1 GenPept UniProtKB/Swiss-Prot:O09015

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